Small Cell Lung Cancer News and Research

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Small cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung. Small cell lung cancer is an aggressive (fast-growing) cancer that can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope.

Genomes of lung cancer smokers have more mutations

Lung cancer patients with a history of smoking have 10 times more genetic mutations in their tumors than those with the disease who have never smoked, according to a new study from Washington University School of Medicine in St. Louis.

14 Sep 2012

UMass Amherst develops 'chemical nose' array to detect metastatic cancers

In the fight against cancer, knowing the enemy's exact identity is crucial for diagnosis and treatment, especially in metastatic cancers, those that spread between organs and tissues. Now chemists led by Vincent Rotello at the University of Massachusetts Amherst have developed a rapid, sensitive way to detect microscopic levels of many different metastatic cell types in living tissue. Findings appear in the current issue of the journal ACS Nano.

14 Sep 2012

Gefitinib shows promise in Chinese lung cancer patients

Gefitinib improves progression-free survival, overall response, and health-related quality of life over carboplatin/paclitaxel for first-line advanced non-small-cell lung cancer treatment, a study indicates.

13 Sep 2012

Platinum tissue concentrations predict NSCLC treatment response

Reduced tissue platinum accumulation might explain why some patients with non-small-cell lung cancer fail to respond to platinum-based chemotherapy, research shows.

13 Sep 2012

Crizotinib may be effective treatment option for NSCLC subtype

Phase I trial results show that the chemotherapy drug crizotinib may be fast-acting and produce long-lasting treatment responses in patients with anaplastic lymphoma receptor tyrosine kinase-positive non-small-cell lung cancer.

13 Sep 2012

Addition of sorafenib to chemotherapy does not prolong survival

The addition of sorafenib to gemcitabine/cisplatin fails to provide any additional benefit in chemotherapy-naïve patients with nonsquamous non-small-cell lung cancer, research shows.

13 Sep 2012

FDG–PET/CT improves staging and modifies radiotherapy management

The addition of FDG–positron emission tomography/computed tomography revised radiotherapy decision-making and enhanced tumor staging capabilities in patients with non-small-cell lung cancer, research shows.

13 Sep 2012

Hispanics/Latinos with non-small cell lung cancer have higher overall survival rates

Analysis of non-small cell lung cancer (NSCLC) patient records in the California Cancer Registry (CCR) database during the 20-year period of 1988-2008 indicates that Hispanics/Latinos with NSCLC have a higher overall survival compared to non-Hispanic white patients, according to research presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology.

7 Sep 2012

Adding bavituximab to docetaxel doubles overall survival in late-stage NS-NSCLC patients

Adding the monoclonal antibody bavituximab to docetaxel chemotherapy doubles overall response rate and improves progression-free survival and overall survival in late-stage non-squamous, non-small cell lung cancer (NS-NSCLC) patients who have already received one prior chemotherapy regimen, according to research presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology.

7 Sep 2012

Married patients with locally advanced lung cancer likely to survive longer after treatment

Married patients with locally advanced lung cancer are likely to survive longer after treatment than patients who are single, according to a study by researchers at the University of Maryland Marlene and Stewart Greenebaum Cancer Center in Baltimore.

7 Sep 2012

PCI after lung cancer treatment reduces risk of brain metastases in stage III NSCLC patients

Stage III non-small cell lung cancer (NSCLC) patients treated with surgery and/or radiation therapy have a significantly reduced risk of developing brain metastases if they also receive prophylactic cranial irradiation (PCI); however, this study did not show an improvement in overall survival with PCI, according to research presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology.

7 Sep 2012

Crizotinib effective in shrinking tumors in patients with ALK positive non-small cell lung cancer

Crizotinib is effective in shrinking tumors in patients with anaplastic lymphoma receptor tyrosine kinase (ALK) positive non-small cell lung cancer, a cancer commonly found in people who never smoked, and should be the standard of care for advanced stages of this disease, according to research presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology.

7 Sep 2012

Race, marital status can impact survival rates of patients with Stage III non-small cell lung cancer

A study of survival data for Stage III, non-small cell lung cancer (NSCLC) patients at the University of Maryland's Greenebaum Cancer Center in Baltimore indicates that marital status and race can significantly impact patient survival rates, according to research presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology.

7 Sep 2012

Study finds PARP1 and EZH2 as potential therapeutic targets for small cell lung cancer

Newly discovered molecular differences between small cell lung cancer and nonsmall cell lung cancer have revealed PARP1 and EZH2 as potential therapeutic targets for patients with small cell lung cancer, according to the results of a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

7 Sep 2012

Small Cell Lung Cancer News and Research

Genomes of lung cancer smokers have more mutations

UMass Amherst develops 'chemical nose' array to detect metastatic cancers

Gefitinib shows promise in Chinese lung cancer patients

Platinum tissue concentrations predict NSCLC treatment response

Crizotinib may be effective treatment option for NSCLC subtype

Addition of sorafenib to chemotherapy does not prolong survival

FDG–PET/CT improves staging and modifies radiotherapy management

Hispanics/Latinos with non-small cell lung cancer have higher overall survival rates

Adding bavituximab to docetaxel doubles overall survival in late-stage NS-NSCLC patients

Married patients with locally advanced lung cancer likely to survive longer after treatment

PCI after lung cancer treatment reduces risk of brain metastases in stage III NSCLC patients

Crizotinib effective in shrinking tumors in patients with ALK positive non-small cell lung cancer

Race, marital status can impact survival rates of patients with Stage III non-small cell lung cancer

Study finds PARP1 and EZH2 as potential therapeutic targets for small cell lung cancer

Scientists complete comprehensive map of genetic mutations linked to small cell lung cancers

More women and non-smokers being diagnosed with non-small cell lung cancer

Results from Biodesix VeriStrat phase II advanced lung cancer trials

ARIAD initiates multi-center ponatinib Phase 1/2 clinical trial for CML in Japan

VEGF inhibitor fails to improve nonsquamous NSCLC overall survival

Increases in NSCLC survival 'an artefact of PET assessment'

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