DNA Damage News and Research

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Researchers identify biochemical switch required for nerve cells to respond to DNA damage

The finding, scheduled for advance online publication in Nature Cell Biology, illuminates a connection between proteins involved in neurodegenerative disease and in cells' response to DNA damage.

19 Jan 2009

Ground-breaking test for spem quality

Scientists have developed a ground-breaking method for testing the quality of a sperm before it is used in IVF and increase the chances of conception.

19 Jan 2009

Study shows how defective DNA repair triggers 2 neurological diseases

Scientists at St. Jude Children's Research Hospital have teased apart the biological details distinguishing two related neurological diseases-ataxia telangiectasia-like disease (ATLD) and Nijmegen breakage syndrome (NBS).

15 Jan 2009

Time of day influences response to chemotherapy

For years, research has hinted that the time of day that cancer patients receive chemotherapy can impact their chances of survival.

14 Jan 2009

Cell phone use not linked to melanoma of the eye

Mobile phone use is not associated with the risk of melanoma of the eye, researchers report in the January 13 online issue of the Journal of the National Cancer Institute.

13 Jan 2009

Variations in mismatch repair genes predict prognosis in pancreatic cancer

Variations in mismatch repair genes can help predict treatment response and prognosis in patients with pancreatic cancer, according to research from The University of Texas M. D. Anderson Cancer Center presented today in advance of the American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium.

13 Jan 2009

Virtuoso cell engineering

University of Michigan researchers have discovered that a key protein in cells plays a critical role in not one, but two processes affecting the development of cancer.

6 Jan 2009

Researchers show mechanisms that regulate DNA damage control and replication

Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair.

5 Jan 2009

Few DNA repair gene variants associated with increased cancer risk

Variants of numerous DNA repair genes initially appeared to be statistically significantly associated with cancer risk in epidemiological studies.

1 Jan 2009

Drinkers with the ADH1C gene at greater risk of colorectal cancer

Chronic drinking is a risk factor for colorectal cancer, possibly through the effects of acetaldehyde, which is created by the alcohol dehydrogenase (ADH) enzyme.

21 Dec 2008

Trial looks at new treatment for solid cancer tumors and non-Hodgkin's lymphoma

Researchers at The Cancer Institute of New Jersey (CINJ) have opened a clinical trial, which aims to evaluate a new treatment for solid cancer tumors and non-Hodgkin's lymphoma (NHL) in combination with a chemotherapy agent called cyclophosphamide.

12 Dec 2008

Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer

A genetic malfunction that causes DNA instability in people with the blood disorder Fanconi anemia may put them at high risk for squamous cell carcinomas linked to human papillomavirus (HPV), according to a study posted online ahead of print by Oncogene.

3 Dec 2008

New insights into cellular senescence

Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

3 Dec 2008

Researchers find that when cells shut down they also spew proteins into their surrounding environment

Cells shut down and stop dividing when their DNA is damaged, in a process known as cellular senescence, so as to prevent damaged DNA from leading to unregulated cell division and therefore cancer.

1 Dec 2008

Researchers provide new evidence that aging can be slowed

New evidence may explain why it is that we lose not only our youthful looks, but also our youthful pattern of gene activity with age.

26 Nov 2008

Researchers identify a potentially universal mechanism of aging

Like our current financial crisis, the aging process might also be a product excessive deregulation.

26 Nov 2008

Does hormone treatment predispose patients to breast cancer?

Breast cancer, the leading cause of death among women in France, is the most commonly occurring cancer in women.

21 Nov 2008

Researchers reveal a new aspect of tumor development

The DNA in our cells is constantly under assault from oxygen, the sun's radiation and environmental stresses.

20 Nov 2008

Bionovo to present phase 1B trial results of BZL101 in metastatic breast cancer

Bionovo, Inc. has announced the company will present results from the Phase 1B clinical trial of their lead drug candidate for advanced metastatic breast cancer, BZL101, at the Society for Integrative Oncology's Fifth International Conference in Atlanta, Georgia.

20 Nov 2008