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Researchers observe fast and slow molecular pathways that support memory function

A sustained state of vigilance will generate a different type of memory than a momentary startle, and these differences are linked to distinct signaling molecules in the brains of mice.

24 Jan 2020

New drug combination destroys bacterial infection that can be fatal to cystic fibrosis patients

A new treatment developed by researchers at Aston University and Birmingham Children's Hospital has been found to completely kill a bacterial infection that can be deadly to cystic fibrosis patients.

24 Jan 2020

Scientists visualize diabetes-related proteins at high resolution

Scientists have examined a key receptor for the first time at high resolution - broadening understanding of how it might function, and opening the door to future improvements in treating conditions such as type 2 diabetes.

24 Jan 2020

NIAID officials describe steps to control coronavirus that recently originated in China

The new cluster of viral pneumonia cases originating in Wuhan, China, marks the third time in 20 years that a member of the large family of coronaviruses (CoVs) has jumped from animals to humans and sparked an outbreak.

24 Jan 2020

Scientists discover why the cells need acidic lysosomes

Just like the body contains lungs, liver, and lymph nodes, so does each of the body's cells contain tiny specialized organs. Perhaps most peculiar among them are lysosomes--bubble-like sacks that act as part recycling bin, part stomach.

23 Jan 2020

Diabetes-related proteins seen in high-res for the first time

A team of researchers have reported, in an exciting study published in the journal Nature Communications, that they were able to examine an important receptor at high definition for the first time. This detailed visualization has helped them greatly to understand its mechanism of functioning. This could help develop better ways to treat Type 2 diabetes mellitus as well as other conditions.

23 Jan 2020

Researchers identify liver fibrosis ‘off switch’ in mice

Chronic alcohol abuse and hepatitis can injure the liver, often leading to a buildup of collagen and scar tissue.

23 Jan 2020

Halting metastasis by preventing cancer cells from using fat

Healthy cells normally undergo cell division, but when a genetic mutation causes uncontrolled cell growth, they form a tumor. Cancer is one of the leading causes of death worldwide, and most deaths happen when cancer cells start to metastasize or travel from the mother tumor to other parts of the body.

23 Jan 2020

Scientists discover small molecule that may slow or stop Parkinson's progression

A collaboration between scientists at Rutgers University and The Scripps Research Institute led to the discovery of a small molecule that may slow down or stop the progression of Parkinson's disease.

23 Jan 2020

Landmark study identifies 102 genes associated with autism risk

In the largest genetic sequencing study of autism spectrum disorder (ASD) to date, researchers have identified 102 genes associated with risk for autism. The study also shows significant progress towards teasing apart the genes associated with ASD from those associated with intellectual disability and developmental delay, conditions which often overlap.

23 Jan 2020

Researchers identify novel cellular entry factor for AAV vector types

Researchers led by a team at Massachusetts Eye and Ear have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types--the most commonly used viral vectors for in vivo gene therapy. AAVs are vectors-or vehicles--that are created from a virus that is made harmless by molecular engineering, and have shown promise transporting genetic therapy treatments to affected tissues.

23 Jan 2020

Researchers grow venom-producing snake organoids in the lab

Researchers from the group of Hans Clevers at the Hubrecht Institute, in an international collaboration, have developed a method to grow snake venom gland cells as organoids.

23 Jan 2020

Treatment for low back pain in older adults does not match guidelines

Many Medicare patients with new episodes of low back pain receive care inconsistent with current guidelines - including high use of opioids and advanced imaging tests, reports a study in the February issue of Medical Care.

23 Jan 2020

Researchers solve long-standing mystery linked to contraction of heart cells

We've all felt the effects of an adrenaline rush. Faced with danger, real or perceived, the heart beats faster, breathing quickens and muscles tighten as the body prepares to fight a threat or flee from it.

23 Jan 2020

Reelin can reverse the main pathological processes associated with Alzheimer's, other tauopathies

Promoting the signaling pathway of reelin -an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance the main cognitive, biochemical and behavioral alterations seen in Alzheimer's and other pathologies associated with Tau protein, as shown in a new study with animal models -published in the journal Progress in Neurobiology.

23 Jan 2020

Scientists discover new drug target for prostate cancer in the non-coding genome

Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.

23 Jan 2020

Synthego adopts GMP standards for producing sgRNA

Synthego has adopted Good Manufacturing Practice standards for producing customized GMP-grade synthetic guide RNA at its facilities, an initiative the company said will benefit its academic and industry customers as they develop advanced cell and gene therapies.

From Synthego Corporation 23 Jan 2020

Nicoya raises $10 million in series a funding to make drug discovery digital

Nicoya, a leading provider of advanced analytical instruments for the biotechnology and pharmaceutical industries, announced today that it has raised $10 million in Series A financing.

From Nicoya Lifesciences 23 Jan 2020

Controlled-release opioids may lead to endocarditis in injection drug users

A new study from ICES, Lawson Health Research Institute and Western University suggests that injection drug users prescribed controlled-release hydromorphone are three times more likely to develop endocarditis, a serious bacterial heart infection, when compared to those prescribed other opioids.

22 Jan 2020

GW expands clinical trial of neoadjuvant immunotherapy for high-risk cutaneous squamous cell carcinoma

The Cutaneous Oncology Program at the George Washington University (GW) Cancer Center was selected as the first global site for a clinical trial for patients with high-risk cutaneous squamous cell carcinoma.

22 Jan 2020