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Silence Therapeutics receives patent for RNA silencing method

Silence Therapeutics plc announces the issuance of United States patent 7,772,203, titled "Methods and Compositions for Controlling Efficacy of RNA Silencing," by the United States Patent and Trademark Office (USPTO). The issued patent generally claims methods of enhancing RNA silencing with a double stranded RNA interference (RNAi) agent. The patent's RNA silencing method claims include coverage for the administering of a pharmaceutical composition containing short interfering RNA (siRNA), micro RNA (miRNA), pre-miRNA or short hairpin (shRNA) molecules. Silence believes the proprietary structural modification techniques covered in this patent will play a key role in increasing the potential therapeutic efficacy of RNAi therapeutics.

11 Aug 2010

Dr. Hastings receives grant for Spinal Muscular Atrophy research

Michelle Hastings, PhD, Assistant Professor in the Department of Cell Biology and Anatomy, in the Chicago Medical School of Rosalind Franklin University of Medicine and Science, has been awarded a five-year $1.68 million grant from the National Institutes of Health to support her research aimed at investigating treatments for the fatal children's disease, Spinal Muscular Atrophy (SMA).

11 Aug 2010

Study finds hormone replacement therapy increases breast cancer risk

A new analysis of the California Teachers Study, which analyzed hormone replacement therapy use among 2,857 women for almost 10 years, underscores the need for personalized risk-benefit discussions before women begin hormone therapy."This is evidence that the story is complicated," said Tanmai Saxena, an M.D./Ph.D. student at the Keck School of Medicine at the University of Southern California. "The benefits of hormone therapy for relief of postmenopausal symptoms among women are clear, but the risks are more complicated than we had previously thought."

11 Aug 2010

Three-year efficacy data on STELARA for psoriasis presented at American Academy of Dermatology meeting

New study findings showed that a majority of patients with moderate to severe plaque psoriasis who had a previous response to STELARA® (ustekinumab) sustained a clinical response for up to three years with continued treatment regardless of their body weight. Investigators also presented findings from an integrated safety analysis that included data from one Phase 2 and three Phase 3 trials in which treatment with STELARA demonstrated a favorable benefit-risk profile for up to three years of treatment, consistent with previous analyses.

10 Aug 2010

Older Americans suffer from full-blown depression: Report

Maureen Duffy's memories of her grandmother are cloudy. Not because of time, but by a condition that cast a shadow over the woman Duffy had visited as a child.

10 Aug 2010

Computerized warning system alerts harmful drug orders for older hospital patients

Adverse drug events, such as dizziness or confusion occur in an estimated 40 percent of all hospital patients and can be the result of inappropriate medications being ordered. Not surprisingly, elderly individuals are particularly vulnerable to these adverse events, which not only result in longer hospitalizations, but can also pose a threat of serious complications and even death.

10 Aug 2010

Brain-wave pattern study may lead to techniques for enhancing sleep spindles

People who have trouble sleeping in noisy environments often resort to strategies like earplugs or noise-cancelling headphones that muffle the sound, but a new study from investigators at Massachusetts General Hospital (MGH) may lead to ways to block disturbing sounds within the brain. In their report in the August 10 issue of Current Biology, the team reports finding a brain-wave pattern, reflecting activity of a key structure, that predicts the ease at which sleep can be disrupted by noise.

10 Aug 2010

Scientific paper explains impact of visual cycle modulation in neurovascular retinopathy

Acucela, a clinical-stage biotechnology company focused on developing new treatments for blinding eye diseases, announced today that a scientific paper co-authored by Ryo Kubota, M.D., Ph.D., chairman, president and chief executive officer of Acucela, has been published in Experimental Eye Research. The paper, "Visual Cycle Modulation in Neurovascular Retinopathy" was also co-authored by scientists from Children's Hospital and Harvard Medical School in Boston and demonstrates for the first time the impact of treatment with a visual cycle modulator (VCM) on retinopathy in an immature eye.

10 Aug 2010

Study on ethnic disparities in pediatric asthma in Latino and non-Latino children

A new study by researchers at the Bradley Hasbro Children's Research Center and the University of Puerto Rico may help explain some of the well-documented ethnic disparities in pediatric asthma.

10 Aug 2010

Nat'l Health Services Corps spending more to increase primary care docs in underserved areas

The Washington Post reports on the Obama administration's efforts "to bring thousands of young primary care doctors to underserved areas … and keep them there. The administration recently invested more than $1 billion from the stimulus and the health-care law into the National Health Services Corps to beef up doctor recruitment.

10 Aug 2010

Ratios between males and females affect human longevity: Study

"Love stinks!" the J. Geils band told the world in 1980, and while you can certainly argue whether or not this tender and ineffable spirit of affection has a downside, working hard to find it does. It may even shorten your life.

