Cell Nucleus News and Research

RSS

Scientists reveal how TREX proteins act as passport for transfer of cell blueprints

Decoded process could hold the key to future treatments for a wide range of chronic health problems including Motor Neuron Disease, myotonic dystrophy and a wide range of cancers, University of Sheffield scientists have revealed.

16 Aug 2012

U of U researchers receive NIH grant to study cellular and molecular causes of blood clots

University of Utah Department of Medicine researchers have received $16 million from the National Institutes of Health (NIH) to set up a translational research center to study the cellular and molecular causes of blood clots, a serious threat to millions of people who have diabetes, are obese or have other metabolic disorders.

15 Aug 2012

Gadd45a protein plays a key role in skeletal muscle atrophy

Whether you're old, have been ill, or suffered an injury, you've watched gloomily as your muscles have atrophied. The deterioration of muscle-even slight or gradual-is about as common to the human condition as breathing.

14 Aug 2012

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes.

8 Aug 2012

Researchers identify how telomerase is recruited to chromosome ends

Stem cells are special. Nestled in muscle and skin, organ and bone, they bide their time over years or decades until called to replace damaged or lost tissue. One secret to their longevity is an enzyme called telomerase, which stills the relentless ticking of the molecular clock that limits the life span of other cells.

3 Aug 2012

Anacardic acid can rescue some ALS phenotypes in vitro

A research group at the Center for iPS Cell Research and Application (CiRA) at Japan's Kyoto University has successfully recapitulated amyotrophic lateral sclerosis (ALS)-associated abnormalities in motor neurons differentiated from induced pluripotent stem cells (iPSCs) obtained from patients with familial ALS, a late-onset, fatal disorder which is also known for Lou Gehrig's disease. In a drug screening assay using the disease model, the team further found that the chemical compound anacardic acid can rescue some ALS phenotypes in vitro.

3 Aug 2012

Possible molecular link between circadian rhythm disturbances and increased inflammatory response

Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic inflammatory diseases such as diabetes, obesity and cancer.

2 Aug 2012

Scientists identify biological mechanism that may be responsible for icy extremities

Cold feet-those chilly appendages that plague many people in the winter and an unlucky few all year round-can be the bane of existence for singles and couples alike. In a new study, scientists led by Selvi C. Jeyaraj of the Research Institute at Nationwide Children's Hospital have identified a biological mechanism that may be responsible for icy extremities: an interaction between a series of molecules and receptors on smooth muscle cells that line the skin's tiny blood vessels.

1 Aug 2012

New research indicates molecular signaling from end to end in peripheral nerve cells

When the longest cells in the body are injured at their farthest reaches, coordinating the cells' repair is no easy task. This is in part because these peripheral nerve cells can be extremely long - up to one meter in adult humans - which is a lot of distance for a molecular distress signal to cover in order to reach the "command center" of the cell's nucleus.

30 Jul 2012

Researchers use neuroimaging to study brains of preschool children with ADHD symptoms

Young children often have problems paying attention or concentrating, but when are these problems serious enough for parents and teachers to be concerned? According to estimates from the Centers for Disease Control, 1 in 11 school-aged children are diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD), but research suggests that the warning signs often appear even before the demands of school begin.

28 Jul 2012

Study validates importin beta1 protein's crucial role in nerve repair

Several years ago, Prof. Michael Fainzilber and his group in the Biological Chemistry Department made a surprising discovery: Proteins thought to exist only near the cell nucleus could also be found in the far-off regions of the body's longest cells - peripheral nerve cells that extend processes called axons, reaching up to a meter in length in adult humans.

27 Jul 2012

Karyopharm commences two KPT-330 phase 1 studies in cancers

Karyopharm Therapeutics Inc., a leader in the new field of nuclear transport modulators, announced dosing of patients in the first-in-human clinical trials with KPT-330.

25 Jul 2012

Overeating and increased weight linked to brain region associated with motivation and reward

Snack consumption and BMI are linked to both brain activity and self-control, new research has found.

23 Jul 2012

Protein associated with Huntington’s and other neurodegenerative diseases has several brain-specific forms

A protein essential for metabolism and recently associated with neurodegenerative diseases also occurs in several brain-specific forms. This discovery emerged in the course of a research project funded by the Austrian Science Fund FWF, the findings of which have now been published in the journal Human Molecular Genetics.

23 Jul 2012

Test for motile sperm improves ICSI outcomes

Researchers have developed a new sperm test that could improve pregnancy rates among women treated with intracytoplasmic sperm injection.

23 Jul 2012

DBS achieves stable motor improvements in Parkinson’s

Deep brain stimulation for patients with Parkinson’s disease achieves improvements in motor symptoms that are sustained over 3 years, report researchers.

19 Jul 2012

New research sheds light on pluripotency

New research at the Hebrew University of Jerusalem sheds light on pluripotency-the ability of embryonic stem cells to renew themselves indefinitely and to differentiate into all types of mature cells.

19 Jul 2012

Helmholtz-Zentrum Geesthacht to establish Virtual Institute

In collaboration with the university hospitals of Hamburg, Hannover and Graz, as well as further partners, the Helmholtz-Zentrum Geesthacht will establish a Virtual Institute, whose focus will be set on degradable magnesium implants. One aim of the research association coordinated from Geesthacht is to develop first prototypes of orthopedic implants.

19 Jul 2012

Cadherin-catenin-actin structure exerts force inside and between cells in living tissues

If you place certain types of living cells on a microscope slide, the cells will inch across the glass, find their neighbors, and assemble themselves into a simple, if primitive tissue. A new study at Stanford University may help explain this phenomenon, and then some, about the mechanical structure and behavior of complex living organisms.

17 Jul 2012

Novel molecular mechanism responsible for most important symptom of major depression

Stanford University School of Medicine scientists have laid bare a novel molecular mechanism responsible for the most important symptom of major depression: anhedonia, the loss of the ability to experience pleasure.

12 Jul 2012

Cell Nucleus News and Research

Scientists reveal how TREX proteins act as passport for transfer of cell blueprints

U of U researchers receive NIH grant to study cellular and molecular causes of blood clots

Gadd45a protein plays a key role in skeletal muscle atrophy

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

Researchers identify how telomerase is recruited to chromosome ends

Anacardic acid can rescue some ALS phenotypes in vitro

Possible molecular link between circadian rhythm disturbances and increased inflammatory response

Scientists identify biological mechanism that may be responsible for icy extremities

New research indicates molecular signaling from end to end in peripheral nerve cells

Researchers use neuroimaging to study brains of preschool children with ADHD symptoms

Study validates importin beta1 protein's crucial role in nerve repair

Karyopharm commences two KPT-330 phase 1 studies in cancers

Overeating and increased weight linked to brain region associated with motivation and reward

Protein associated with Huntington’s and other neurodegenerative diseases has several brain-specific forms

Test for motile sperm improves ICSI outcomes

DBS achieves stable motor improvements in Parkinson’s

New research sheds light on pluripotency

Helmholtz-Zentrum Geesthacht to establish Virtual Institute

Cadherin-catenin-actin structure exerts force inside and between cells in living tissues

Novel molecular mechanism responsible for most important symptom of major depression

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News