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Study shows new role for protein APC in suppressing colorectal cancer

A study recently published in the journal Carcinogenesis by researchers at the University of Kansas shows a new role for the protein adenomatous polyposis coli (APC) in suppressing colorectal cancer - the second-leading cause of cancer-related deaths in the U.S.

22 Aug 2014

Blood test could help gauge psychosis risk

Researchers have developed a multiplex blood assay that may aid the identification of high-risk individuals who will progress to psychosis.

21 Aug 2014

Insulin can protect cells of pancreas from acute pancreatitis

Scientists from The University of Manchester have discovered that insulin can protect the cells of the pancreas from acute pancreatitis - a disease for which there is currently no treatment.

21 Aug 2014

Study could pave way for preventing brain and cardiac ischemia induced by atherosclerosis

A recent Finnish study could pave the way for preventing brain and cardiac ischemia induced by atherosclerosis. Finnish researchers have found that the low-expression variant of fatty acid-binding protein 4 (FABP4), which is particularly common among Finns, reduces the risk of heart attack and stroke.

21 Aug 2014

OMRF receives $14.5 million grant from NIH to continue research on anthrax

The National Institutes of Health has awarded the Oklahoma Medical Research Foundation a five-year, $14.5 million grant to continue its research on anthrax and the bacteria's effects on humans.

21 Aug 2014

Scientists explore chili pepper's effect to develop new drug candidate for pain

Biting into a chili pepper causes a burning spiciness that is irresistible to some, but intolerable to others. Scientists exploring the chili pepper's effect are using their findings to develop a new drug candidate for many kinds of pain, which can be caused by inflammation or other problems.

21 Aug 2014

Scientists identify biomarker strongly associated with aggressive breast cancer

Two Northwestern University scientists have identified a biomarker strongly associated with basal-like breast cancer, a highly aggressive carcinoma that is resistant to many types of chemotherapy. The biomarker, a protein called STAT3, provides a smart target for new therapeutics designed to treat this often deadly cancer.

20 Aug 2014

Researchers shed light on the dual action of aspirin

Hugely popular non-steroidal anti-inflammation drugs like aspirin, naproxen (marketed as Aleve) and ibuprofen (Advil, Motrin) all work by inhibiting or killing an enzyme called cyclooxygenase - a key catalyst in production of hormone-like lipid compounds called prostaglandins that are linked to a variety of ailments, from headaches and arthritis to menstrual cramps and wound sepsis.

19 Aug 2014

Human gut microbiota can influence susceptibility to Campylobacter infection

The specific composition of bacterial species in a person's gut may protect against or increase susceptibility to Campylobacter, the most common cause of human bacterial intestinal inflammation, according research published this week in mBio-, the online open-access journal of the American Society for Microbiology.

19 Aug 2014

NASA study reveals how spaceflight affects immune system of crew members

There is nothing like a head cold to make us feel a little dazed. We get things like colds and the flu because of changes in our immune system. Researchers have a good idea what causes immune system changes on Earth-think stress, inadequate sleep and improper nutrition.

19 Aug 2014

Research findings call for clinical testing of relevant drugs to prevent NASH

Non-alcoholic fatty liver disease (NAFLD) is a common affliction, affecting almost 30 percent of Americans, with a significant number suffering from its most severe form, called non-alcoholic steatohepatitis or NASH, which can lead to cirrhosis and liver cancer. In recent years, NASH has become the leading cause of liver transplantation.

19 Aug 2014

Targeting club cells may help shorten duration of flu symptoms

A specialized subset of lung cells can shake flu infection, yet they remain stamped with an inflammatory gene signature that wreaks havoc in the lung, according to a study published in The Journal of Experimental Medicine.

19 Aug 2014

Innate lymphoid cells induce specific T and B cell responses during inflammation

In case of an inflammation the body releases substances that increase the immune defense. During chronic inflammation, this immune response gets out of control and can induce organ damage.

19 Aug 2014

UI scientists discover that CF mucus abnormality is present at birth

Mucus is key to keeping our lungs clean and clear of bacteria, viruses, and other foreign particles that can cause infection and inflammation. When we inhale microbes and dust, they are trapped in the mucus and then swept up and out of the lungs via a process called mucociliary transport.

16 Aug 2014

Vitamin D deficiency linked to higher surgical risk

Patients with low blood levels of vitamin D are at increased risk of death and serious complications after noncardiac surgery, suggests a study in Anesthesia & Analgesia.

16 Aug 2014

Diet reduces inflammatory markers in ‘real world’ Type 2 diabetes

Encouraging patients newly diagnosed with Type 2 diabetes to diet or to diet and increase their physical activity reduces markers of inflammation and their cardiovascular risk compared with usual care, real-world study findings show.

15 Aug 2014

Modified C. novyi-NT bacterium produces precisely targeted anti-tumor response

A modified version of the Clostridium novyi (C. novyi-NT) bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report from Johns Hopkins Kimmel Cancer Center researchers.

14 Aug 2014

Recurrence of breast cancer cut by ½ in overweight women who regularly use NSAIDs

Recurrence of hormone-related breast cancer was cut by half in overweight and obese women who regularly used aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), according to data published in Cancer Research, a journal of the American Association for Cancer Research.

14 Aug 2014

Study identifies novel gene that controls nerve conduction velocity linked with MS

A new study published in The American Journal of Pathology identifies a novel gene that controls nerve conduction velocity.

13 Aug 2014

Almonds can help reduce inflammation in people with poorly controlled diabetes

Evidence continues to mount supporting the role of almonds and other tree nuts as part of an overall dietary pattern that is beneficial for those with type 2 diabetes. Three new studies suggest a relationship between regular consumption of tree nuts, such as almonds, and improvement in various markers of health in type 2 diabetes.

12 Aug 2014