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Star Scientific seeks FDA marketing approval for Ariva-BDL dissolvable tobacco lozenge

Star Scientific, Inc. announced that on Friday, February 19 the company filed an application with the Food & Drug Administration for approval to market Ariva-BDL™ as a "modified risk" tobacco product under the Family Smoking Prevention and Tobacco Control Act of 2009. This submission is the first such application to be filed with the Tobacco Products Center of the FDA, which has been established to oversee all aspects of tobacco regulation outlined in the 2009 Act.

23 Feb 2010

Merrimack Pharmaceuticals commences dosing in MM-121/Tarceva combination Phase 1/2 study for NSCLC

Merrimack Pharmaceuticals, Inc. announced today that the first patient has received an initial dose in a Phase 1/2 clinical study combining MM-121 with Tarceva® (erlotinib) in patients with non-small cell lung cancer (NSCLC). This is the first of multiple trials that Merrimack and sanofi-aventis expect to initiate in 2010 as part of a broad Phase 2 clinical development program for MM-121.

23 Feb 2010

Gilead Sciences receives FDA approval for new inhaled antibiotic in treatment of CF

The U.S. Food and Drug Administration approved an important new inhaled antibiotic called Cayston® (aztreonam for inhalation solution) today for the treatment of cystic fibrosis. The drug was made possible by significant support from the Cystic Fibrosis Foundation, including a $1 million investment by a Foundation subsidiary to help develop the therapy.

22 Feb 2010

Alnylam Pharmaceuticals initiates ALN-RSV01 Phase IIb trial in adult lung transplant patients for RSV infection

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has initiated a Phase IIb trial in adult lung transplant patients with ALN-RSV01, an RNAi therapeutic for the treatment of respiratory syncytial virus (RSV) infection. RSV infection in lung transplant patients represents an important unmet medical need; the condition is associated with significant morbidity, including the development of acute lung transplant rejection in 10% to 20% of infected patients.

22 Feb 2010

Choking among children: AAP releases new policy statement

Choking is a leading cause of injury and death among children, especially those younger than 4 years of age. The majority of choking-related incidents among children are associated with food, coins and toys. A new policy statement from the American Academy of Pediatrics (AAP), led by a doctor at Nationwide Children's Hospital and published in the February 22 online issue of Pediatrics, takes a closer look at preventing choking among children.

22 Feb 2010

Racial differences in beliefs and perceptions of lung cancer

A new survey finds that while both whites and African Americans know and think little about lung cancer, African Americans are more likely to hold beliefs and perceptions about the disease that could interfere with prevention and treatment. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the report indicates that public health messages regarding lung cancer should be targeted to all communities.

22 Feb 2010

Racial disparities in beliefs about lung cancer

A new survey has found that African-Americans are more likely than whites to hold mistaken and fatalistic beliefs about lung cancer, as well as being more reluctant to consult a doctor about possible symptoms of the disease, according to researchers from Dana-Farber Cancer Institute and their collaborators.

22 Feb 2010

Health worker training program cuts stillbirths by 30% in 6 developing countries, study says

The rate of stillbirths was cut by more than 30 percent after health workers in rural parts of six developing countries were trained "in how to help a newborn start breathing and to keep it warm and clean," according to a study published in the New England Journal of Medicine, Reuters reports. The trainees - who included midwives, nurses, traditional birth attendants and physicians - were given "hand-held pumps and masks to fill babies' lungs with air if they were not breathing at birth, clean-delivery kits to prevent infection and scales to measure their weight," the news service writes.

20 Feb 2010

Health groups call for cigarette manufacturers to pay for anti-smoking education campaigns and quit-smoking programs

Six public health groups today asked the U. S. Supreme Court to authorize a trial court to require major cigarette manufacturers to pay for a broad public education campaign against smoking, as well as programs to help smokers quit. The groups also asked that the trial court be empowered to require the tobacco companies to forfeit profits they made during decades of illegal activity.

20 Feb 2010

Aeolus Pharmaceuticals' first fiscal quarter net loss rises

Aeolus Pharmaceuticals, Inc. announced today financial results for the three months ended December 31, 2009. The Company reported a net loss of $15,276,000, or $0.33 per basic share, compared to a loss of $459,000, or $0.01 per basic share, for the three months ended December 31, 2008.

19 Feb 2010

Polyphor discovers new class of antibiotics effective against multi-drug resistant Gram-negative bacteria

Today, Polyphor Ltd published the discovery of a new class of antibiotics with a novel mode of action (Science, VOL 327, ISSUE 5968). This proprietary new class of antibiotics is effective against multi-drug resistant Gram-negative bacteria, opening up new treatment options for serious and often life-threatening infections. The most advanced drug candidate in this new class, POL7080, selectively kills the dangerous bacteria Pseudomonas aeruginosa.

