Pathophysiology News and Research

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New insights into filaminopathies

New insights into certain muscle diseases, the filaminopathies, are reported by an international research team led by Dr. Rudolf Andre Kley of the RUB's University Hospital Bergmannsheil in the journal Brain.

26 Sep 2012

Low aerobic fitness risk factor for chronic kidney disease in men

Young men with low levels of aerobic fitness are more likely to have albuminuria or glomerular hyperfiltration, both early signs of chronic kidney disease, than those with higher levels of fitness.

24 Sep 2012

Non-burns specialist nurses rely on experience rather than evidence for treatment

Clinical guidance in the UK on treating minor burns can be contradictory. Some researchers argue blister fluid can help wound healing and blisters should be left intact while others say blisters need to be removed to avoid infection. A study has found non-burns specialist nurses, who treat minor burns patients in accident and emergency and urgent care units rely on experience rather than evidence for treatment.

24 Sep 2012

Early menopause increases cardiovascular risk

Women who reach the menopause early have a doubled risk for coronary heart disease and stroke, study findings show.

20 Sep 2012

Migraine headaches in children linked to behavioral difficulties

Kids who get migraine headaches are much more likely than other children to also have behavioral difficulties, including social and attention issues, and anxiety and depression. The more frequent the headaches, the greater the effect, according to research out now in the journal Cephalagia, published by SAGE.

17 Sep 2012

Dual role of ghrelin in anxiety behavior is context-dependent

Ghrelin is a hormone released by the lining of the stomach that promotes feeding behavior. Decreasing ghrelin levels could potentially help combat obesity -- in fact, a vaccine that lowers ghrelin levels in order to reduce appetite is being studied as a treatment for obesity.

14 Sep 2012

Women at increased risk of adverse outcomes after surgery for moyamoya disease

Women and girls are at increased risk of adverse outcomes after surgical treatment for moyamoya disease, an uncommon but serious disease of the brain blood vessels, reports a study in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

10 Sep 2012

Concussion: an interview with Dr Rob Reid

Concussion happens when something produces a concussive force to the head, such as a blow to the head. The definition from the 2008 consensus, which was in Zurich, is, “concussion is defined as a complex pathophysiological process affecting the brain, induced by traumatic biomechanical forces.”

10 Sep 2012

Strategic roadmap to help cope with impending Alzheimer's disease public health crisis

This week, a strategic roadmap to help to the nation's health care system cope with the impending public health crisis caused Alzheimer's disease and related dementia will be published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

7 Sep 2012

On-the-spot test aids postsurgical coagulopathy management

Point-of-care thromboelastometric and aggregometric testing helps to reduce exposure to allogenic blood products in patients with coagulopathy after cardiac surgery, a randomized trial shows.

5 Sep 2012

Brain derived neurotrophic factor level indicates childhood obesity risk

Brain derived neurotrophic factor may play an important role in the development and pathophysiology of childhood obesity, report researchers.

4 Sep 2012

Data from ESTEVE’s S1RA E-52862 Phase I trial programme on pain

ESTEVE announces the recent publication of data from the Phase I clinical trial programme of a novel, highly potent and selective, once-daily, S1RA E-52862, developed by the ESTEVE R&D team, in the British Journal of Clinical Pharmacology.

4 Sep 2012

GeneTex to introduce new antibody against hypoxia-inducible factor 1alpha

GeneTex, Inc., a leading manufacturer of antibodies, has announced that they will be launching a new antibody against HIF1a (hypoxia-inducible factor 1alpha).

29 Aug 2012

Friedreich Ataxia Research Alliance, USF ARC to host ‘Understanding a Cure’ symposium

Scientists, clinicians and patients will gather at the University of South Florida's Center for Advanced Medical Learning and Simulation (CAMLS) in downtown Tampa Sept. 6 to share research insights and energize the search for a cure for Friedreich's ataxia and related disorders.

28 Aug 2012

Renal denervation leads to better outcomes than standard drug treatment in patients with AHF

Renal denervation leads to better outcomes than standard drug treatment in patients with advanced heart failure, according to research presented at ESC Congress 2012. The results of the Olomouc I pilot study were presented by Dr Miloš Táborský from the University Hospital Olomouc.

27 Aug 2012

Study explores gender-related differences in patients hospitalized for acute heart failure

Women with acute heart failure have similar in-hospital mortality to men but are less treated in the real world, according to results from the global ALARM-HF registry presented today at the ESC Congress 2012. The findings were presented by Dr John T. Parissis from Greece.

27 Aug 2012

Power Over Pressure steering committee launches world's first hypertension online resource

The Power Over Pressure steering committee today announced the launch of the world's first online resource created to help healthcare professionals improve diagnosis and develop solutions for treatment-resistant hypertension, an urgent and growing public health issue that affects 120 million people worldwide.

23 Aug 2012

UC San Diego, iSAEC partner to study genetics of drug induced renal injury

The International Serious Adverse Events Consortium (iSAEC) announced today it will collaborate with the University of California, San Diego School of Medicine and UC San Diego Skaggs School of Pharmacy and Pharmaceutical Science to research the genetics of drug induced renal injury (DIRI).

22 Aug 2012

Study utilizes integrative approach to probe biology of bipolar disorder

The more that we understand the brain, the more complex it becomes. The same can be said about the genetics and neurobiology of psychiatric disorders. For "Mendelian" disorders, like Huntington disease, mutation of a single gene predictably produces a single clinical disorder, following relatively simple genetic principals. Compared to Mendelian disorders, understanding bipolar disorder has been extremely challenging. Its biology is not well understood and its genetics are complex.

21 Aug 2012

Study uncovers new pathway that can treat depression

Depression takes a substantial toll on brain health. Brain imaging and post-mortem studies provide evidence that the wealth of connections in the brain are reduced in individuals with depression, with the result of impaired functional connections between key brain centers involved in mood regulation. Glial cells are one of the cell types that appear to be particularly reduced when analyzing post-mortem brain tissue from people who had depression.

16 Aug 2012