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ERA4TB to transform the development of new therapies for tuberculosis

With a team of more than thirty public and private organisations and a budget over 200 million euro, ERA4TB aims to radically transform the way in which new therapies are developed for the treatment of tuberculosis.

30 Jan 2020

Novel inhibitor to fight metastatic prostate cancer shows promise

When prostate cancer spreads it is often a deadly disease, but now a Stony Brook University-led research team believes a new approach that inhibits a specific fatty acid binding protein (FABP) may be the key to halting disease progression.

30 Jan 2020

Study: 25% of pathogenic bacteria can spread antibiotic resistance directly to peers

Biomedical engineers at Duke University have demonstrated that at least 25 percent of antibiotic-resistant pathogenic bacteria found in clinical settings are capable of spreading their resistance directly to other bacteria.

29 Jan 2020

Researchers identify potential target in the fight against MERS

First identified in 2012, the MERS-coronavirus is capable of causing severe and often fatal pneumonia. There are no effective treatments for MERS.

29 Jan 2020

Research reveals key molecular target for colorectal cancer therapy

Serine racemase is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate.

29 Jan 2020

Buck study uncovers how astrocyte senescence promotes neurodegeneration

Although a link has been established between chronic inflammation and neurodegenerative diseases, there have been many open questions regarding how cellular senescence, a process whereby cells that stop dividing under stress spew out a mix of inflammatory proteins, affects these pathologies.

29 Jan 2020

UB team receives $2 million NIH grant for enzyme research

In the human body, proteins called enzymes help speed up chemical reactions that are vital for life.

29 Jan 2020

Research project moves one step closer to personalized treatment of rheumatic diseases

When a patient is diagnosed with rheumatoid arthritis, psoriatic arthritis or spondyloarthritis, prescribing the correct type of medicine is a case of trial and error.

29 Jan 2020

Bandages sense infections, change color, treat infection

In what reads like science fiction, a new study published in the journal ACS Central Science reports the development of bandages that detect the presence of bacteria in wounds and change color, depending on whether they are drug-sensitive or drug-resistant. This is an important step in helping patients recover better.

29 Jan 2020

New strategy using organoids to study childhood brain tumors

A new study reports the creation of in vitro models of brain tumors in children using organoids derived from stem cells, which will help to screen new drugs for efficacy and thus improve the rate of drug development. The study, titled 'Modeling medulloblastoma in vivo and with human cerebellar organoids,' is published in the journal Nature Communications.

29 Jan 2020

Nanoparticle Trojan horse approach to clearing atherosclerotic plaques

Researchers from Michigan State University and Stanford University have designed special nanoparticles which could break down an atherosclerotic plaque from within. This could prevent heart attacks say researchers. The study titled, “Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis,” was published in the latest issue of the journal Nature Nanotechnology.

29 Jan 2020

Living longer AND living healthy

American Heart Association (AHA) President Robert A. Harrington says that the life expectancy has gone up in recent years. Still, he points out, improved life expectancy doesn’t translate to improved health in all cases. According to him, “Not all those years are healthy ones as the effects of chronic illnesses are increasingly impacting the quality of life of people at a much younger age than in the past.”

29 Jan 2020

Robotic search for drugs that block sperm motility

The hunt for the first male contraceptive pill is on, and scientists at Dundee University may have the needed tool to find it – a robotic screening system.

29 Jan 2020

Pre-existing anticancer drug could help treat common form of heart failure

When it comes to finding new treatments for disease, reinventing the wheel is not always necessary - drugs already in use for other conditions may do the job.

29 Jan 2020

Researchers identify determinant protein for metastasis in alveolar rhabdomyosarcoma

Rhabdomyosarcoma is the most common childhood cancer in the soft tissues, and it is mainly originated in the muscles.

29 Jan 2020

One-quarter of hospitalized children are prescribed antibiotics incorrectly

The overuse of antibiotics poses an increasing threat to children who develop -- or already have -- drug-resistant infections that are difficult or impossible to treat, and can cause extended hospitalization, disability and even death.

29 Jan 2020

New therapeutic strategy to fight against advanced melanoma

Scientists from the Centenary Institute have developed a new therapeutic strategy that could potentially help the fight against advanced-stage melanoma.

29 Jan 2020

Researchers develop new strategy to study childhood brain tumors

Researchers are at work to find effective treatments to help young patients with brain tumors. Hundreds of brain organoids have been developed in the laboratories of the University of Trento to understand the genetic mechanisms responsible for these hard to treat diseases.

29 Jan 2020

Study advances the understanding of capillary regression

Many diseases arise from abnormalities in our capillaries, tiny exquisitely branching blood vessel networks that play a critical role in tissue health.

29 Jan 2020

When aid-in-dying is legal, but the medicine is out of reach

The call came the last week of September, when Neil Mahoney could still stagger from his bed to the porch of his mobile home to let out his boisterous yellow Lab, Ryder.

29 Jan 2020