19 Feb 2010

United Therapeutics announces withdrawal of Tyvaso European MAA for treatment of PAH

United Therapeutics Corporation announced today that it has withdrawn its Marketing Authorization Application (MAA) for Tyvaso (treprostinil sodium) 0.6 mg/ml nebuliser solution for the treatment of pulmonary arterial hypertension (PAH) in the European Union.

19 Feb 2010

Most genetic abnormalities shared across multiple cancers

An international team of researchers has created a genome-scale map of 26 different cancers, revealing more than 100 genomic sites where DNA from tumors is either missing or abnormally duplicated compared to normal tissues. The study, the largest of its kind, finds that most of these genetic abnormalities are not unique to one form of cancer, but are shared across multiple cancers. The work appears in the February 18 issue of the journal Nature.

19 Feb 2010

Emerging concepts from gene regulation studies in immune cells

The seventh meeting in the “Emergence and Convergence” series jointly organized by La Fondation IPSEN and Nature brings together today in San Antonio (Texas, USA) leading experts to discuss concepts emerging from gene regulation studies in immune cells that have led to insights into the initiation and maintenance of epigenetic chromatin marks necessary for proper differentiation and function of these cells in the immune system.

19 Feb 2010

Mayo Clinic's first DCD lung transplantation performed in 59-year-old Illinois man

Lung transplantation is a well-known therapy for patients with end-stage lung disease, but, as with other patients waiting for organs for transplantation, there are more recipients waiting than donors available. A potential solution for patients with end-stage lung disease is donation after cardiac death (DCD). Mayo Clinic reports its - and Minnesota's - first lung transplantation from DCD in the February issue of Mayo Clinic Proceedings.

19 Feb 2010

FDA approves 53 new cancer indications between July 2005 and end of 2007

The U.S. Food and Drug Administration's Office of Oncology Drug Products approved more than 50 new indications for the use of oncology and hematology drugs and biologics between July 2005, when the office began reviewing marketing applications, and the end of 2007, according to a new agency study.

19 Feb 2010

Research shows natural compound in marine sponges reduces cancer cell motility

Investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham, formerly Burnham Institute for Medical Research) led by Kristiina Vuori, M.D., Ph.D., have discovered that the natural compound sceptrin, which is found in marine sponges, reduces cancer cell motility (movement) and has very low toxicity.

19 Feb 2010

VARI researchers find ways to reverse resistance to sunitinib: Patients with ccRCC show positive response

Van Andel Research Institute researchers have found a way to reverse resistance to sunitinib, a treatment that is currently the first line of defense against clear cell renal cell carcinoma (ccRCC), a deadly form of kidney cancer. Most patients who show a positive response to sunitinib develop a resistance to the drug after one year of treatment.

19 Feb 2010

Six states to study sickle cell disease and thalassemias in national pilot project

Medical researchers are developing a new surveillance system to determine the number of patients diagnosed with a family of inherited blood disorders known as hemoglobinopathies, including sickle cell disease, thalassemias, and hemoglobin E disease.

19 Feb 2010

Walker's book focuses on deaths, genetic deformities and other health issues resulting from environmental pollution

Since the brain-injuring virus needs mosquitoes and pigs to spread, government officials should ban standing water in cemetery cisterns and urban drainage ditches. They should keep industrial "piggeries" away from cities and their populations.

19 Feb 2010

Lungs News and Research

Star Scientific seeks FDA marketing approval for Ariva-BDL dissolvable tobacco lozenge

Merrimack Pharmaceuticals commences dosing in MM-121/Tarceva combination Phase 1/2 study for NSCLC

Gilead Sciences receives FDA approval for new inhaled antibiotic in treatment of CF

Alnylam Pharmaceuticals initiates ALN-RSV01 Phase IIb trial in adult lung transplant patients for RSV infection

Choking among children: AAP releases new policy statement

Racial differences in beliefs and perceptions of lung cancer

Racial disparities in beliefs about lung cancer

Health worker training program cuts stillbirths by 30% in 6 developing countries, study says

Health groups call for cigarette manufacturers to pay for anti-smoking education campaigns and quit-smoking programs

Aeolus Pharmaceuticals' first fiscal quarter net loss rises

Polyphor discovers new class of antibiotics effective against multi-drug resistant Gram-negative bacteria

United Therapeutics announces withdrawal of Tyvaso European MAA for treatment of PAH

Most genetic abnormalities shared across multiple cancers

Emerging concepts from gene regulation studies in immune cells

Mayo Clinic's first DCD lung transplantation performed in 59-year-old Illinois man

FDA approves 53 new cancer indications between July 2005 and end of 2007

Research shows natural compound in marine sponges reduces cancer cell motility

VARI researchers find ways to reverse resistance to sunitinib: Patients with ccRCC show positive response

Six states to study sickle cell disease and thalassemias in national pilot project

Walker's book focuses on deaths, genetic deformities and other health issues resulting from environmental pollution

The ultimate guide to lung research tools and protocols eBook

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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