Pathophysiology News and Research

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2025 Best Practices Update released for managing MS in a changing landscape

Keeping up with scientific advances and practice changes can be one the biggest challenges in managing a complex disease like multiple sclerosis (MS).

17 Apr 2025

Best time for asthma meds? Try 4 pm

Chronotherapy for asthma reveals that afternoon inhaled corticosteroids significantly improve lung function and reduce nighttime symptoms without side effects.

17 Apr 2025

New hope for sclerosteosis patients through Wnt pathway inhibition

Sclerosteosis arises from mutations in the SOST gene, causing abnormally high bone mass and skeletal overgrowth, which can lead to severe health issues such as hearing loss and increased intracranial pressure.

16 Apr 2025

Promising findings for the treatment of patients with pulmonary arterial hypertension with a high risk of mortality

Pulmonary arterial hypertension (PAH) is a rare and severe lung disease with a life-threatening prognosis. After several positive trials, a recent study has confirmed the efficacy of a biotherapy, sotatercept.

16 Apr 2025

Study reveals a potential breakthrough in treating osteonecrosis of the femoral head

A recent study has uncovered a potential breakthrough in treating osteonecrosis of the femoral head (ONFH), a debilitating bone disease that causes severe pain and joint collapse.

15 Apr 2025

Could your milk choice affect migraines?

Skim milk consumption is linked to a lower prevalence of migraines in U.S. adults, according to a large NHANES-based study. The association remained significant even after adjusting for lifestyle, diet, and demographic factors.

9 Apr 2025

Gut microbes and metabolites reveal how lifestyle changes help prevent type 2 diabetes

Researchers identified 502 blood metabolites linked to prediabetes and type 2 diabetes, with 143 tied to the gut microbiome. The study shows how lifestyle interventions like diet and exercise can modify metabolomic profiles to support glucose control.

9 Apr 2025

Study reveals sex differences in bone regeneration

Bone regeneration continues to be a critical challenge in tissue engineering, with unpredictable outcomes often hindering clinical application. Current strategies overlook key factors such as donor differences and biological sex, both of which play a significant role in fracture healing.

9 Apr 2025

Study links neurotensin deficiency to ovulatory dysfunction in PCOS

Polycystic ovary syndrome (PCOS) represents a significant health concern for women of reproductive age, manifesting as a complex endocrine disorder with diverse clinical presentations.

3 Apr 2025

Pregnancy linked to lower long COVID risk in study of over 70,000 women

Pregnant women who contract SARS-CoV-2 may have a lower risk of developing Long COVID than matched non-pregnant women.

2 Apr 2025

WARRIOR trial finds no impact of intensive therapy on heart events in women

An intensive three-drug regimen of heart medications did not significantly impact the rate of serious cardiovascular events at five years in women who experienced signs and symptoms of ischemia, or insufficient blood flow to the heart muscle, but had no blockages in their heart's arteries, according to research presented at the American College of Cardiology's Annual Scientific Session.

29 Mar 2025

$Unraveling CD47's role in bone fracture healing$

Unraveling CD47's role in bone fracture healing

Bone fracture healing is a highly coordinated process involving inflammation, fibrovascular formation, and mineralization.

27 Mar 2025

Exploring the therapeutic potential of flavonoids in type 2 diabetes

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with a rapidly increasing global prevalence. It is primarily characterized by insulin resistance, β-cell dysfunction, and impaired glucose homeostasis.

20 Mar 2025

New enzyme target could lead to breakthrough therapies for Lyme disease

Researchers have discovered that an enzyme can serve as an ideal target for developing new therapeutics against Lyme disease, and most likely other tick-borne diseases as well.

20 Mar 2025

New study challenges traditional view of functional dyspepsia and gastroparesis

Functional dyspepsia (FD) and gastroparesis (GP) are gastrointestinal disorders often managed as separate conditions.

18 Mar 2025

Probiotic drink kefir shows promise in preventing Alzheimer’s

Kefir, a probiotic-rich fermented milk, shows potential in reducing neuroinflammation, oxidative stress, and beta-amyloid buildup, suggesting a role in Alzheimer’s prevention and management. However, more clinical trials are needed to confirm its effectiveness in human patients.

17 Mar 2025

Impact of excessive alcohol consumption on digestive health

Excessive alcohol consumption is a significant public health concern, responsible for approximately 6% of all deaths and contributing to 5.1% of the global disease burden.

12 Mar 2025

3D imaging sheds light on how nerves and blood vessels in the skull decline with age

As the body ages, bones undergo changes that can hinder their ability to regenerate and heal. While previous studies have concentrated on the structural shifts in bone tissue itself, the role of nerves and blood vessels—critical players in bone health—has remained relatively unexplored.

11 Mar 2025

Study reveals genes critical for tuberculosis survival during transmission

Tuberculosis bacteria rely on a family of genes that help them survive the challenging journey from one person's lungs to another person's during coughing, sneezing or talking, according to researchers from Weill Cornell Medicine and the Massachusetts Institute of Technology.

10 Mar 2025

New insights into miRNA roles in diabetic cardiomyopathy immune regulation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetic cardiomyopathy (DCM), an independent diabetes complication, is characterized by abnormalities in myocardial structure, function, and metabolism, including diminished myocardial contractility, myocardial hypertrophy, and fibrosis.

5 Mar 2025