Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

Study reveals mechanisms by which SGLT2 inhibitors produce renoprotective effect

SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli.

8 Jun 2021

Distinct spike protein mutations in SARS-CoV-2 variant in Russia

Additionally, a novel variant has recently been characterized by researchers from Russia in the journal Viruses. The variant, first discovered in January 2021 in Northwest Russia, is characterized by distinct spike protein mutations.

7 Jun 2021

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a rare form of kidney inflammation (glomerulonephritis) in which the glomeruli become increasingly scarred (sclerotic), leading to progressive loss of kidney function.

7 Jun 2021

Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

The Italian authors of this paper, published in the journal Viruses, have taken this hypothesis and expanded it to include viral particles suspended in the air or on inanimate objects as a possible source of T cell immunity due to the repeated low-dose exposure, potentially explaining virus immunity found in non-infected individuals.

7 Jun 2021

Study observes broad and invariable memory B cell response following SARS-CoV-2 infection

A new study by researchers at the Oregon Health & Science University (OHSU) in the USA goes far in answering this question by showing the presence of memory B cells that react to the original SARS-CoV-2 as well as VOCs.

7 Jun 2021

Researchers identify a bacterium with anti-SARS-CoV-2 activity in vitro: Dolosigranulum pigrum

As intensive efforts are on to counter the virus, a new study by an international team of researchers reports the unexpected success of a bacterium in modulating the immune response in the airway and protecting the cells against infection with this virus.

7 Jun 2021

Could sustained inflammation following mild to moderate COVID-19 be a driver of long COVID?

A new study describes the discovery of sustained though low-level rises in inflammatory mediators and immune cells, as well as the loss of some subsets of naïve un-activated cells. This may indicate a widespread though muted immune-mediated inflammatory response in these patients.

7 Jun 2021

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

An interesting new bioRxiv* preprint reports the suppression of monocyte glycolysis and cytokine production when exposed to the virus, following pretreatment with the commonly used drug, metformin.

6 Jun 2021

Risk of SARS-CoV-2 spread to bats

A recent bioRxiv* preprint offers a powerful risk assessment approach to estimate the risk of bat exposure to SARS-CoV-2 from humans during their interactions in the wild.

4 Jun 2021

SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

In a new study by researchers in the UK, Germany and South Africa, this process is visualized using time-lapse microscopy of a human cell lung line, demonstrating that SARS-CoV-2 can induce cell-to-cell fusion within 6 hours post-infection. Further, the application of neutralizing monoclonal antibodies or convalescent plasma was unable to prevent the spread of the virus by this mechanism, suggesting that removing SARS-CoV-2 from cells permissive of cell membrane fusion could be more difficult than other types of cell.

4 Jun 2021

Novel insights can open doors to combating clotting-related problems in COVID-19

Researchers scour what is known to come up with a hypothesis of why blood clots can be a major problem in COVID-19

4 Jun 2021

Study brings to light the role of a cellular protein in COVID-19 infections

Angiotensin-converting enzyme 2 (ACE2), a protein found on the surface of lung cells, facilitates the entry of the novel coronavirus into host cells.

4 Jun 2021

Two repurposed drugs inhibit SARS-CoV-2 entry factors in a synergistic manner

A preprint paper uploaded to the bioRxiv* server shows how combining drugs targeting different entry factors of the host cell may prevent infection by the virus.

3 Jun 2021

Mast cell activation may underlie inflammation in severe COVID-19

A new preprint research paper posted to the medRxiv* server points to mast cells as major culprits in the etiology of severe and critical COVID-19. This could suggest suitable therapeutic and preventive interventions to reduce the morbidity and mortality of this viral illness.

3 Jun 2021

Could a green tea compound combat SARS-CoV-2?

Researchers recently published an article that reviewed the mechanisms by which EGCG could inhibit SARS-CoV-2 infection and the various syndromes caused by COVID-19.

3 Jun 2021

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

New research undertaken by researchers in the USA describes two parallel but distinct in vivo approaches for the accelerated discovery of antibodies targeting SARS-CoV-2 spike protein.

3 Jun 2021

Long COVID patients at higher risk of small airway disease

The preprint discussed herein describes the effects of SARS-CoV-2 on lung structure and function in patients with long COVID.

2 Jun 2021

Novel SARS-CoV-2 variants partially resistant to infection- and vaccine-induced immunity, study finds

A recent study conducted by a team of scientists in the Netherlands has revealed that while severely affected hospitalized COVID-19 patients and vaccinated individuals are capable of neutralizing the B.1.1.7, B.1.351, and P.1 variants of SARS-CoV-2, a significant proportion of non-hospitalized patients with less severe COVID-19 remain susceptible to these viral variants.

2 Jun 2021

Could semen quality indicate SARS-CoV-2 insult susceptibility in polluted areas?

In a recent review in Environmental Science and Pollution Research, Italian researchers focused on “the evidence that correlates the degree and type of pollution with the increased susceptibility of many countries to this pandemic and proposes human semen as an early marker of the environmental health and the general health of individuals.” Their observations are based on a robust body of experimental evidence.

2 Jun 2021

New vaccine candidate with RBD and N protein targets protects against SARS-CoV-2 in preclinical trials

A recent study published in the journal Science Advances, explores the immunization of RBD with the P2 epitope of tetanus toxoid, to enhance its immunogenicity, and also tests the benefit of N protein in the vaccine.

2 Jun 2021

Angiotensin News and Research

Further Reading

Study reveals mechanisms by which SGLT2 inhibitors produce renoprotective effect

Distinct spike protein mutations in SARS-CoV-2 variant in Russia

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

Study observes broad and invariable memory B cell response following SARS-CoV-2 infection

Researchers identify a bacterium with anti-SARS-CoV-2 activity in vitro: Dolosigranulum pigrum

Could sustained inflammation following mild to moderate COVID-19 be a driver of long COVID?

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

Risk of SARS-CoV-2 spread to bats

SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

Novel insights can open doors to combating clotting-related problems in COVID-19

Study brings to light the role of a cellular protein in COVID-19 infections

Two repurposed drugs inhibit SARS-CoV-2 entry factors in a synergistic manner

Mast cell activation may underlie inflammation in severe COVID-19

Could a green tea compound combat SARS-CoV-2?

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

Long COVID patients at higher risk of small airway disease

Novel SARS-CoV-2 variants partially resistant to infection- and vaccine-induced immunity, study finds

Could semen quality indicate SARS-CoV-2 insult susceptibility in polluted areas?

New vaccine candidate with RBD and N protein targets protects against SARS-CoV-2 in preclinical trials

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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