B Cell News and Research

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Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

A new paper deals with the identification of an antiviral compound that could help in developing additional drugs to help fight COVID-19.

30 Nov 2021

New method helps correct genetic alterations in the cultured patient cells rapidly

Researchers in the University of Helsinki and University Hospital Helsinki have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells.

30 Nov 2021

Study uncovers new mechanism to explain how obesity jeopardizes the functions of skeletal muscle

A decline in metabolism and endurance of skeletal muscle is commonly observed in obese patients, but the underlying mechanism is not well-understood.

30 Nov 2021

SARS-CoV-2 Delta spike increases viral virulence and inflammatory cytokine production

In a new study published on the bioRxiv* preprint server, scientists investigated several virological features of the Delta spike protein.

29 Nov 2021

Study on molnupiravir precursor NHC antiviral activity against SARS-CoV-2 variants of concern

In a new study, published on the bioRxiv* preprint server, scientists aimed to determine the reaction of the molnupiravir parent drug (NHC) to different SARS-CoV-2 Variants of Concern (VoCs). They also sought to establish the therapeutic window in a human lung cell model.

29 Nov 2021

Cytomegalovirus herpesvirus can accelerate the decline of the immune system, study finds

A research team at the University of Córdoba is studying the alterations that occur in the immune system's T lymphocytes with respect to age and in relation to the cytomegalovirus herpesvirus.

29 Nov 2021

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

On 22 May 2019, scientists from Queen's University boarded a modified Falcon 20 aircraft at Ottawa airport. Scheduled was a 'vomit comet' flight, where the plane repeatedly climbs to 8km in a steep parabola, alternating with a descent in freefall.

29 Nov 2021

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

The proteins that belong to the HAT family are essential for life as they transport amino acids across the cell membrane. Although the members of this family are practically identical, some transport certain amino acids and not others.

29 Nov 2021

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Scientists at the University of North Carolina at Chapel Hill School of Medicine and colleagues have demonstrated that rare variants in the ANK2 gene, consistently found in individuals with autism spectrum disorder (ASD), can alter architecture and organization of neurons, potentially contributing to autism and neurodevelopmental comorbidities.

29 Nov 2021

Biologists discover how a protein in our body works

It's an old needlework trick, and a protein in our body knows it: Instead of threading yarn into the eye from the end, it can be easier to pass a loop through it.

29 Nov 2021

SPORE-funded Kidney Cancer Program at UT Southwestern reports wide array of tumor models to date

Funded by a Specialized Program of Research Excellence award from the National Cancer Institute (NCI), the Kidney Cancer Program at UT Southwestern's Harold C. Simmons Comprehensive Cancer Center reports the largest and most diverse catalog of kidney cancer tumor models to date.

29 Nov 2021

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Researchers study human single nucleotide variants (SNVs) using machine learning to identify amino acid changes that alter kinase-bound sequence motifs.

29 Nov 2021

Simple change can maximize a single cell's production of extracellular vesicles

A simple change in the way donor cells are processed can maximize a single cell's production of extracellular vesicles, which are small nanoparticles naturally secreted by cells, according to new research from researchers at the University of Illinois Chicago.

29 Nov 2021

SARS-CoV-2 can directly invade human kidney cells, research shows

Up to 25% of patients' COVID-19 cases involve acute kidney injury—the kidneys' equivalent of a heart attack.

29 Nov 2021

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Researchers found that virus-like particles produced by co-expression of SARS-CoV-2 S, membrane, envelope, and nucleocapsid proteins contain S glycoproteins, which are modified by complex carbohydrates.

29 Nov 2021

NYU Langone opens new state-of-the-art center to treat patients with blood cancers

NYU Langone Health's Laura and Isaac Perlmutter Cancer Center opened a new state-of-the-art center to treat people with blood cancers, including leukemia, lymphoma, and multiple myeloma.

29 Nov 2021

Extended host range for SARS-CoV-2 variants of concern

Researchers used viral pseudotyping to examine whether variants of concern had different host ACE2 receptor usage patterns.

29 Nov 2021

Tomosyn protein's key contribution to heterogeneity of neurons revealed

The versatility of the nervous system comes from not only the diversity of ways in which neurons communicate in circuits, but also their "plasticity," or ability to change those connections when new information has to be remembered, when their circuit partners change, or other conditions emerge.

29 Nov 2021

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Malaria is one of the most dangerous infectious diseases. The causative pathogens are microorganisms of the genus Plasmodium.

29 Nov 2021

Researchers shed light on an important stage of early human embryogenesis for the first time

Scientists have shed light on an important stage of early embryonic development that has never been fully mapped out in humans before.

29 Nov 2021

B Cell News and Research

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

New method helps correct genetic alterations in the cultured patient cells rapidly

Study uncovers new mechanism to explain how obesity jeopardizes the functions of skeletal muscle

SARS-CoV-2 Delta spike increases viral virulence and inflammatory cytokine production

Study on molnupiravir precursor NHC antiviral activity against SARS-CoV-2 variants of concern

Cytomegalovirus herpesvirus can accelerate the decline of the immune system, study finds

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Biologists discover how a protein in our body works

SPORE-funded Kidney Cancer Program at UT Southwestern reports wide array of tumor models to date

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Simple change can maximize a single cell's production of extracellular vesicles

SARS-CoV-2 can directly invade human kidney cells, research shows

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

NYU Langone opens new state-of-the-art center to treat patients with blood cancers

Extended host range for SARS-CoV-2 variants of concern

Tomosyn protein's key contribution to heterogeneity of neurons revealed

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Researchers shed light on an important stage of early human embryogenesis for the first time

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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