Mouse Model News and Research

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Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model.

18 May 2022

Recombinant protein vaccine stands up to SARS-CoV-2 variants

A study by researchers in Texas describes a mouse model in which a subunit vaccine with alum-CpG adjuvant was tested for its ability to induce a broadly neutralizing antibody response against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

18 May 2022

The impact of NSAIDs on COVID-19 severity

Researchers examine potential correlations between NSAID use and COVID-19 severity.

18 May 2022

Experimental drug more effective than existing FDA-approved medications for ALS

New research on the experimental drug, NU-9, invented and developed by two Northwestern University scientists to treat ALS (amyotrophic lateral sclerosis), shows it is more effective than existing FDA-approved drugs for the disease.

17 May 2022

Mice live longer with nasal gene therapy

In a recent study published in the Proceedings of the National Academy of Sciences journal, researchers assessed the efficiency of a novel intranasal and injectable therapy in improving life expectancy.

17 May 2022

Exercise increases dopamine signaling in the mouse brain

Exercise increases dopamine signaling in the motor areas of mice, according to research recently published in JNeurosci.

16 May 2022

New mouse model shows the connection between stress, depression and cardiovascular disease risk

Results from a new mouse model may aid in understanding how depression and prolonged and severe stress increase the risk of cardiovascular disease, according to preliminary research presented at the American Heart Association's Vascular Discovery: From Genes to Medicine Scientific Sessions 2022.

13 May 2022

Maternal obesity greatly increases offspring's risk of cardiac problems in later life

Maternal obesity impairs heart health and function of the fetus according to a new study in mice. The study, published in The Journal of Physiology found that maternal obesity causes molecular changes in the heart of the fetus and alters expression of genes related to nutrient metabolism, which greatly increases offspring's risk of cardiac problems in later life.

12 May 2022

Direct influenza infection of the heart drives cardiac complications, study reveals

Researchers have shown for the first time in mice that heart problems associated with the flu are not caused by raging inflammation in the lungs, as has long been predicted.

11 May 2022

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

UNC School of Medicine Scientists have shown for the first time that postnatal gene therapy may be able to prevent or reverse many deleterious effects of a rare genetic disorder called Pitt-Hopkins syndrome.

10 May 2022

LJI researchers uncover new drug target for severe asthma, lung fibrosis

If you've ever struggled to breathe, you've had a moment of hypoxia - a lack of oxygen. Hypoxia can have long-term effects. In fact, doctors describe hypoxia as an "initial insult."

9 May 2022

Stem cell therapy prevents type 1 diabetes induced by anti-cancer drugs

Immune checkpoint inhibitors are widely used to treat a variety of cancers; however, one serious side effect is the onset of type 1 diabetes.

6 May 2022

Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

It's not often that a failed clinical trial leads to a scientific breakthrough. When patients in the UK started showing adverse side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back through the data and worked with patient samples to see what went wrong.

5 May 2022

Epigenetic abnormalities in hematopoietic cells during fetal development cause idiopathic autism

An international research group led by Professor Toru Takumi (Senior Visiting Scientist, RIKEN Center for Biosystems Dynamics Research) and Researcher Chia-wen Lin at Kobe University Graduate School of Medicine has shown that idiopathic autism is caused by epigenetic abnormalities in hematopoietic cells during fetal development, which results in immune dysregulation in the brain and gut.

2 May 2022

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

Yale researchers identify immune system culprit in severe COVID cases

Yale researchers have identified a particular immune response pathway that leads to severe illness and death in people infected by the SARS-CoV-2 virus.

28 Apr 2022

New insights could lead to better treatments for Dravet syndrome and related conditions

Children with Dravet syndrome, a severe form of epilepsy that begins in infancy, experience seizures, usually for their entire life.

27 Apr 2022

Penn scientists discover how one inflammatory disorder increases susceptibility to another

The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response.

27 Apr 2022

Genetic cause of lupus identified

An international team of researchers has identified DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments.

27 Apr 2022

Gene discovery could pave the way for new and more effective treatments for lupus

Researchers from The Australian National University have identified a gene called TLR7 that, when over-activated, is responsible for causing lupus, an autoimmune disease that can be life-threatening in severe cases.

27 Apr 2022

Mouse Model News and Research

Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

Recombinant protein vaccine stands up to SARS-CoV-2 variants

The impact of NSAIDs on COVID-19 severity

Experimental drug more effective than existing FDA-approved medications for ALS

Mice live longer with nasal gene therapy

Exercise increases dopamine signaling in the mouse brain

New mouse model shows the connection between stress, depression and cardiovascular disease risk

Maternal obesity greatly increases offspring's risk of cardiac problems in later life

Direct influenza infection of the heart drives cardiac complications, study reveals

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

LJI researchers uncover new drug target for severe asthma, lung fibrosis

Stem cell therapy prevents type 1 diabetes induced by anti-cancer drugs

Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

Epigenetic abnormalities in hematopoietic cells during fetal development cause idiopathic autism

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Yale researchers identify immune system culprit in severe COVID cases

New insights could lead to better treatments for Dravet syndrome and related conditions

Penn scientists discover how one inflammatory disorder increases susceptibility to another

Genetic cause of lupus identified

Gene discovery could pave the way for new and more effective treatments for lupus

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