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Animal study suggests intranasal COVID vaccine delivery more efficient than intramuscular

In a recent study published in the journal PNAS, researchers demonstrated higher comparative efficacy of the intranasal (IN) route of coronavirus disease 2019 (COVID-19) vaccine administration versus intramuscular route in mice.

12 Jun 2022

Naturally-produced antibodies in mothers may enhance infants' immunity against bacterial pathogens

Researchers have known for some time that maternal breast milk provides critical nutrients for newborns, and antibodies from mothers vaccinated against a specific disease-causing bacterium or virus can be transferred via breast milk to babies.

10 Jun 2022

Creating CAR T cells without an immune brake

T cells are usually very good at eliminating diseased cells. But they seem to fail when it comes to tumor cells.

10 Jun 2022

Study reveals the benefits of using thalidomide in patients with severe arteriovenous malformations

The same properties that caused birth defects when it was given to pregnant women, the inhibition of blood vessel formation (anti-angiogenesis), have led to an interest in thalidomide's therapeutic utility in other fields.

10 Jun 2022

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

A drug used to target IDH1 mutations in select cancers also appears to inhibit the wild-type form of the enzyme, under certain conditions.

9 Jun 2022

Study sheds new light on the role of transcription factors in bone marrow microenvironments

In your home, storing books on a bookshelf, tools in a tool box, and a broom in a broom cupboard makes it easy to access these items whenever you need them.

9 Jun 2022

Targeting thalamic circuits could reverse Parkinson’s symptoms in mice

Parkinson's disease is best-known as a disorder of movement. Patients often experience tremors, loss of balance, and difficulty initiating movement. The disease also has lesser-known symptoms that are nonmotor, including depression.

8 Jun 2022

Oral administration of rapamycin increases β-amyloid buildup in Alzheimer's disease mouse model

Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have found that oral administration of rapamycin to an Alzheimer's disease mouse model causes an increase in beta (β)-amyloid protein plaques. β-amyloid buildup is a hallmark of Alzheimer's disease.

7 Jun 2022

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Researchers at UT Southwestern have developed a first-of-its-kind ultrasound-guided cancer immunotherapy platform that delivers immune-stimulating agents to cells for the development of systemic anti-tumor immunity.

7 Jun 2022

Sarbecovirus pathogenesis regulated by a multitrait locus

In a recent study posted to the bioRxiv* preprint server, the authors demonstrated that the sarbecovirus pathogenesis was regulated by a multitrait locus.

7 Jun 2022

Color-changing mouse model aids in better visualization of internal physiology

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have developed a process to change the color of a mouse's tissue in imaging to better visualize its internal physiology.

6 Jun 2022

New nanoparticles may pave the way for development of clinical sepsis therapy

Sepsis, the body's overreaction to an infection, affects more than 1.5 million people and kills at least 270,000 every year in the U.S. alone.

6 Jun 2022

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study by investigators at Weill Cornell Medicine.

2 Jun 2022

New study in mice shows alternate origins of plaques in Alzheimer’s disease

A breakdown in how brain cells rid themselves of waste precedes the buildup of debris-filled plaques known to occur in Alzheimer's disease, a new study in mice shows.

2 Jun 2022

Aerobic exercise amplifies the effects of immunotherapy to reduce pancreatic tumor growth

Aerobic exercise reprograms the immune system to reduce pancreatic tumor growth and amplify the effects of immunotherapy, a new study finds.

2 Jun 2022

The effects of accessory protein mutations and other non-spike mutations on SARS-CoV-2 pathogenesis

Researchers looked into the role played by the accessory proteins using synthetic genomics assembly technology

2 Jun 2022

New class of antibiotics found to be highly effective against drug-resistant tuberculosis

Infection by Mycobacterium tuberculosis kills 1.5 million people worldwide every year. Antibiotics to treat TB exist, but in recent years, multi-drug resistant (MDR), extensively drug-resistant (XDR) and totally drug-resistant (TDR) strains of the bacterium have developed.

31 May 2022

Mouse Model News and Research

Animal study suggests intranasal COVID vaccine delivery more efficient than intramuscular

Naturally-produced antibodies in mothers may enhance infants' immunity against bacterial pathogens

Creating CAR T cells without an immune brake

Study reveals the benefits of using thalidomide in patients with severe arteriovenous malformations

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

Study sheds new light on the role of transcription factors in bone marrow microenvironments

Targeting thalamic circuits could reverse Parkinson’s symptoms in mice

Oral administration of rapamycin increases β-amyloid buildup in Alzheimer's disease mouse model

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Sarbecovirus pathogenesis regulated by a multitrait locus

Color-changing mouse model aids in better visualization of internal physiology

New nanoparticles may pave the way for development of clinical sepsis therapy

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

New study in mice shows alternate origins of plaques in Alzheimer’s disease

Aerobic exercise amplifies the effects of immunotherapy to reduce pancreatic tumor growth

The effects of accessory protein mutations and other non-spike mutations on SARS-CoV-2 pathogenesis

New class of antibiotics found to be highly effective against drug-resistant tuberculosis

Interactive web portal details the extent of splicing events in noncoding sequences

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

New therapeutic approach harnesses the body's immune system to protect against brain damage

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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