RNA Sequencing News and Research

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Researchers establish a gene expression profile associated with cachexia in cancer patients

It is estimated that as many as 80% of advanced-stage cancer patients may develop cachexia, a potentially fatal metabolic syndrome characterized by extreme weight loss and muscle wasting, but scientists do not yet fully understand why it is more frequently associated with certain kinds of tumor than others, or why not all cancer patients develop it.

3 Mar 2020

Researchers map the cellular diversity of entire salivary gland tumors

What goes on inside and between individual cells during the very earliest stages of tumor development? Single cell sequencing technologies and a mouse model have enabled researchers to comprehensively map the cellular diversity of whole salivary gland tumors and trace the path of cancer stem cells.

20 Feb 2020

New Endothelial Cell Atlas can be used to improve treatments for many diseases

New surprising knowledge on endothelial cells in a dozen different murine tissues is now available in an open access, user-friendly, database for professionals.

20 Feb 2020

Targeted combinatorial drug treatment restores beta cell function in mice

The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes.

20 Feb 2020

Study reveals how overexposure to fluoride causes defects in tooth enamel

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel- a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises.

18 Feb 2020

Intratumoral heterogeneity linked to chemotherapy resistance in small-cell lung cancer

Small cell lung cancer accounts for 14% of all lung cancers and is often rapidly resistant to chemotherapy, resulting in poor clinical outcomes.

17 Feb 2020

New technique may yield insights on the immune response to intestinal parasite infections

A new technique may help scientists study the body's immune response to intestinal parasite infections one gut cell at a time, according to a study published today in eLife.

11 Feb 2020

Developmental shape-shifting is key to cancer's ability to spread and evade immune defenses

Just as people tend to become stuck in their ways as they grow older so too do cells. Neurons in the brain don't one day decide to become heart cells; skin cells repair wounds with skin cells rather than kidney cells.

11 Feb 2020

Heart muscle cells of zebrafish change their metabolism during heart regeneration

Researchers from the group of Jeroen Bakkers at the Hubrecht Institute have found that the muscle cells in the heart of zebrafish change their metabolism, the way in which they generate energy, during heart regeneration.

5 Feb 2020

Yale researchers take important step toward curbing the threat posed by tsetse fly

When an infected tsetse fly bites humans or other mammals to feed on their blood, microscopic parasites (African trypanosomes) in the fly's saliva are transferred. The unfortunate recipient of the bite, once infected, often faces severe health consequences, even death.

3 Feb 2020

Sperm microbiome revealed with RNA sequencing

A new study reports the first-ever detailed description of the human sperm microbiome, using newer RNA sequencing techniques that are capable of discriminating between sperm RNA and that of bacterial contamination or colonization.

2 Feb 2020

Buck study uncovers how astrocyte senescence promotes neurodegeneration

Although a link has been established between chronic inflammation and neurodegenerative diseases, there have been many open questions regarding how cellular senescence, a process whereby cells that stop dividing under stress spew out a mix of inflammatory proteins, affects these pathologies.

29 Jan 2020

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time.

29 Jan 2020

Study finds stress does whiten hair

In most cases, hair starts to gray in the thirties, and becomes pronounced in the fifties, at which time the head is typically crowned with a thatch of white, gray and perhaps some hair of the original color. A new study published January 2020 in the journal Nature, shows that this process is speeded up significantly by acute stress persisting over a period, or by severe trauma.

22 Jan 2020

'Innovative Research Award' helps CU scientists to explore BRAF inhibition resistance in brain cancer

Cancers used to be defined by where they grow in the body - lung cancer, skin cancer, brain cancer, etc. But work in recent decades has shown that cancers sharing specific genetic changes may have more in common than cancers that happen to grow in an area of the body.

21 Jan 2020

RNA Sequencing News and Research

Researchers establish a gene expression profile associated with cachexia in cancer patients

Researchers map the cellular diversity of entire salivary gland tumors

New Endothelial Cell Atlas can be used to improve treatments for many diseases

Targeted combinatorial drug treatment restores beta cell function in mice

Study reveals how overexposure to fluoride causes defects in tooth enamel

Intratumoral heterogeneity linked to chemotherapy resistance in small-cell lung cancer

New technique may yield insights on the immune response to intestinal parasite infections

Developmental shape-shifting is key to cancer's ability to spread and evade immune defenses

Heart muscle cells of zebrafish change their metabolism during heart regeneration

Yale researchers take important step toward curbing the threat posed by tsetse fly

Sperm microbiome revealed with RNA sequencing

Buck study uncovers how astrocyte senescence promotes neurodegeneration

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Study finds stress does whiten hair

'Innovative Research Award' helps CU scientists to explore BRAF inhibition resistance in brain cancer

Scientists discover how B-cells in tumor cells promote a favorable immunotherapy response

Immune system contribution to tumor heterogeneity may influence liver cancer growth

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Crab study advocates a more 'multimodal' approach to defining cell identity

New spatiomolecular map may advance understanding of the brain's decision-making area

Sequencing & Genomics: Elevating Science and Healthcare eBook

Latest eBooks

New horizons in drug discovery: High-throughput & target-to-therapy advances

A practical guide to lipid nanoparticle formulation and resizing

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology