Tyrosine News and Research

RSS

New molecular evidence of the role of the hormone prolactin in breast cancer

They have found that prolactin, a pituitary hormone that normally stimulates breast development and milk production, initiates a new “signaling pathway” that may regulate the growth and survival of breast cancer cells.

29 Sep 2007

New molecular target in blood clot formation

Researchers at the University of Illinois at Chicago College of Medicine have identified a new molecular target in blood clot formation, which seems to reduce clotting without excessive bleeding, the common side-effect of anti-clotting agents.

27 Sep 2007

Study suggests brain tumors need treatment with multiple 'targeted' drugs

Researchers at Dana-Farber Cancer Institute have shown that several, rather than just one, cell-growth switches are simultaneously overactive in many brain tumors and other solid tumors, explaining why treatment with just a single "targeted" switch-blocking drug often yields disappointing results.

13 Sep 2007

Mechanism identified that plays a critical role in multiple myeloma cell cycle and survival

Researchers at Emory University's Winship Cancer Institute are the first to discover a mechanism that plays a critical role in the multiple myeloma cell cycle and survival.

11 Sep 2007

Congestive heart failure is rare among leukemia patients who take imatinib

Congestive heart failure rarely occurs among leukemia patients who take imatinib, researchers at The University of Texas M. D. Anderson Cancer Center found after an exhaustive review of the detailed medical histories of 1,276 patients who enrolled in clinical trials for the drug.

10 Sep 2007

Genetics of imatinib resistance in acute lymphoblastic leukemia

In the September 15th issue of Genes & Development, Drs. Richard T. Williams, Willem den Besten, and Charles J. Sherr at Howard Hughes Medical Institute, St. Jude Children's Research Hospital in Memphis TN, lend new insights into how an aggressive form of acute lymphoblastic leukemia (ALL) develops, and how sensitivity to the targeted chemotherapeutic drug, imatinib, can be diminished through interactions between tumor cells and the host microenvironment.

30 Aug 2007

FDA grants orphan drug designation to TREANDA

Cephalon, Inc. announced today that the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development granted orphan drug designation for the company's investigational therapy, TREANDA (bendamustine HCl), for the treatment of chronic lymphocytic leukemia (CLL).

29 Aug 2007

New advance in search for effective treatment for human liver cancer

Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer in the July issue of Molecular Cancer Therapeutics.

12 Jul 2007

Trastuzumab and chemo improves survival in women with operable HER-2 positive breast cancer

A recent meta-analysis of five major breast cancer trials has confirmed that combination treatment with the antibody trastuzumab and chemotherapy improves survival in women with operable HER-2 positive breast cancer.

9 Jul 2007

Current status of neuroblastoma treatment and trends for the near future

Childhood cancers are fortunately rare, but among them, neuroblastoma is a special case, accounting for 7 percent of all childhood cancers, but 15 percent of childhood cancer deaths.

23 Jun 2007

Injected neural stem cells reduce Parkinson's symptoms in primates

Primates with severe Parkinson's disease were able to walk, move, and eat better, and had diminished tremors after being injected with human neural stem cells, a research team from Yale, Harvard, the University of Colorado, and the Burnham Institute report in Proceedings of the National Academy of Sciences.

14 Jun 2007

Genome detectives discover four more breast cancer genes

An international team of scientists say they have identified another four genes that increase a woman's likelihood of developing breast cancer.

28 May 2007

Scientists convert the sequence of proteins into music

UCLA molecular biologists have turned protein sequences into original compositions of classical music.

17 May 2007

Study implicates protein as a trigger of advanced prostate cancer recurrence

Scientists with the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill have for the first time implicated a growth-promoting cellular protein as one trigger of the inevitable recurrence of advanced prostate cancer in men who are undergoing drug treatment to shut down their sex hormones, or androgens.

9 May 2007

More effective therapies for individual cancers - personalized medicine

Genetic and epigenetic variations ensure that no two people are exactly alike, and the same holds true for any two cancers.

18 Apr 2007

Scientists tackle cancer with different approaches

Studies presented at the 2007 meeting of the American Association for Cancer Research show how researchers are using the new, as well as the natural, to help design and test new drugs to treat cancer.

18 Apr 2007

KCI investigators present research findings on breast cancer-causing genes

Members from the laboratory of Stephen Ethier, Ph.D., deputy center director and director of basic science for the Barbara Ann Karmanos Cancer Institute, will present research findings on breast cancer-causing genes and how they operate at the American Association of Cancer Research Annual Meeting, April 13-18, in Los Angeles, CA.

16 Apr 2007

Study suggests reason for high incidence of cancer in the prostate

Cancer occurs more frequently in the prostates of men than in any organ other than the skin. While DNA damage caused by exposure to the sun is likely the cause of many skin cancers, the cause of prostate cancer remains largely unknown.

12 Apr 2007

New regulatory mechanism for critical protein signaling domain

The study is being published in Science Express, an advanced online edition of the journal Science, on April 5. It will appear in the print version of Science later this spring.

7 Apr 2007

Inhaled corticosteroids deserve further consideration for lung cancer chemoprevention

Among a group of mostly older male veterans suffering from chronic obstructive pulmonary disease (COPD), an illness that offers a greater susceptibility to lung cancer, researchers found that regular use of high dose inhaled corticosteroids (ICS) lowered the risk of developing lung cancer.

4 Apr 2007