Nucleotides News and Research

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RNA interference can be used to silence genes selectively - potential for Huntington's disease therapy

Howard Hughes Medical Institute researchers have designed tiny RNA molecules that shut off the gene that causes Huntington's disease without damaging that gene's healthy counterpart, which maintains the health and vitality of neurons.

12 Apr 2009

Genetic variation found to increase risk of schizophrenia

Rutgers geneticist Linda Brzustowicz and her colleagues have identified a specific DNA change that is likely to increase risk for developing schizophrenia in some people.

8 Apr 2009

Mutations within a conservative region of hepatitis C virus affect therapy

At least 200 million individuals are currently infected with hepatitis C virus (HCV) worldwide.

30 Mar 2009

Hundreds of published studies on natural selection may have drawn incorrect conclusions

Scientists at Penn State and the National Institute of Genetics in Japan have demonstrated that several statistical methods commonly used by biologists to detect natural selection at the molecular level tend to produce incorrect results.

30 Mar 2009

Potential therapeutic strategy for fulminant hepatic failure

Fulminant hepatic failure is a serious clinical disease and may threaten the life of patients. However, because of the damage of mass liver cells, the organ function is often irreversible due to the liver cell degeneration, swelling, or apoptosis.

30 Mar 2009

Mutations in a gene may stunt lung development in children

Mutations in a gene may cause poor lung development in children, making them more vulnerable to diseases such as chronic obstructive pulmonary disease (COPD) later in life, say researchers at the University of Pittsburgh Graduate School of Public Health and the German Research Center for Environmental Health.

29 Mar 2009

Omega-3 fatty acids appear protective against advanced prostate cancer

Omega-3 fatty acids appear protective against advanced prostate cancer, and this effect may be modified by a genetic variant in the COX-2 gene, according to a report in Clinical Cancer Research , a journal of the American Association for Cancer Research.

24 Mar 2009

Scientists make a new protein from scratch

No doubt proteins are complex. Most are "large" and full of interdependent branches, pockets and bends in their final folded structure.

23 Mar 2009

Common gene variations found to influence risk factor for sudden cardiac death

A new study has identified several common genetic variants related to a risk factor for sudden cardiac death.

23 Mar 2009

Quantum effect may hold promise for low-cost DNA sequencing, sensor applications

A ghostly property of matter, called quantum tunneling, may aid the quest for accurate, low-cost genomic sequencing, according to a new paper in Nature Nanotechnology Letters by Stuart Lindsay and his collaborators at the Biodesign Institute of Arizona State University.

22 Mar 2009

A new approach for detecting functional genomic regions

A team that includes researchers from the National Institutes of Health (NIH) has found a new way of detecting functional regions in the human genome. The novel approach involves looking at the three-dimensional shape of the genome's DNA and not just reading the sequence of the four-letter alphabet of its DNA bases.

12 Mar 2009

Smokers' chronic obstructive pulmonary disease risk is genetic

It's well known that puffing on cigarettes can eventually leave you out of puff.

11 Mar 2009

Genetic mutations suggest link between type 1 diabetes and common viral infection

Scientists from Cambridge University have discovered four rare mutations of a gene associated with type 1 diabetes (T1D) that reduce the risk of developing the disease.

5 Mar 2009

Discovery of new gene that causes Leber congenital amaurosis and retinitis pigmentosa

The team of Dr. Robert Koenekoop which includes Dr. Irma Lopez from the Research Institute of the MUHC at the Montreal Children's Hospital played a crucial role in the international collaboration that led to the discovery of a new gene that causes Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP), two devastating forms of childhood blindness.

5 Mar 2009

New software aids discovery of new genetic markers for diseases

Modern genotyping technologies offer new opportunities to explore how genes influence health and disease, but also present the challenge of analyzing huge amounts of genetic and clinical data.

26 Feb 2009

Novel approach to gene hunting uncovers possible new targets for Crohn's disease drugs

Discovering the different genes that contribute to a complex disease is like searching in the proverbial haystack for an unknown number of needles--some much smaller than others, often blending into the background, and many of them widely separated from each other.

26 Feb 2009

New statistical model could predict an individual's lifetime risk of stroke

Using genetic information from 569 hospital patients, the researchers showed that their predictive model could estimate an individual's overall risk of cardioembolic stroke -- the most common form of stroke -- with 86 percent accuracy. The findings are reported in the March issue of Stroke.

25 Feb 2009

Nucleotides News and Research

RNA interference can be used to silence genes selectively - potential for Huntington's disease therapy

Genetic variation found to increase risk of schizophrenia

Mutations within a conservative region of hepatitis C virus affect therapy

Hundreds of published studies on natural selection may have drawn incorrect conclusions

Potential therapeutic strategy for fulminant hepatic failure

Mutations in a gene may stunt lung development in children

Omega-3 fatty acids appear protective against advanced prostate cancer

Scientists make a new protein from scratch

Common gene variations found to influence risk factor for sudden cardiac death

Quantum effect may hold promise for low-cost DNA sequencing, sensor applications

A new approach for detecting functional genomic regions

Smokers' chronic obstructive pulmonary disease risk is genetic

Genetic mutations suggest link between type 1 diabetes and common viral infection

Discovery of new gene that causes Leber congenital amaurosis and retinitis pigmentosa

New software aids discovery of new genetic markers for diseases

Novel approach to gene hunting uncovers possible new targets for Crohn's disease drugs

New statistical model could predict an individual's lifetime risk of stroke

Oxford Nanopore announces publication of DNA analysis paper

Handheld device provides on-the-spot DNA analysis to test tolerance to prescription drugs

Common gene variants increase risk of hypertension, may lead to new therapies

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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