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Modeling study sheds light on SARS-CoV-2 genome packaging

Researchers at the University of North Carolina at Chapel Hill have conducted a study exploring how the spatial patterning of certain genomic RNA regions in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes compaction, packaging, and cyclization of the viral genome.

10 Jan 2021

Gene therapy can effectively treat mice with tuberous sclerosis complex, shows study

Patients with tuberous sclerosis complex, a genetic disorder characterized by the growth of noncancerous tumors in multiple organs of the body, have limited treatment options.

8 Jan 2021

Researchers unravel the process that makes viruses infectious

Researchers have for the first time identified the way viruses like the poliovirus and the common cold virus 'package up' their genetic code, allowing them to infect cells.

8 Jan 2021

Single-dose nanoparticle vaccine for SARS-CoV-2

Before the pandemic, the lab of Stanford University biochemist Peter S. Kim focused on developing vaccines for HIV, Ebola and pandemic influenza.

8 Jan 2021

Biomarkers can predict how genetically identical cells behave differently under stress

A set of biomarkers not traditionally associated with cell fate can accurately predict how genetically identical cells behave differently under stress, according to a UT Southwestern study.

8 Jan 2021

Researchers create first usable computational model of entire SARS-COV-2 virus

Researchers at the University of Chicago have created the first usable computational model of the entire virus responsible for COVID-19 - and they are making this model widely available to help advance research during the pandemic.

8 Jan 2021

New approach to tame botulinum toxin for drug delivery

While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins produced by Clostridium botulinum -- the most potent toxins known.

8 Jan 2021

Nuclear DICER complex disrupts cytoplasmic microRNAome in glioblastoma cancer cells

Like Peter Pan, some cells never grow up. In cancer, undifferentiated stem cells may help tumors such as glioblastoma become more aggressive than other forms of the disease.

8 Jan 2021

Single-dose nanoparticle COVID-19 vaccine elicits virus-neutralizing antibody response in mice

Across the world, health care workers and high-risk groups are beginning to receive COVID-19 vaccines, offering hope for a return to normalcy amidst the pandemic.

8 Jan 2021

UCSF researchers discover a new way to control immune system's 'natural killer' cells

UC San Francisco scientists have discovered a new way to control the immune system's "natural killer" (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection.

8 Jan 2021

Advanced nanomaterial-based biosensing platform rapidly detects COVID-19 antibodies

Researchers at Carnegie Mellon University report findings on an advanced nanomaterial-based biosensing platform that detects, within seconds, antibodies specific to SARS-CoV-2, the virus responsible for the COVID-19 pandemic.

8 Jan 2021

How do SARS-CoV-2 antibodies change over time in recovered patients?

Researchers studied convalescent plasma from recovered coronavirus disease 2019 (COVID-19) patients, with samples collected up to 34 weeks after recovery. They found IgG antibodies gradually declined with a median half-life of about 60 days.

8 Jan 2021

Bruker and Evosep announce major progress in unbiased, quantitative true single-cell proteomics

Bruker Corporation and Evosep today announced major progress in high-sensitivity, quantitative true single-cell proteomics, using a modified timsTOF Pro mass spectrometer connected to an Evosep One low-flow chromatography system.

From Bruker Daltonics 8 Jan 2021

Scientists decipher the structure of protein found in parasites that cause neglected tropical diseases

Brazilian researchers have managed to decipher the structure of a protein found in parasites that cause neglected tropical diseases, paving the way to the development of novel medications.

8 Jan 2021

Study: Initial COVID-19 severity is not linked to later poor respiratory problems

A new study published online in the Annals of the American Thoracic Society examines the recovery of lung function and overall wellness in individuals who had varying degrees of COVID-19 severity.

8 Jan 2021

Study: TTR protein plays a protective role in Alzheimer's disease

A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer's disease, a new study led by a UT Southwestern researcher shows.

8 Jan 2021

Gut and oral microbiomes predict COVID-19 severity

One question that continues to remain unanswered during the ongoing coronavirus disease 2019 (COVID-19) pandemic has been why is there a distinctive hit-and-miss pattern when it comes to severe disease? An interesting new study that appears on the medRxiv* preprint server pinpoints one highly relevant risk factor: the state of the oral and gut microbiomes.

7 Jan 2021

High-affinity SARS-CoV-2 RBD drives mutation spread, forms basis of new COVID-19 inhibitor

Now, an intriguing recent study appeared on the bioRxiv * preprint server describes the use of in vitro evolution to elicit affinity maturation of the viral receptor-binding domain (RBD) of the spike protein to bind the host cell angiotensin-converting enzyme 2 (ACE2) with greater affinity.

7 Jan 2021

Glycylation essential to keep sperm swimming in a straight line, shows study

One essential component of each eukaryotic cell is the cytoskeleton. Microtubules, tiny tubes consisting of a protein called tubulin, are part of this skeleton of cells.

7 Jan 2021

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer.

7 Jan 2021

Protein C News and Research

Modeling study sheds light on SARS-CoV-2 genome packaging

Gene therapy can effectively treat mice with tuberous sclerosis complex, shows study

Researchers unravel the process that makes viruses infectious

Single-dose nanoparticle vaccine for SARS-CoV-2

Biomarkers can predict how genetically identical cells behave differently under stress

Researchers create first usable computational model of entire SARS-COV-2 virus

New approach to tame botulinum toxin for drug delivery

Nuclear DICER complex disrupts cytoplasmic microRNAome in glioblastoma cancer cells

Single-dose nanoparticle COVID-19 vaccine elicits virus-neutralizing antibody response in mice

UCSF researchers discover a new way to control immune system's 'natural killer' cells

Advanced nanomaterial-based biosensing platform rapidly detects COVID-19 antibodies

How do SARS-CoV-2 antibodies change over time in recovered patients?

Bruker and Evosep announce major progress in unbiased, quantitative true single-cell proteomics

Scientists decipher the structure of protein found in parasites that cause neglected tropical diseases

Study: Initial COVID-19 severity is not linked to later poor respiratory problems

Study: TTR protein plays a protective role in Alzheimer's disease

Gut and oral microbiomes predict COVID-19 severity

High-affinity SARS-CoV-2 RBD drives mutation spread, forms basis of new COVID-19 inhibitor

Glycylation essential to keep sperm swimming in a straight line, shows study

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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