Mania News and Research

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Mice without specific brain chemical develop characteristics similar to bipolar disorder, shows study

Mice that have a particular brain chemical switched off become hyperactive and sleep for just 65 per cent of their normal time.

29 Jul 2015

Allergan announces U.S. availability of SAPHRIS 2.5 mg tablets for children with bipolar I disorder

Allergan plc today announced that SAPHRIS (asenapine) 2.5 mg sublingual (placed under the tongue) black-cherry flavored tablets are available in pharmacies throughout the U.S. In March 2015, the U.S. Food and Drug Administration approved SAPHRIS for the acute treatment of manic or mixed episodes associated with bipolar I disorder in pediatric patients (ages 10 – 17).

17 Jul 2015

Cognizin citicoline shows promise in patients with bipolar disorder and cocaine dependence

The results of a randomized, double-blind, placebo-controlled clinical trial showed that Cognizin citicoline (Jarrow Formulas) was effective at reducing cocaine use, based on urine drug screens, in patients with bipolar disorder and cocaine dependence. The study, published in the American Journal of Psychiatry in Advance, included a total of 130 outpatients with bipolar I disorder and cocaine dependence, who received either Cognizin citicoline or placebo add-on therapy for 12 weeks.

7 Jul 2015

Poor sleep linked to negative mood in women with bipolar disorder

Poor sleep is associated with negative mood in women with bipolar disorder, according to researchers at Penn State College of Medicine and University of Michigan Medical School.

30 Jun 2015

Upsher-Smith announces FDA approval of sNDA for Qudexy XR extended-release capsules

Upsher-Smith Laboratories, Inc. announced that it has received U.S. Food and Drug Administration approval of a supplemental new drug application (sNDA) for Qudexy XR (topiramate) extended-release capsules for use as initial monotherapy in patients two years of age and older who are experiencing partial-onset seizures (POS) or primary generalized tonic-clonic seizures.

2 Jun 2015

Manic symptoms during depression warn of polarity switch

Concomitant manic symptoms and panic attacks are the strongest predictors of an impending switch to mania among patients with bipolar disorder who are currently depressed, shows analysis of the STEP-BD study.

27 May 2015

Aptensio XR once-daily treatment for ADHD to be available in Summer 2015

Today, Rhodes Pharmaceuticals L.P. announced that Aptensio XR, a once-daily central nervous system stimulant indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) will be available to patients beginning Summer 2015.

22 May 2015

Orexigen Therapeutics provides update on business and financial results for Q1 2015

Orexigen Therapeutics, Inc. today announced business and financial results for the first quarter ended March 31, 2015.

8 May 2015

New study reveals that psychiatric disorders don't predict future violent behavior

Most psychiatric disorders - including depression -- do not predict future violent behavior, according to new Northwestern Medicine longitudinal study of delinquent youth. The only exception is substance abuse and dependence.

25 Apr 2015

Upsher-Smith presents favorable data from PREVAIL OLE study of Qudexy XR capsules

Upsher-Smith Laboratories, Inc. presented data from a 52-week, open-label extension study (PREVAIL OLE) showing that Qudexy XR (topiramate) extended-release capsules offered a long-term adjunctive treatment option with a favorable tolerability profile for a high proportion of patients with refractory partial-onset seizures (POS).

21 Apr 2015

Subthreshold mania signals impending bipolarity in children of bipolar patients

Subthreshold manic or hypomanic symptoms frequently precede clinical mood episodes in the children of patients with the condition, a study shows.

24 Mar 2015

Study shows strong link between subthreshold manic episodes and bipolar disorder in children

New research published today in the American Journal of Psychiatry indicates a strong link between subthreshold manic episodes and likelihood of developing bipolar disorder in children of parents with bipolar disorder. The study's findings could improve clinical assessment and care for these high-risk children by potentially enabling earlier identification, treatment or possible preventive measures.

3 Mar 2015

Researchers suggest significant relationship between cannabis use and mania symptoms

Researchers from the University of Warwick have found evidence to suggest a significant relationship between cannabis use and the onset and exacerbation of mania symptoms.

11 Feb 2015

Atypical features common in bipolar disorder subtypes, associated with therapy

Atypical features are prevalent in all subtypes of bipolar disorder, a Chinese survey published in Neuroscience Bulletin, shows, and are associated with the use of antidepressant medication in patients with mixed stage and remission subtypes.

30 Jan 2015

State and federal prisoners not receiving adequate mental health care

A significant portion of state and federal prisoners are not receiving treatment for mental health conditions, according to research by The University of Texas Health Science Center at Houston School of Public Health.

12 Jan 2015

Bipolar brain changes both state- and trait-dependent

Some of the alterations in brain activation in patients with bipolar disorder are dependent on their current mood, study findings show.

17 Dec 2014

Quitting cannabis use during manic episodes improves outcomes

A post-hoc analysis of data from a prospective European study reveals that patients with bipolar disorder who stop using cannabis during a manic or mixed episode have similar clinical and functional outcomes to those who have never used the drug.

9 Dec 2014

UC Berkeley study finds self-worth key to diagnoses of psychopathologies

Donald Trump's ego may be the size of his financial empire, but that doesn't mean he's the picture of mental health. The same can be said about the self-esteem of people who are living from paycheck to paycheck, or unemployed. New research from the University of California, Berkeley, underscores this mind-wallet connection.

8 Dec 2014

Depressive episodes hard to treat in continuous cycling bipolar disorder

Patients with bipolar disorder who switch directly between mania and depression without a period of euthymia have a poor response to short-term antidepressant treatment, study findings indicate.

3 Dec 2014

Bipolar mixed episodes increase significantly under DSM-5

Using the most recent diagnostic criteria increases the prevalence of mixed features in patients with bipolar disorder more than threefold, study findings indicate.

13 Nov 2014