Protein C News and Research

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Sugar-binding protein could promote inflammation and worsen sepsis

A sugar-binding protein could fuel terrible inflammation and worsen sepsis, a disease that kills more than 270,000 people every year in the US alone, reports a team of researchers led by UConn Health in the 4 January issue of Nature Immunology.

4 Jan 2021

Epigenetic modulators have a rapid antidepressant-like effect, study shows

Treatment of depression faces two main challenges. The first is that almost 50% of patients do not respond well to existing antidepressants.

4 Jan 2021

Inflammation marker linked to increased fatigue in prostate cancer patients treated with ADT

Prostate cancer is one of the most common cancers among men in the U.S. For many patients, hormone therapy is a treatment option.

4 Jan 2021

Biologist receives NIH grant to build software tools to predict cancer drug efficacy

One of the most promising areas of human cancer research is the study of signal transduction, or cell signaling.

4 Jan 2021

Higher hemoglobin threshold does not improve outcomes in preterm infants

Very low birthweight infants are at a high risk for anemia and often need blood transfusions to survive. Some doctors use a higher level and some use a lower level of red blood cells to order a transfusion.

4 Jan 2021

Study: Frailty is a risk factor among women waiting for liver transplants

Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver.

4 Jan 2021

Phase 3 results show investigational vaccine is effective in preventing severe COVID-19

The investigational vaccine known as mRNA-1273 was 94.1% efficacious in preventing symptomatic coronavirus disease 2019 (COVID-19), according to preliminary results from a Phase 3 clinical trial reported in the New England Journal of Medicine.

3 Jan 2021

Protein employs twist‐and‐squeeze mechanism to expel chemotherapeutics from cancer cells

In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University's Institute for Integrated Cell-Material Sciences, discovered that a protein called ABCB1 could transport multiple chemotherapeutics out of some cancer cells, making them resistant to treatment. How it did this has remained a mystery for the past 35 years.

29 Dec 2020

Study offers explanation for silent hypoxemia in COVID-19 patients

One of the physiopathological characteristics of COVID-19 that has most baffled the scientific and medical community is what is known as "silent hypoxemia" or "happy hypoxia".

29 Dec 2020

Large transporter protein dysfunction associated with schizophrenia

Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens.

29 Dec 2020

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer's aggressiveness.

28 Dec 2020

Phase 3 trial of Novavax COVID-19 vaccine candidate begins enrolling volunteers

The Phase 3 trial of another investigational coronavirus disease 2019 (COVID-19) vaccine has begun enrolling adult volunteers.

28 Dec 2020

Researchers develop new drug discovery method targeting membrane proteins on live cells

A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.

28 Dec 2020

Surgery may increase length of survival for metastatic breast cancer patients

Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to Penn State College of Medicine and Penn State Cancer Institute researchers.

28 Dec 2020

Researchers develop new system for direct detection of SARS-CoV-2 in aerosols

Researchers from the Polytechnic University of Valencia, in collaboration with specialists from the University of Valencia (UV), have come up with a new system based on a high-sensitivity mass biosensor that continuously monitors signals for the direct detection of SARS-CoV-2 in environmental aerosols.

28 Dec 2020

Protein encourages similar developing cells to clump together

Tohoku University scientists have, for the first time, provided experimental evidence that cell stickiness helps them stay sorted within correct compartments during development.

24 Dec 2020

Severity of COVID-19 correlates with the ratio of antibodies targeting crucial viral protein

COVID-19 antibodies preferentially target a different part of the virus in mild cases of COVID-19 than they do in severe cases, and wane significantly within several months of infection, according to a new study by researchers at Stanford Medicine.

24 Dec 2020

SARS-CoV-2 spike-antibody binding strength and hydrogen bond numbers are temperature dependent, study finds

A new preprint on the bioRxiv* server describes the interactions between the binding spike protein of the SARS-CoV-2 virus with the antibodies. Earlier studies have addressed the similarity in the 3D structures of the spike protein in the two SARS viruses as seen on cryo-EM.

24 Dec 2020

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

In a new study, released on the bioRxiv* preprint server, a team of researchers explores the antiviral potential of red blood cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19.

24 Dec 2020

Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

A new study preprint on the bioRxiv* server demonstrates the ability of a fatty acid synthase inhibitor to improve the survival of mice infected with murine hepatitis virus. In so doing, it adds to the sum of knowledge about the relationship of SARS-CoV-2 with cholesterol metabolism in the host cell.

24 Dec 2020

Protein C News and Research

Sugar-binding protein could promote inflammation and worsen sepsis

Epigenetic modulators have a rapid antidepressant-like effect, study shows

Inflammation marker linked to increased fatigue in prostate cancer patients treated with ADT

Biologist receives NIH grant to build software tools to predict cancer drug efficacy

Higher hemoglobin threshold does not improve outcomes in preterm infants

Study: Frailty is a risk factor among women waiting for liver transplants

Phase 3 results show investigational vaccine is effective in preventing severe COVID-19

Protein employs twist‐and‐squeeze mechanism to expel chemotherapeutics from cancer cells

Study offers explanation for silent hypoxemia in COVID-19 patients

Large transporter protein dysfunction associated with schizophrenia

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Phase 3 trial of Novavax COVID-19 vaccine candidate begins enrolling volunteers

Researchers develop new drug discovery method targeting membrane proteins on live cells

Surgery may increase length of survival for metastatic breast cancer patients

Researchers develop new system for direct detection of SARS-CoV-2 in aerosols

Protein encourages similar developing cells to clump together

Severity of COVID-19 correlates with the ratio of antibodies targeting crucial viral protein

SARS-CoV-2 spike-antibody binding strength and hydrogen bond numbers are temperature dependent, study finds

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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