Single Nucleotide Polymorphisms News and Research

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Genetic link between migraines and breast cancer risk uncovered

Using Mendelian randomization analysis, the study finds a genetic link between migraine susceptibility and increased risk of overall and estrogen receptor-positive breast cancer. However, the findings suggest caution in interpretation, highlighting the need for further research to solidify these associations.

24 Sep 2023

How important is inflammation and body weight in the origin of depression?

A new paper in BMC Medicine examines the role of inflammation and body mass index (BMI) in the etiology of treatment-resistant depression.

18 Sep 2023

Smoking can accelerate the process of aging, study shows

A study of nearly 500,000 people has shown that smoking shortens the end fragments of chromosomes in the white blood cells of our immune systems.

12 Sep 2023

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

The study used a genome-wide association study (GWAS) to analyze random glucose levels in nearly half a million non-diabetic subjects, uncovering 150 distinct genetic signals, including 53 new ones, linked to glycemic traits and type 2 diabetes. The research also discovered a causal effect of random glucose and type 2 diabetes on lung function, identifying lung dysfunction as a new diabetes complication.

10 Sep 2023

Study explores the role of sex on mRNA and protein levels and its genetic regulation in brain

Researchers investigated the impact of biological sex on protein levels and its genomic control by analyzing 1,277 proteomes of the brain.

4 Sep 2023

The first point-of-care genetic test for lactose intolerance: A compact, lab-on-phone diagnostic assay

The performance of a compact diagnostic assay that can accurately and rapidly diagnose lactose intolerance.

4 Sep 2023

Is obesity associated with risk of head and neck cancer?

The association between obesity and head and neck cancer risk.

29 Aug 2023

Beyond health records: Deep learning enhances disease diagnosis via image-based phenotyping

Researchers explored the use of image-based phenotyping based on dual-energy X-ray absorptiometry (DXA) scans.

28 Aug 2023

Can vitamins really fight cancer? New study uncovers surprising links between micronutrients and cancer risk

The study uses Mendelian randomization to examine the relationship between 14 micronutrients and 22 cancer outcomes, finding significant associations between higher magnesium and vitamin B12 levels and increased risks of breast and colorectal cancers, respectively.

27 Aug 2023

The value of whole-exome sequencing as a first-tier genetic test in the diagnosis of skin disorders

The genetic etiology by whole-exome sequencing (WES).

23 Aug 2023

The causal effect of gut microbiota on psoriasis

The potential relationship between gut microbiota and different subtypes of psoriasis.

22 Aug 2023

Genetic determinants of retinol circulation and their impact on health

The genetic architecture of circulating retinol.

15 Aug 2023

Exploring DNA methylation biomarkers of multiple sclerosis

Researchers identify cell-specific DNA methylation signatures associated with MS.

14 Aug 2023

Identification of plasma proteins associated with ovarian cancer risk

Researchers performed proteomic Mendelian randomization as well as co-localization analyses to identify drug targets for ovarian cancer.

8 Aug 2023

Neoantigen discovery sheds light on cancer immunogenicity

Researchers reported a proteogenomic approach to investigate fresh solid melanoma tumor material.

4 Aug 2023

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Study aimed to understand the specific needs of lung cancer in never smokers (LCINS) patients.

25 Jul 2023

New biosensor could quickly and inexpensively identify people at risk for osteoporosis

As life expectancy increases worldwide, age-associated diseases such as osteoporosis are having an increasing impact.

19 Jul 2023

The infection connection: investigating the impact on dementia risk, neuroimaging reveals

Researchers compared the association between neuroimaging markers of dementia and antibodies to common infection.

17 Jul 2023

Researchers demonstrate targeted epigenome editing in the promoter region of several genes using sgRNA/dCas9 complexes

Researchers develop and characterize a highly specific EpiEditing system using catalytically inactivated catalytically inactivated Cas9.