Triple Negative Breast Cancer News and Research

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Study identifies targetable fusion RNAs in breast cancer

Comprehensive profiling of fusion RNAs present in a large cohort of metastatic breast tumors revealed unique fusion mutations that may be therapeutically targetable, according to results presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

8 Dec 2023

Study finds link between epimutations in BRCA1 gene and triple-negative breast cancer risk

Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene.

7 Dec 2023

New artificial intelligence algorithms facilitate diagnosis of difficult cancers

New artificial intelligence algorithms are developed to facilitate the diagnosis and treatment of cancerous tumors that are difficult to interpret clinically.

27 Nov 2023

New insights into genetic risk factors for early breast cancer in women of Kazakh ethnicity

A new research paper was published in Oncotarget's Volume 14 on October 4, 2023, entitled, "Determination of genetic predisposition to early breast cancer in women of Kazakh ethnicity."

22 Nov 2023

St. Jude scientists discover potential CAR T cell therapy target for brain and solid tumors

Findings from St. Jude Children's Research Hospital are moving the field of cancer immunotherapy one step closer to treating brain and solid tumors.

21 Nov 2023

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.

8 Nov 2023

The association between neighborhood deprivation, DNA methylation, and gene expression in breast tissue for Black and White women with breast cancer

Researchers investigated the association between neighborhood deprivation and alterations in DNA methylation and gene expression in breast cancer tissues of Black and White women.

7 Nov 2023

Promising new drug target for triple-negative breast cancer identified

Improving treatments for triple-negative breast cancer (TNBC), an aggressive tumor with very poor prognosis and limited therapeutic targets, has been challenging.

30 Oct 2023

Finding and targeting dormant tumor cells to prevent breast cancer recurrence

While breast cancer survival continues to improve, thanks to advances in detection and treatment, when breast cancer recurs – or returns after initial treatment – it is incurable.

24 Oct 2023

Researchers discover new way to trigger programmed cell death in cancer cells

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.

24 Oct 2023

Researchers develop experimental vaccine to prevent spread of metastatic cancers to the lungs

Engineers at the University of California San Diego have developed an experimental vaccine that could prevent the spread of metastatic cancers to the lungs.

18 Oct 2023

Insilico Medicine to present scientific data on novel anti-cancer assets at major cancer conferences

Clinical stage artificial intelligence (AI) drug discovery company Insilico Medicine ("Insilico") has been invited to present scientific data on its novel anti-cancer assets at three major upcoming cancer conferences -- the European Society for Medical Oncology (ESMO) conference in Madrid Oct. 20-24, 2023; the Society of Immunotherapy of Cancer (SITC) conference Nov. 1-5, 2023 in San Diego; and the San Antonio Breast Cancer Symposium (SABCS) Dec. 5-9, 2023.

16 Oct 2023

New nanocapsule treatment boosts immune response against solid tumors

UCLA researchers have developed a new treatment method using a tiny nanocapsule to help boost the immune response, making it easier for the immune system to fight and kill solid tumors.

11 Oct 2023

Discovery of a novel therapeutic target for pancreatic cancer

A novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

10 Oct 2023

Researchers discover a vulnerability in immunotherapy-resistant triple-negative breast cancer

Researchers at Vanderbilt-Ingram Cancer Center have discovered a druggable target on natural killer cells that could potentially trigger a therapeutic response in patients with immunotherapy-resistant, triple-negative breast cancer.

5 Oct 2023

New discovery could delay relapse in triple-negative breast cancer

A team of researchers at the Medical University of Vienna has discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein called P-glycoprotein (P-gp).

3 Oct 2023

Neoadjuvant immunotherapy shows promise in multiple cancer types

Treating cancer with immunotherapies known as an immune checkpoint blockade (ICB) prior to surgery (so-called neoadjuvant immunotherapy) has been a rapidly growing area of research, but the scientific community is just scratching the surface of what is possible, according to a review article co-authored by several current and former investigators from the Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Kimmel Cancer Center.

28 Sep 2023

Radiation therapy combined with two types of immunotherapy could be effective against cold tumors

Researchers at Weill Cornell Medicine have discovered that radiation therapy combined with two types of immunotherapy - one that boosts T cells, and another that boosts dendritic cells - can control tumors in preclinical models of triple negative breast cancer, a cancer type that's typically resistant to immunotherapy alone.

25 Sep 2023

Research demonstrates a double-acting mechanism for fighting triple-negative breast cancer

Zachary Schug, Ph.D., assistant professor in the Molecular and Cellular Oncogenesis Program of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute, has published a new paper in the journal Nature Cancer.

19 Sep 2023

Swedish study changes national guidelines for genetic testing in breast cancer

BRCA1 and BRCA2 are well-known breast cancer genes associated with a significantly increased risk of hereditary breast and ovarian cancer. However, there are an additional eleven genes associated with elevated risk for these types of cancer.

23 Aug 2023