10 Aug 2010

Sound sleepers show distinct pattern of spontaneous brain rhythms: Research

Ever wonder why some people can sleep through just about anything, while others get startled awake at each and every bump in the night? A new report in the August 10th issue of Current Biology, a Cell Press publication, offers some insight: sound sleepers show a distinct pattern of spontaneous brain rhythms.We found that by measuring brain waves during sleep, we could learn a lot about how well a person's brain can block the negative effects of sounds; the more sleep spindles your brain produces, the more likely you'll stay asleep, even when confronted with noise, said Jeffrey Ellenbogen of Harvard Medical School.

10 Aug 2010

Scientist to research on molecular machinery of breast cancer

Someone in the world is diagnosed with breast cancer every 23 seconds. It is the leading cause of cancer death worldwide among women and approximately 456,000 die from the disease each year. At The University of Texas Health Science Center at Houston (UTHealth), a scientist is taking aim at the molecular machinery behind this disease.

10 Aug 2010

Scientists work towards creating a vaccine for Parkinson's disease

Nina Brown, 68, and millions of others with a debilitating neurological condition called Parkinson's disease are counting on researchers for a cure. At The University of Texas Health Science Center at Houston (UTHealth), protein chemists are working to develop a therapeutic vaccine.

10 Aug 2010

Researchers recommends robotic prostatectomy over traditional open surgery method

While sharp debate continues among medical professionals as to whether a radical prostatectomy performed with the assistance of a robotic device is more beneficial than the traditional open surgery method, research just published by investigators at The Cancer Institute of New Jersey (CINJ) shows new evidence supporting the safety of the robotic procedure - including what is believed to be one of the lowest complication rates to date. CINJ is a Center of Excellence of UMDNJ-Robert Wood Johnson Medical School.

6 Aug 2010

Study identifies options for restoring knee cartilage lubrication to prevent OA

An injury to the anterior cruciate ligament is fairly common, especially among young athletes. While it can often be corrected through surgery, the injury can lead to increased risk of developing degenerative joint diseases, including osteoarthritis. The problem is that fluid in the knee joint, which lubricates the cartilage, is impacted by the trauma of the injury and begins to deteriorate.

6 Aug 2010

UCI School of Medicine's incoming students to receive iPad tablet computer as part of iMedEd Initiative

Traditionally, first-year medical students are awarded white coats to signify their entry into the medical community. But at an Aug. 6 ceremony, each member of the UC Irvine School of Medicine's incoming class of 2014 will find a surprise tucked into the coat's pocket: an iPad tablet computer pre-loaded with everything necessary for the first year of course work.

5 Aug 2010

Study finds proximal prayer may help another person's healing

Findings reported today from a new international study of healing prayer suggest that prayer for another person's healing just might help especially if the one praying is physically near the person being prayed for.Candy Gunther Brown, an associate professor in the Department of Religious Studies at Indiana University Bloomington, led the study of "proximal intercessory prayer" for healing. It is available online today and will be published in the September 2010 issue of the Southern Medical Journal.

5 Aug 2010

University of Pennsylvania announces recipients of 2010 Templeton Positive Neuroscience Awards

The Positive Psychology Center of the University of Pennsylvania and the John Templeton Foundation have announced the recipients of the 2010 Templeton Positive Neuroscience Awards, $2.9 million given to 15 new research projects at the intersection of neuroscience and positive psychology.

5 Aug 2010

Amputation can be prevented when patients are treated by podiatric physicians: Study

Amputation, one of the most devastating and costly consequences of diabetes, can be prevented when patients are treated by podiatric physicians. That's the finding of a national, large-scale study co-authored by Dr. James Wrobel, DPM, MS, Associate Professor of Medicine at Rosalind Franklin University of Medicine and Science.

5 Aug 2010

Medical School News and Research

Silence Therapeutics receives patent for RNA silencing method

Dr. Hastings receives grant for Spinal Muscular Atrophy research

Study finds hormone replacement therapy increases breast cancer risk

Three-year efficacy data on STELARA for psoriasis presented at American Academy of Dermatology meeting

Older Americans suffer from full-blown depression: Report

Computerized warning system alerts harmful drug orders for older hospital patients

Brain-wave pattern study may lead to techniques for enhancing sleep spindles

Scientific paper explains impact of visual cycle modulation in neurovascular retinopathy

Study on ethnic disparities in pediatric asthma in Latino and non-Latino children

Nat'l Health Services Corps spending more to increase primary care docs in underserved areas

Ratios between males and females affect human longevity: Study

Sound sleepers show distinct pattern of spontaneous brain rhythms: Research

Scientist to research on molecular machinery of breast cancer

Scientists work towards creating a vaccine for Parkinson's disease

Researchers recommends robotic prostatectomy over traditional open surgery method

Study identifies options for restoring knee cartilage lubrication to prevent OA

UCI School of Medicine's incoming students to receive iPad tablet computer as part of iMedEd Initiative

Study finds proximal prayer may help another person's healing

University of Pennsylvania announces recipients of 2010 Templeton Positive Neuroscience Awards

Amputation can be prevented when patients are treated by podiatric physicians: Study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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