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South African SARS-CoV-2 variant neutralized by two Chinese vaccines in case study

A new study offers some reassuring findings, reporting the successful neutralization of the South African SARS-CoV-2 variant of concern (VOC) 501Y.V2 by two vaccines developed in China.

4 Feb 2021

Pfizer vaccine and Eli Lilly monoclonal antibodies successfully neutralize SARS-CoV-2 UK variant, finds study

A new study reports the underlying basis of increased transmissibility in the N501Y UK variant and provides reassuring data on the efficacy of the Pfizer vaccine and Eli Lilly monoclonal antibodies in neutralizing it.

4 Feb 2021

Monoclonal antibodies against SARS-CoV-2 spike's N-terminal prove highly protective in vivo

A new study server reports highly protective neutralizing monoclonal antibodies against the SARS-CoV-2.

4 Feb 2021

Researchers develop prototype COVID-19 vaccine using DNA vaccine platform

It is necessary to develop additional COVID-19 vaccines, as different vaccine approaches have their advantages and disadvantages and may work synergistically.

4 Feb 2021

Songbird system may provide new treatment options for children with autism

Inactivating a gene in young songbirds that are closely linked with autism spectrum disorder (ASD) prevents the birds from forming memories necessary to accurately reproduce their fathers' songs, a new study led by UT Southwestern shows.

4 Feb 2021

Study shows how SARS-CoV-2 evades immune responses

In a recurring pattern of evolution, SARS-CoV-2 evades immune responses by selectively deleting small bits of its genetic sequence, according to new research from the University of Pittsburgh School of Medicine.

4 Feb 2021

Chronic hypoxia upregulates RNA polymerase I, alters methylation on ribosomal RNAs

Hypoxia -- where a tissue is deprived of an adequate supply of oxygen -- is a feature inside solid cancer tumors that renders them highly invasive and resistant to treatment. Study of how cells adapt to this critical stressor, by altering their metabolism to survive in a low-oxygen environment, is important to better understand tumor growth and spread.

4 Feb 2021

SARS-CoV-2 has developed worrying new mutation in UK

Over the past few months, surging cases have been reported due to new fast-spreading variants. Now, Public Health England (PHE) investigates cases of COVID-19 with worrying new genetic changes. The E484K mutation, which could allow SARS-CoV-2 escape antibody protection, was seen in a small group of cases in some regions of the country.

4 Feb 2021

Predicting future mamalian hosts of SARS-CoV-2

Researchers at the Beijing Computational Science Research Center and Peking University analyzed sequences of the angiotensin-converting enzyme 2 (ACE2) proteins from 16 mammals and predicted the structures of ACE2- receptor-binding domain (RBD) complexes.

4 Feb 2021

Russia's Sputnik V COVID-19 shown to have 91.6 percent efficacy

The phase 3 human trial is the last stage of clinical evaluation, showing how effective and safe a drug or vaccine is. In this case, the Gam- Sputnik V showed a consistent strong protective effect across all participant age groups.

3 Feb 2021

Hematological findings in Amazonian patients with COVID-19

To discriminate between patients with severe and non-severe COVID-19 quickly, researchers from Peru looked for prognostic signatures in the blood samples of COVID-19 patients. Virgilio E. Failoc-Rojas et al. examined laboratory results and clinical prognosis of COVID-19 patients from a hospital in the Peruvian Amazon.

3 Feb 2021

NeuroVision Imaging receives ADDF funding to develop biomarker tests for Alzheimer's disease

NeuroVision Imaging Inc., announced today it has received an investment from the Alzheimer's Drug Discovery Foundation to support developing reliable, affordable biomarker tests for Alzheimer's disease and other forms of dementia and neurodegenerative disorders.

3 Feb 2021

Insight into role of aging in response to SARS-CoV-2 infection

Researchers at the University of California, Irvine set out to determine the differences between young people and older adults regarding their host responses against SARS-CoV-2. The team revealed that independent of disease severity, COVID-19 was linked to a significant shift in plasma inflammatory factors. The research is posted to the pre-print server medRxiv*.

3 Feb 2021

Scientists unravel the workings of a mysterious protein implicated in movement disorders

Scientists at Scripps Research have clarified the workings of a mysterious protein called Gαo, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders.

3 Feb 2021

Study gives new clues to how muscle wasting occurs on a cellular level

Muscle wasting, or the loss of muscle tissue, is a common problem for people with cancer, but the precise mechanisms have long eluded doctors and scientists. Now, a new study led by Penn State researchers gives new clues to how muscle wasting happens on a cellular level.

3 Feb 2021

Early use of therapeutic anticoagulation does not improve survival of critically ill COVID-19 patients

Although abnormal blood clotting has been identified as one of the primary causes of death from COVID-19, early treatment in an intensive care unit (ICU) with therapeutic anticoagulation (anti-clotting) for adults who are critically ill with COVID-19 does not appear to improve chances of survival, and could do more harm than good by increasing the risk for major bleeding, a multicenter research group cautions.

3 Feb 2021

Research could open the door to next-generation of cancer drugs that work better

Some of the most commonly used drugs for treating hereditary breast and ovarian cancers may not work the way we thought they did, according to new University of Colorado Boulder research.

3 Feb 2021

Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes

A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells.

3 Feb 2021

Experimental intranasal influenza vaccine produces durable immune response

An experimental single-dose, intranasal influenza vaccine was safe and produced a durable immune response when tested in a Phase 1 study published in the Journal of Clinical Investigation.

3 Feb 2021

Two studies describe processes that affect the generation of new fat cells

Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases.

3 Feb 2021

Protein C News and Research

South African SARS-CoV-2 variant neutralized by two Chinese vaccines in case study

Pfizer vaccine and Eli Lilly monoclonal antibodies successfully neutralize SARS-CoV-2 UK variant, finds study

Monoclonal antibodies against SARS-CoV-2 spike's N-terminal prove highly protective in vivo

Researchers develop prototype COVID-19 vaccine using DNA vaccine platform

Songbird system may provide new treatment options for children with autism

Study shows how SARS-CoV-2 evades immune responses

Chronic hypoxia upregulates RNA polymerase I, alters methylation on ribosomal RNAs

SARS-CoV-2 has developed worrying new mutation in UK

Predicting future mamalian hosts of SARS-CoV-2

Russia's Sputnik V COVID-19 shown to have 91.6 percent efficacy

Hematological findings in Amazonian patients with COVID-19

NeuroVision Imaging receives ADDF funding to develop biomarker tests for Alzheimer's disease

Insight into role of aging in response to SARS-CoV-2 infection

Scientists unravel the workings of a mysterious protein implicated in movement disorders

Study gives new clues to how muscle wasting occurs on a cellular level

Early use of therapeutic anticoagulation does not improve survival of critically ill COVID-19 patients

Research could open the door to next-generation of cancer drugs that work better

Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes

Experimental intranasal influenza vaccine produces durable immune response

Two studies describe processes that affect the generation of new fat cells

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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