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The immunometabolic regulatory mechanisms for the pathogenesis of COVID-19

A new study aimed to analyze the immunometalobism BALF cells from mild to severe COVID-19 patients using computational algorithms that quantified metabolic fluxes and metabolic pathways.

13 Oct 2022

Vaccine-induced neutralizing and non-neutralizing antibody activity against SARS-CoV-2

A new study demonstrated that vaccine-induced antibody functions against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diminish with age.

7 Oct 2022

Study reveals immune characteristics of long-COVID

Researchers perform antibody profiling against SARS-CoV-2, several endemic pathogens, as well as vaccine antigens among rheumatic disease patients.

2 Oct 2022

UAB study finds distinct kidney resident macrophage subpopulations located in spatially discrete microenvironments

Macrophages are immune cells that engulf and digest pathogens, cancer cells or cellular debris. The kidneys - like other tissues in the body - contain kidney resident macrophages, or KRMs, from the time of birth.

28 Sep 2022

Vaccination drives superior functional antibody breadth compared to natural infection with SARS-CoV-2

Researchers assessed the potency and breadth of antibody recognition and effector function among healthy and high-risk individuals following natural SARS-CoV-2 infection or mRNA COVID-19 vaccination.

21 Sep 2022

The evolution of humoral immune responses over the course of Epstein-Barr virus infection

Researchers explored probable humoral immune mechanisms related to EBV curtailment, besides neutralization, by a systematic emphasis on antibody fragment crystallizable-functional activities over the course of EBV infections.

9 Sep 2022

Insights into the biology of the monkeypox virus

Researchers provided insights into monkeypox virus structural characteristics, epidemiology, transmission, zoonotic reservoirs, pathogenesis, and clinical management.

23 Aug 2022

How do BNT162b2 vaccine-induced neutralizing and non-neutralizing antibodies synergize to promote protection against SARS-CoV-2?

Scientists explored the COVID-19 BNT162b2 vaccine triggered non-neutralizing and neutralizing antibody functions.

18 Aug 2022

The efficacy of therapeutic monoclonal antibodies and serum from monoclonal antibody-treated patients against Omicron sublineages

Researchers evaluated the neutralization of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 sub-variants by therapeutic monoclonal antibodies.

16 Aug 2022

Researchers challenge a popular scenario put forward to explain the arrival of the first eukaryotic organisms

In the beginning, there was boredom. Following the emergence of cellular life on earth, some 3.5 billion years ago, simple cells lacking a nucleus and other detailed internal structure dominated the planet. Matters would remain largely unchanged in terms of evolutionary development in these so-called prokaryotic cells - the bacteria and archaea - for another billion and a half years.

8 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

Persistent viral infections within hosts cause post-acute sequelae of COVID-19, research shows

A research team, comprised of Associate Professor Tomonari Sumi of the Research Institute for Interdisciplinary Science at Okayama University and Associate Professor Kouji Harada of the Center for IT-based Education at Toyohashi University of Technology, has developed a mathematical model of the immune response within infected hosts that considers systemic infection of a novel coronavirus (SARS-CoV-2), and demonstrated by conducting experimental computer simulations that persistent viral infections within hosts potentially cause long COVID or post-acute sequelae of COVID-19.

3 Aug 2022

Study explores differential antibody-mediated effector functions evoked by two mRNA-based COVID-19 vaccines

Researchers evaluated the differential humoral immune response to two COVID-19 vaccines - messenger ribonucleic acid (mRNA)-1273 and BNT162b2.

2 Aug 2022

The identification and characterization of an anti-SARS-CoV-2 monoclonal antibody with superior breadth and potency

A recent study published in Nature Microbiology identified a monoclonal antibody neutralizing SARS-CoV-2 Omicron variants.

28 Jul 2022

COVID-19 Moderna vaccine induces significant antibody reactions among children

Researchers illustrated that SARS-CoV-2 messenger ribonucleic acid vaccination triggers potent antibody reactions in children.

28 Jul 2022

Maternal antibodies may play a key role in protecting infants from congenital HCMV infections

Antibodies that summon virus-engulfing white blood cells may play an important role in protecting infants from potentially serious congenital infection with human cytomegalovirus (HCMV), according to a study led by an investigator at Weill Cornell Medicine and NewYork-Presbyterian.

22 Jul 2022

Pigment epithelium-derived factor ablations may lead to eye aging

Researchers identified that loss of pigment epithelium-derived factor (PEDF) may cause aging in the eye.

21 Jul 2022

Immunoglobulin G isotypes switch class following repeated SARS-CoV-2 mRNA vaccination

Researchers reported a class switch in SARS-CoV-2-specific antibodies due to repeated mRNA vaccinations.

13 Jul 2022

Scientists investigate impact of SARS-CoV-2 RBD mutations across variants

In a recent study posted to the medRxiv* pre-print server, Australian researchers comprehensively investigated the impact of 39 receptor-binding-domain (RBD) mutations in six severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and variants of interest (VOIs).

12 Jul 2022

Persistence of SARS-CoV-2 in tissues leads to long COVID

PASC is likely the result of long-term persistence of SARS-CoV-2 in various tissues

11 Jul 2022