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Researchers describe underlying mechanisms of congestive heart failure

Congestive heart failure is a terminal disease that affects nearly 6 million Americans. Yet its management is limited to symptomatic treatments because the causal mechanisms of congestive heart failure -- including its most common form, ischemic cardiomyopathy -- are not known.

10 Aug 2018

Researchers use guide RNAs to improve base editing system

Researchers have used guide RNAs to improve the adenine base editing (ABE) system, used by scientists to alter genetic codes in animal models of disease.

1 Aug 2018

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

Inflammation is part of the body's natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer's disease and other conditions.

26 Jul 2018

Simple DNA test can predict risk of bad side effects to thiopurine drugs

Screening a tiny section of DNA could help East Asian patients avoid severe reactions to some medications.

2 Jul 2018

Research identifies new genetic variations that could indicate higher prostate cancer risk

As the result of a six-year long research process, Fredrick R. Schumacher, PhD, a cancer epidemiology researcher at Case Western Reserve University School of Medicine, and an international team of more than 100 colleagues have identified 63 new genetic variations that could indicate higher risk of prostate cancer in men of European descent.

12 Jun 2018

New shape of DNA found in human cells

DNA double helix discovery is one of the major breakthroughs in human scientific history. Now in a new research, scientists have found that there may be another new shape in the DNA machinery within the cells of humans.

25 Apr 2018

Biomarker panel can guide future therapeutic decisions for glioma patients

In an article published April 10th in the journal Cell Reports, researchers at the University of São Paulo describe a biomarker panel that could tell physicians which patients diagnosed with glioma, a type of brain cancer, will tend to progress to a more aggressive form of the disease in the event of relapse.

10 Apr 2018

Researchers probe RNA epigenetics and chromatin structures to predict drug resistance in leukemia

Drug resistance is a major obstacle to effective treatment for patients with cancer and leukemia. Epigenetic modifying drugs have been proven effective for some patients with hematologic malignancies, such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).

23 Mar 2018

Researchers develop technology to program DNA for delivering cancer drugs

DNA has an important job – it tells your cells which proteins to make. Now, a research team at the University of Delaware has developed technology to program strands of DNA into switches that turn proteins on and off.

19 Mar 2018

Quiescent cells also acquire particular type of mutation, research shows

For almost a hundred years, geneticists have believed that the more a cell divides the more mutations it acquires. However, research by scientists at the Institut Pasteur shows that quiescent cells, which do not divide, also acquire a particular type of mutation - deletions (mutations through loss of nucleobases).

27 Feb 2018

Researchers uncover new details about function of enigmatic protein

In a recent study, a research group at MedUni Vienna has published further details about the function of an enigmatic protein. The biological necessity of this protein, which can chemically alter certain building blocks of the genetic information, has been debated for quite a while.

14 Feb 2018

Researchers solve crystal structure for enzyme that plays key role in DNA methylation

A research team led by a biochemist at the University of California, Riverside has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl groups are added to the DNA molecule.

7 Feb 2018

Study reveals the mechanism of common DNA mutations

Researchers at The Ohio University have uncovered the mechanism by which thymine and guanine, the most commonly mutated bases in DNA, become damaged.

2 Feb 2018

Genes in Space-3 team identifies microbes in real time aboard the space station

Being able to identify microbes in real time aboard the International Space Station, without having to send them back to Earth for identification first, would be revolutionary for the world of microbiology and space exploration.

29 Dec 2017

Epigenetics: A New Tool for Forensic Detectives

Developing analytical methods can help the triers of fact, judges and juries, better understand the events surrounding the circumstances of a crime. In forensic analysis, we are talking about determining the identity of unknown individuals through DNA and using DNA and other chemical signatures to determine and clarify the circumstances of the crime.

From Pittcon 20 Dec 2017

Clinical trial shows promising results for treatment of patients with recurrent high-grade glioma

New data from a Phase I clinical trial led by Clark Chen, M.D., Ph.D., Lyle French Chair in Neurosurgery and Head of the University of Minnesota Medical School Department of Neurosurgery shows more than a quarter of patients with recurrent high-grade glioma, a form of brain cancer, were alive more than three years after treatment.

28 Oct 2017

New enzyme may one day enable genome surgery that erases harmful mutations

DNA editing just got a sharp, new pencil. Researchers have built an enzyme that can perform a previously impossible DNA swap, directly changing the DNA base pair from an A•T to a G•C.

26 Oct 2017

CRISPR - a genetic editor - used to edit DNA and RNA in two parallel studies

Two different studies have shown that CRISPR - a gene editing tool, could be the next big thing in manipulating and modifying the DNA to suit the needs.

26 Oct 2017

Mysterious DNA modification appears more in the brain under stress

With advances in genomics, scientists are discovering additional components of the DNA alphabet in animals. Do these unusual chemical modifications of DNA have a special meaning, or are they just signs that cellular machines are making mistakes?

24 Oct 2017

Space radiation causes long-term health consequences for astronauts

While people protect their eyes from the sun's radiation during a solar eclipse, NASA's Human Research Program is working to protect the whole human body from radiation in space. Space radiation is dangerous and one of the primary health risks for astronauts.

21 Sep 2017