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DZNE and Intravacc receive € 2.5 million EU funding to develop a prototype ALS vaccine

DZNE and Intravacc B.V., a world leading contract development and manufacturing organization (CDMO) of preventive and therapeutic vaccines, have been awarded a funding of € 2.5 million from the European Union (EIC Transition Grant) to further develop a prototype ALS vaccine, including process development, scale-up, and toxicology study.

6 Jul 2022

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

6 Jul 2022

Gene defect underlying Krabbe disease causes degeneration of neurons directly, study finds

The gene defect underlying Krabbe disease causes degeneration of neurons directly, independent of its effects on other cell types, according to a new study publishing July 5th in the open-access journal PLOS Biology by Daesung Shin of the University at Buffalo, U.S. and colleagues.

5 Jul 2022

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases.

4 Jul 2022

Scientists prove the “neuroprotective” function of p62 protein in a mouse model

Neurodegenerative diseases like Alzheimer’s and Parkinson’s are defined by pathogenic accumulation of toxic proteins in the brain.

1 Jul 2022

New signaling molecule may offer a therapeutic treatment for common form of hair loss

University of California, Irvine-led researchers have discovered that a signaling molecule called SCUBE3 potently stimulates hair growth and may offer a therapeutic treatment for androgenetic alopecia, a common form of hair loss in both women and men.

30 Jun 2022

Complex molecular dance could inform the development of future treatments for fragile X syndrome

Like many neurological diseases, there's a lot we don't understand about fragile X syndrome. But, after studying the disorder for several years, Lynne Maquat's lab knew two important things: the enzyme AKT, which plays a key role in cell growth and survival, and the quality control pathway known as NMD (nonsense-mediated mRNA decay), are both in overdrive in fragile X.

29 Jun 2022

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States described a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibody (mAb) SP1-77 that broadly neutralized its multiple variants of concern (VOCs).

28 Jun 2022

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

Lamivudine, a commonly-used antiretroviral drug for treating HIV, improves cognition in a mouse model of Down syndrome, according to the findings of a joint new study by researchers at the Centre for Genomic Regulation (CRG) and the IrsiCaixa AIDS Research Institute, a center jointly promoted by the "la Caixa" Foundation and the Department of Health of the Generalitat de Catalunya.

28 Jun 2022

Restricting timing of high fat intake improves markers of kidney and vascular health in mice

New research in a mouse model of diet-induced obesity finds that time-restricted feeding improves markers of kidney and vascular health.

27 Jun 2022

Inherited mutations in the MINAR2 gene lead to sensorineural deafness

Researchers at the John T. Macdonald Department of Human Genetics and John P. Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine have found that inherited mutations in the MINAR2 gene caused deafness in four families.

23 Jun 2022

Study links post-COVID symptoms with alterations in gut microbiota

A team of scientists has recently highlighted the significance of gut microbiota alterations induced by SARS-CoV-2 in triggering post-COVID-19 symptoms.

23 Jun 2022

Wistar scientists discover a new way to boost a person's immune response to tumors

Due to the development of resistance to chemotherapy and recurring tumors, patients with ovarian cancer often have low survival rates.

21 Jun 2022

Gut microbiome acts on the brain to control appetite

Hypothalamic GABAergic neurons recognize microbial muropeptides through the cytosolic receptor NOD2, which regulates food intake and body temperature.

19 Jun 2022

First-of-its-kind technology repairs and regenerates heart muscle cells

Researchers at the University of Houston are reporting a first-of-its-kind technology that not only repairs heart muscle cells in mice but also regenerates them following a heart attack, or myocardial infarction as its medically known.

16 Jun 2022

Researchers create first bona fide mouse model of Merkel cell carcinoma

A team of researchers at the University of Michigan Rogel Cancer Center were the first to generate a bona fide mouse model of a Merkel cell carcinoma, a rare and potentially aggressive form of skin cancer.

15 Jun 2022

Even mild respiratory COVID can affect the brain

In a recent study published in the journal Cell, researchers explored neurological symptoms and subsequent cognitive impairment experienced by survivors of mild respiratory coronavirus disease 2019 (COVID-19).

14 Jun 2022

Researchers demonstrate the feasibility of pancreatic beta-cell, target-specific CAR-Treg treatment for T1D

Researchers have successfully treated type 1 diabetes in mice using pancreatic beta-cell, target-specific, chimeric antigen-receptor (CAR) regulatory T cells (Tregs), and demonstrated the feasibility of their approach to treat the human condition according to data being presented Monday, June 13 at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

Active testosterone therapy for transgender men may worsen IVF outcomes, mouse study suggests

Active testosterone therapy for transgender men may negatively impact IVF outcomes, suggests a mouse study being presented Monday at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

Probiotic bacteria may enhance anti-cancer activities of tamoxifen to reduce ER+ breast cancer risk

Probiotic bacteria may enhance anti-cancer activities of the breast cancer drug tamoxifen and other endocrine-targeted therapies, which could help reduce the risk of estrogen receptive positive (ER+) breast cancer, suggests a new study presented Monday at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

Mouse Model News and Research

DZNE and Intravacc receive € 2.5 million EU funding to develop a prototype ALS vaccine

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

Gene defect underlying Krabbe disease causes degeneration of neurons directly, study finds

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

Scientists prove the “neuroprotective” function of p62 protein in a mouse model

New signaling molecule may offer a therapeutic treatment for common form of hair loss

Complex molecular dance could inform the development of future treatments for fragile X syndrome

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

Restricting timing of high fat intake improves markers of kidney and vascular health in mice

Inherited mutations in the MINAR2 gene lead to sensorineural deafness

Study links post-COVID symptoms with alterations in gut microbiota

Wistar scientists discover a new way to boost a person's immune response to tumors

Gut microbiome acts on the brain to control appetite

First-of-its-kind technology repairs and regenerates heart muscle cells

Researchers create first bona fide mouse model of Merkel cell carcinoma

Even mild respiratory COVID can affect the brain

Researchers demonstrate the feasibility of pancreatic beta-cell, target-specific CAR-Treg treatment for T1D

Active testosterone therapy for transgender men may worsen IVF outcomes, mouse study suggests

Probiotic bacteria may enhance anti-cancer activities of tamoxifen to reduce ER+ breast cancer risk

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