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New approach could lead to quicker generation of effective, personalized cancer vaccines

Scientists have created a pipeline for identifying, prioritizing and evaluating potential tumor antigens for the fast generation of cancer vaccines, according to a report published today in eLife.

22 Mar 2022

Intranasal delivery of pro-resolving lipid mediators arrests memory loss in experimental Alzheimer’s model

A research collaboration between scientists at LSU Health New Orleans and the Karolinska Institutet in Sweden has found that applying specialized pro-resolving lipid mediators intranasally arrested memory loss and brain degeneration in an experimental model of Alzheimer's Disease (AD).

21 Mar 2022

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

The immune system deteriorates with age, making COVID-19 particularly deadly in older people - but to date, no clinically available medication addresses this key risk factor.

21 Mar 2022

Researchers find effective nutritional strategies to prevent acute kidney injury

A research team led by Professor Dr Roman-Ulrich Müller has established that four out of six different nutritional strategies prevent acute kidney injury in the mouse model.

21 Mar 2022

Study: Targeting astrocytes reduces tau-related brain damage and inflammation in mice

Alzheimer's disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau.

18 Mar 2022

Researchers find turbocharger for memory in the brain cells of mice

Scientists have long known that learning requires the flow of calcium into and out of brain cells. But researchers at Columbia's Zuckerman Institute have now discovered that floods of calcium originating from within neurons can also boost learning.

17 Mar 2022

Excessive neuropeptide secretion in the lungs can lead to fluid buildup and poor oxygenation

COVID-19 has put a spotlight on the pulmonary and nervous systems, but there is still much to learn about how they interact. Researchers at University of California San Diego School of Medicine recently explored this relationship in the context of a childhood lung disease, but their findings may also apply to COVID-19 symptoms.

17 Mar 2022

Novel metabolic mechanisms contribute to how ovarian cancer evades immune attack, research finds

High-grade serous carcinoma is the most aggressive form of ovarian cancer and accounts for the majority of advanced-stage cases.

16 Mar 2022

Researchers receive grant to find answers to taste loss in COVID patients

Up to 80% of individuals who've had COVID-19 report temporary or lasting changes in their sense of taste, and scientists are working to better understand the biological basis of why, including whether our taste buds are a direct virus target.

15 Mar 2022

Study explores neutralization of SARS-CoV-2 Omicron variant by subunit vaccine boosters

A new study assessed the neutralization induced by subunit vaccine boosters specific for the SARS-CoV-2 Omicron variant of concern.

14 Mar 2022

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

New research describes a novel approach whereby SARS-2 antigens were analyzed for conserved sites that may be targeted by broadly neutralizing antibodies that will confer immunity to other Sarbecoviruses.

10 Mar 2022

A promising approach for COVID-19 prophylaxis

SARS-CoV-2 viruses can hide from recognition by the immune system. However, the antiviral immune receptor RIG-I can be stimulated, which improves protection against lethal SARS-CoV-2 infections.

8 Mar 2022

New treatment strategy makes pancreatic tumors sensitive to immunotherapy, mice study shows

Pancreatic cancer is one of the most aggressive and deadly tumor types and notorious for its resistance to virtually all types of treatment, including newer immunotherapies.

7 Mar 2022

Combating COVID cytokine storm with targeted nucleic acid therapies

Researchers examine current nucleic acid-based treatments against COVID-19 and their methods of action.

6 Mar 2022

Novel drug candidate protects lab mice against cognitive decline by reducing brain inflammation

An anti-inflammatory drug candidate, known as 3,6'-dithiopomalidomide (DP), designed by researchers at the National Institute on Aging, protected lab mice against cognitive decline by reducing brain inflammation.

2 Mar 2022

Intestinal cells can change specializations during their lives, finds study

Intestinal cells can change specializations during their lives. The BMP signaling pathway – an important communication mechanism between cells – appears to be the driver of these changes.

1 Mar 2022

Scientists discover an innate form of immunological memory in the intestine

The innate immune system plays a crucial role in regulating host-microbe interactions, and especially in providing protection against pathogens that invade the mucosa.

28 Feb 2022

Researchers demonstrate the powerful gene silencing effects of HDO technology

T and B lymphocytes, which are part of a group of immune cells commonly called white blood cells, work together to eliminate foreign invaders in the body such as viruses.

28 Feb 2022

MUSC study sheds light on better ways to prevent and treat colorectal cancer

An MUSC Hollings Cancer Center study sheds light on better ways to prevent and treat colorectal cancer, which often is found at advanced stages when it's much harder to treat.

28 Feb 2022

Study examines the effect of sevoflurane on sleep disturbance caused by systemic inflammation

Getting a good night's sleep can sometimes be a challenge, but inflammation may make it even more difficult.

24 Feb 2022

Mouse Model News and Research

New approach could lead to quicker generation of effective, personalized cancer vaccines

Intranasal delivery of pro-resolving lipid mediators arrests memory loss in experimental Alzheimer’s model

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

Researchers find effective nutritional strategies to prevent acute kidney injury

Study: Targeting astrocytes reduces tau-related brain damage and inflammation in mice

Researchers find turbocharger for memory in the brain cells of mice

Excessive neuropeptide secretion in the lungs can lead to fluid buildup and poor oxygenation

Novel metabolic mechanisms contribute to how ovarian cancer evades immune attack, research finds

Researchers receive grant to find answers to taste loss in COVID patients

Study explores neutralization of SARS-CoV-2 Omicron variant by subunit vaccine boosters

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

A promising approach for COVID-19 prophylaxis

New treatment strategy makes pancreatic tumors sensitive to immunotherapy, mice study shows

Combating COVID cytokine storm with targeted nucleic acid therapies

Novel drug candidate protects lab mice against cognitive decline by reducing brain inflammation

Intestinal cells can change specializations during their lives, finds study

Scientists discover an innate form of immunological memory in the intestine

Researchers demonstrate the powerful gene silencing effects of HDO technology

MUSC study sheds light on better ways to prevent and treat colorectal cancer

Study examines the effect of sevoflurane on sleep disturbance caused by systemic inflammation

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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