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Inherited genes linked to toxicity of leukemia therapy

St. Jude investigators have discovered inherited variations in certain genes that make children with acute lymphoblastic leukemia (ALL) susceptible to the toxic side effects caused by chemotherapy medications.

23 Jun 2007

DNA repair by Brca2 prevents medulloblastoma

St. Jude investigators have gained some of the first major insights into how certain genes known to prevent cancer also guide the nervous system's normal development before birth and during infancy by repairing DNA damage.

23 Jun 2007

DNA repair proteins monitored at double-strand break

St. Jude investigators recently had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends.

23 Jun 2007

40 percent of parents willing to have their child's DNA stored in a government biobank

Genetic testing holds great promise for the future. Information generated by genetic testing may provide information that leads to new treatments for common diseases such as heart disease and diabetes.

23 Jun 2007

Estrogen use lowered one risk factor for heart disease among some younger postmenopausal women

A follow-up study to the federally funded Women's Health Initiative should help allay one concern in a subset of women in their 50s who are considering taking estrogen to relieve hot flashes.

23 Jun 2007

Smoking affects ligament healing

The list of reasons you shouldn't smoke has gotten longer. Researchers at Washington University School of Medicine in St. Louis are reporting that smoking interferes with ligament healing.

23 Jun 2007

Autism-related proteins control nerve excitability

Two proteins that are implicated in autism have been found to control the strength and balance of nerve-cell connections, researchers at UT Southwestern Medical Center have found.

23 Jun 2007

Gay pride events offer opportunity to identify new HIV cases among MSM

Gay pride events provide opportunities outside of health care settings to identify new HIV cases among men who have sex with men, particularly among MSM in racial and ethnic minorities, according to a study published in the June 22 edition of CDC's Morbidity and Mortality Weekly Report, Reuters Health reports (Reuters Health, 6/21).

22 Jun 2007

Children as young as 11 use drugs to win at sport

According to French researchers athletes as young as eleven admit to using drugs to enhance their sporting performance.

21 Jun 2007

Obesity and wrist shape correlate with a higher prevalence of carpal tunnel syndrome

Weight loss in obese patients, however, does not bring relief of the syndrome. Experts suggest a genetic link between the two conditions, or a genetic profile that pre-disposes a patient to both conditions.

20 Jun 2007

New online guide to complementary and alternative cancer treatments

People with cancer now have a direct route to complementary and alternative treatments worldwide, thanks to a new online directory from UK charity Yes to Life.

20 Jun 2007

Rheumatoid factor is a risk factor for heart disease in men

Scientists have found that a product of white blood cells linked to rheumatoid arthritis could cause heart disease in men.

20 Jun 2007

Gene test not needed if cancer drug irinotecan given in low dose

Investigators at St. Jude Children's Research Hospital have shown that when the cancer drug irinotecan is given in low doses for multiple days, it eliminates the need to delay treatment to perform costly genetic testing that determines if the patient is at risk for serious treatment side effects, such as neutropenia.

20 Jun 2007

Many kids using performance enhancing drugs in sport

More than one per cent of eleven year olds admit using performance enhancing drugs to do better in sports reports a study published online ahead of print in the British Journal of Sports Medicine.

20 Jun 2007

Two complementary commanders in charge of the brain

A probe of the upper echelons of the human brain's chain-of-command has found strong evidence that there are not one but two complementary commanders in charge of the brain, according to neuroscientists at Washington University School of Medicine in St. Louis.

20 Jun 2007