Protein C News and Research

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The intranasal route of immunization may offer effective protection against SARS-CoV-2

Researchers at the School of Medicine, Washington University in Saint Louis, USA, showed that the intranasal route of immunization could provide a more efficient protection against SARS-CoV-2 compared to the intramuscular route (i.e. through ‘jabs’).

7 Dec 2020

Novel form of tau in spinal fluid indicates the stage of Alzheimer’s disease

A novel form of an Alzheimer's protein found in the fluid that surrounds the brain and spinal cord indicates what stage of the disease a person is in, and tracks with tangles of tau protein in the brain, according to a study from researchers at Washington University School of Medicine in St. Louis.

7 Dec 2020

Potential SARS-CoV-2 Mpro inhibitors identified by in silico screening

The search for effective inhibitors of SARS-CoV-2 is assuming new urgency as the fall/winter resurgence of the infection appears.

7 Dec 2020

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

The COVID-19 pandemic is showing a strong comeback after an initial reduction in the number of cases, following energetic public health interventions.

7 Dec 2020

COVID-19 genetic risk variants impact diverse immune cell types and severe disease manifestations

A team of researchers from UK and US used the DICE database and 3D cis-interactome maps to generate a list of target genes and immune cell types that are most affected by the genetic variants associated with COVID-19 severity.

7 Dec 2020

Study reveals genetic abnormalities that cause brain aneurysms

Nearly three percent of the world's population is at risk of developing an intracranial aneurysm, a localized dilation of a blood vessel forming a fragile pocket. Rupture of this aneurysm results in extremely severe, and, in one-third of cases, fatal hemorrhage.

7 Dec 2020

STE90-C11, a SARS-CoV-2 neutralizing antibody, shows high inhibition of RBD-ACE2 binding

In a new study, researchers describe the identification of a neutralizing antibody that binds to the RBD at the same site as the human host cell receptor.

7 Dec 2020

Molecular simulations reveal that remdesivir targets two SARS-CoV-2 enzymes

Remdesivir has been shown to target both RNA-dependent RNA polymerase and main protease of SARS-CoV-2 – resulting in a ‘double whammy’ effect.

7 Dec 2020

Evolution of the SARS-CoV-2 proteome in 3D during the first six months of the COVID-19 pandemic

In a recent study, researchers report how the SARS-CoV-2 proteome in 3D has evolved during the first six months of the COVID-19 pandemic.

7 Dec 2020

High-performance ELISA for serology in mild-moderate non-hospitalized COVID-19

A new study describes an ELISA assay that combines the detection of IgM, IgA, and IgG antibodies against the SARS−CoV−2 trimeric spike glycoprotein.

7 Dec 2020

Novel modular design approach to antibody nanocage generation

A new study shows the benefits of using computational design to create antibody nanocages that have the required orientation.

7 Dec 2020

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

A new study indicates that the topoisomerase 1 (Top1) is intimately related to the lethal inflammation associated with SARS-CoV-2 infection in a large proportion of cases.

7 Dec 2020

New biomarker of Alzheimer's may lead to enhanced diagnostic methods

Scientists at Washington University School of Medicine, Missouri, have identified a novel form of an Alzheimer’s protein in the spinal fluid of patients.

7 Dec 2020

Researchers identify new target that may lead to novel treatment for Alzheimer’s disease

Researchers at the Case Western Reserve University School of Medicine have identified a new target in development of Alzheimer's disease (AD) that could lead to therapies focused on treating the neurodegenerative condition early in its progression.

7 Dec 2020

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clinical investigators from Hackensack Meridian Health John Theurer Cancer Center (JTCC), a member of the Georgetown Lombardi Comprehensive Cancer Center consortium, are to present updates on treatment advances in multiple myeloma (MM), mantle cell lymphoma (MCL), and other types of B-cell lymphoma (BCL) as well as leukemia at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held virtually from December 5-8, 2020.

7 Dec 2020

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Imagine swabbing your nostrils, putting the swab in a device, and getting a read-out on your phone in 15 to 30 minutes that tells you if you are infected with the COVID-19 virus.

5 Dec 2020

Researchers develop wound-healing gel based on a substance produced by Trichoderma fungi

Researchers from the Department of Biochemistry of RUDN University developed a wound-healing gel based on a substance that is produced by Trichoderma fungi.

5 Dec 2020

Rice biochemist discovers hidden structure in essential metabolic machinery

In his first year of graduate school, Rice University biochemist Zachary Wright discovered something hidden inside a common piece of cellular machinery that's essential for all higher order life from yeast to humans.

5 Dec 2020

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease.

5 Dec 2020

Using gene therapy to achieve the positive health effects of physical exercise

Gene therapy is the most effective method to be able to provide health benefits you normally gain through physical exercise.

5 Dec 2020

Protein C News and Research

The intranasal route of immunization may offer effective protection against SARS-CoV-2

Novel form of tau in spinal fluid indicates the stage of Alzheimer’s disease

Potential SARS-CoV-2 Mpro inhibitors identified by in silico screening

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

COVID-19 genetic risk variants impact diverse immune cell types and severe disease manifestations

Study reveals genetic abnormalities that cause brain aneurysms

STE90-C11, a SARS-CoV-2 neutralizing antibody, shows high inhibition of RBD-ACE2 binding

Molecular simulations reveal that remdesivir targets two SARS-CoV-2 enzymes

Evolution of the SARS-CoV-2 proteome in 3D during the first six months of the COVID-19 pandemic

High-performance ELISA for serology in mild-moderate non-hospitalized COVID-19

Novel modular design approach to antibody nanocage generation

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

New biomarker of Alzheimer's may lead to enhanced diagnostic methods

Researchers identify new target that may lead to novel treatment for Alzheimer’s disease

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Researchers develop wound-healing gel based on a substance produced by Trichoderma fungi

Rice biochemist discovers hidden structure in essential metabolic machinery

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

Using gene therapy to achieve the positive health effects of physical exercise

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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