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Clinical study shows new mechanism that BCG vaccine uses to reverse advanced type 1 diabetes

Interim results from a FDA-approved clinical trial testing the generic vaccine bacillus Calmette-Guérin (BCG) to reverse advanced type 1 diabetes are being presented at the 75th Scientific Sessions of the American Diabetes Association.

12 Jun 2017

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

In an expanded, three-year clinical trial of 86 patients with colorectal and 11 other kinds of cancer that have so-called 'mismatch repair' genetic defects, scientists at Johns Hopkins Medicine and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have found that half of the patients respond to an immunotherapy drug called pembrolizumab.

9 Jun 2017

New cancer drug shows promise to treat leukemia in mouse models

Almost 6,000 new cases of acute lymphoblastic leukemia, or ALL, are expected to be diagnosed this year in the United States. The blood cancer can affect both children and adults.

9 Jun 2017

Study provides new insight into cells that rejuvenate the brain

Alzheimer's disease is a neurodegenerative disease manifested by various neuronal pathological processes and a significant decline in brain function.

9 Jun 2017

Study finds evidence that genes influence empathy

New research has found empathy may have a genetic component that also influences personality, cognition, and psychiatric conditions. Further, although not a novel finding, researchers noted women generally performed better on a test used to gauge empathy than their male counterparts.

9 Jun 2017

Delayed food introduction may increase likelihood of allergy in later childhood

Delaying the introduction of potentially allergenic foods until after a baby's first year may increase the likelihood of a food allergy later on, according to new findings from the Canadian Healthy Infant Longitudinal Development Study.

8 Jun 2017

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

It is almost axiomatic in medicine that the study of rare disorders informs the understanding of more common, widespread ailments.

8 Jun 2017

New guidelines provide clinical and physical indicators to detect dementia with Lewy bodies

New guidelines have been published on the clinical and physical indicators to help ensure patients with dementia with Lewy bodies get an accurate diagnosis and the best care possible.

8 Jun 2017

Researchers create 3D heart tissue from stem cells for drug testing

Researchers at the Institute of Bioengineering and Nanotechnology of A*STAR have engineered a three-dimensional heart tissue from human stem cells to test the safety and efficacy of new drugs on the heart.

7 Jun 2017

Two-pronged algorithm may prove to be accurate tool for predicting response to checkpoint inhibitors

The class of immunotherapies known as checkpoint inhibitors have proven to be a highly effective and advantageous treatment option for many cancer patients, but they don't work well for everyone, and oncologists have no reliable way to determine in advance which patients are likely to respond to these drugs.

7 Jun 2017

Researchers identify new class of regulatory RNAs involved in cancer pathologies

A team of researchers at the Institute of Oncology Research has identified a new class of regulatory RNAs, which are able to act as molecular switches and can contribute in controlling the genetic evolution processes that are responsible for some cancer pathologies.

7 Jun 2017

Natural sugar may trigger immune system to treat atherosclerosis, study finds

Researchers have long sought ways to harness the body's immune system to treat disease, especially cancer.

7 Jun 2017

Scientists reveal 12-hour autonomous biological clock that coordinates bodily functions

Some bodily activities, sleeping, for instance, mostly occur once every 24 hours; they follow a circadian rhythm. Other bodily functions, such as body temperature, cognitive performance and blood pressure, present an additional 12-hour cycle, but little is known about the biological basis of their rhythm.

6 Jun 2017

Study suggests promising therapeutic strategy for childhood brain tumor

A study published in Molecular Cancer Research reveals that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3K27M), which is found in up to 70 percent of childhood brain tumors called diffuse intrinsic pontine glioma (DIPG).

6 Jun 2017

Newly discovered mechanism in type 2 diabetes opens doors to clinical treatments

A newly discovered mechanism behind reduced insulin production in type 2 diabetes is now being presented.

6 Jun 2017

New findings highlight possibility of developing specific cancer drugs with fewer side effects

Scientists at Karolinska Institutet in Sweden report that cancer cells and normal cells use different 'gene switches' in order to regulate the expression of genes that control growth.

6 Jun 2017

Stowers scientists provide evidence of cross-talk between Nanog and Hox genes

Competing regulatory genes "talk" to each other to maintain balance of cell state, according to new research from the Stowers Institute for Medical Research.

6 Jun 2017

Researchers uncover protective mechanism of rotifers that may have implications for aging research

Rotifers are tough, microscopic organisms highly resistant to radiation and repeated cycles of dehydration and rehydration.

6 Jun 2017

Researchers discover connection between processes that keep the heart from repairing itself

Heart muscle is one of the least renewable tissues in the body, which is one of the reasons that heart disease is the leading cause of death for both men and women in the United States, according to the Centers for Disease Control and Prevention.

5 Jun 2017

Tiny microRNA could act as protective mechanism to reduce risk of epileptic seizures, say scientists

A tiny microRNA has been shown to play a beneficial role in protecting the brain from epileptic seizures in specially engineered transgenic mice. Scientists at the Hebrew University of Jerusalem say it could act as a protective mechanism to reduce the risk of epileptic seizures in humans.

5 Jun 2017

Genes News and Research

Clinical study shows new mechanism that BCG vaccine uses to reverse advanced type 1 diabetes

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

New cancer drug shows promise to treat leukemia in mouse models

Study provides new insight into cells that rejuvenate the brain

Study finds evidence that genes influence empathy

Delayed food introduction may increase likelihood of allergy in later childhood

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

New guidelines provide clinical and physical indicators to detect dementia with Lewy bodies

Researchers create 3D heart tissue from stem cells for drug testing

Two-pronged algorithm may prove to be accurate tool for predicting response to checkpoint inhibitors

Researchers identify new class of regulatory RNAs involved in cancer pathologies

Natural sugar may trigger immune system to treat atherosclerosis, study finds

Scientists reveal 12-hour autonomous biological clock that coordinates bodily functions

Study suggests promising therapeutic strategy for childhood brain tumor

Newly discovered mechanism in type 2 diabetes opens doors to clinical treatments

New findings highlight possibility of developing specific cancer drugs with fewer side effects

Stowers scientists provide evidence of cross-talk between Nanog and Hox genes

Researchers uncover protective mechanism of rotifers that may have implications for aging research

Researchers discover connection between processes that keep the heart from repairing itself

Tiny microRNA could act as protective mechanism to reduce risk of epileptic seizures, say scientists

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