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Researchers uncover novel pathogenic mechanism in Huntington’s disease

Researchers from the Institute of Neurosciences of the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute described a mechanism, the increase of proteinaceous synthesis, which takes part in the degeneration of the type of neurons that are affected in Huntington's disease, a genetic neurodegenerative disease.

20 Nov 2019

Newly developed ChiTaRS database can collect cases of druggable fusion targets

When sections from two separate genes merge due to various factors, such as translocation or splicing, the hybrid that is formed is called a gene fusion. In recent years, it has been discovered that these fusion events play a vital role in the development of cancers and other complex diseases.

20 Nov 2019

Fosun Pharma, MimiVax to jointly develop and commercialize SurVaxM therapy in U.S.

The inventors of a new and unique cancer immunotherapy developed at Roswell Park Comprehensive Cancer Center have announced a major step forward with that therapy, known as SurVaxM. MimiVax LLC principals Robert Fenstermaker, MD, and Michael Ciesielski, PhD, have announced that the company, spun off from Roswell Park in 2012, has entered into a China-exclusive licensing agreement for SurVaxM with Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd., a wholly-owned subsidiary of Shanghai Fosun Pharmaceutical Co. Ltd. based in Shanghai, China.

20 Nov 2019

Study highlights importance of parents in defining eating disorder recovery

Three in four patients with anorexia nervosa -- including many with challenging illness -- make a partial recovery. But just 21 percent make a full recovery, a milestone that is most likely to signal permanent remission.

20 Nov 2019

Breakthrough therapy could improve health and survival in people with cystic fibrosis

Researchers at the Children's Hospital Colorado Breathing Institute, one of the largest cystic fibrosis clinical care centers in the U.S., are part of a Therapeutics Development Network that oversaw clinical trials leading to FDA approval of TRIKAFTA, a new, highly-effective CF treatment for people with CF 12 years of age and older.

20 Nov 2019

Pioneering CRISPR therapy leaves two patients free of blood disease symptoms

The first two clinical trials for CRISPR-based treatments for inherited blood disorders have been successful.

20 Nov 2019

Circular DNA found in cancer cells supports their survival and resistance

A new study uncovers the role of the circular, 3D shape of extrachromosomal DNA in augmenting mutant oncogenes in cancer cells.

20 Nov 2019

Applying a Proteomics-based Approach to the Clinic

Matthias Mann explains why applying proteomics-based technologies such as timsTOF could accelerate the diagnosis and prediction of human disease.

From Bruker Daltonics 20 Nov 2019

American Association of Endodontists provides endodontic treatments to patients in Boston area

Yesterday, the American Association of Endodontists (AAE) provided more than 50 endodontic treatments (namely root canals) to patients in need in the Boston area.

20 Nov 2019

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

Subpopulations of tumor cells may exhibit diverging behaviors from the bulk tumor due to an alternate stress response that diverts tumor cells from apoptotic death.

20 Nov 2019

PCORI Board approves $70 million to support projects designed to improve care for health conditions

The Patient-Centered Outcomes Research Institute Board of Governors today approved $70 million to fund 21 studies and related projects designed to improve care for health conditions that impose high burdens on patients, their families and the healthcare system.

19 Nov 2019

Cell factors decide if a cancer grows or dies, says new study

A new study published today in the journal Cell Reports by scientists at the German Cancer Research Center (DKFZ) shows that the direction taken by a cancer cell depends on the configuration of the cell itself as well as the activation of a universal cancer cell receptor called CD95.

19 Nov 2019

Dopamine may worsen lung inflammation in asthma

A new study on a mouse model of asthma shows that nerve cells producing dopamine, a neurotransmitter, signal T cells in the body to promote inflammation due to allergic reactions in the lungs during childhood but not in adult mice.

19 Nov 2019

Researchers lay foundation for reliable blood clotting molecule models

Blood clots have long been implicated in heart attacks and strokes, together accounting for almost half of deaths annually in the United States.

19 Nov 2019

MIT researchers develop method to isolate T cells primed for certain allergies or infections

When your immune system is exposed to a vaccine, an allergen, or an infectious microbe, subsets of T cells that can recognize a foreign intruder leap into action.

19 Nov 2019

UC Davis study identifies mechanism to rapidly repair leaky gut in monkeys with SIV infections

A UC Davis study found that the damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus, was rapidly repaired within five hours of receiving Lactobacillus plantarum bacteria.

19 Nov 2019

Mysterious feather duvet lung disease nearly kills a man

A soft pillow and a warm duvet are all you need to have a soothing and relaxing sleep, especially during the frigid season. However, a man from the United Kingdom nearly died because of a mysterious illness related to a duvet. It was later found out by doctors that the culprit for his lung disease is his newly-bought feather duvet.

19 Nov 2019

VUMC offers minimally invasive, non-surgical alternative for patients with emphysema

Vanderbilt University Medical Center will be the first in the state to offer a minimally invasive, non-surgical alternative for patients with emphysema.

19 Nov 2019

Mayo Clinic, Hitachi to build North America's first carbon ion treatment facility

Mayo Clinic and Hitachi, Ltd. have reached an agreement in principle to build a carbon ion treatment facility as part of Mayo Clinic's recently announced integrated oncology facility which will be constructed at Mayo Clinic's campus in Jacksonville, Florida.

19 Nov 2019

Ammonia levels do not guide clinical management of hepatic encephalopathy in cirrhotic patients

The liver performs several critical functions including filtering blood, detoxifying chemicals and metabolizing drugs.

19 Nov 2019

Therapy News and Research

Researchers uncover novel pathogenic mechanism in Huntington’s disease

Newly developed ChiTaRS database can collect cases of druggable fusion targets

Fosun Pharma, MimiVax to jointly develop and commercialize SurVaxM therapy in U.S.

Study highlights importance of parents in defining eating disorder recovery

Breakthrough therapy could improve health and survival in people with cystic fibrosis

Pioneering CRISPR therapy leaves two patients free of blood disease symptoms

Circular DNA found in cancer cells supports their survival and resistance

Applying a Proteomics-based Approach to the Clinic

American Association of Endodontists provides endodontic treatments to patients in Boston area

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

PCORI Board approves $70 million to support projects designed to improve care for health conditions

Cell factors decide if a cancer grows or dies, says new study

Dopamine may worsen lung inflammation in asthma

Researchers lay foundation for reliable blood clotting molecule models

MIT researchers develop method to isolate T cells primed for certain allergies or infections

UC Davis study identifies mechanism to rapidly repair leaky gut in monkeys with SIV infections

Mysterious feather duvet lung disease nearly kills a man

VUMC offers minimally invasive, non-surgical alternative for patients with emphysema

Mayo Clinic, Hitachi to build North America's first carbon ion treatment facility

Ammonia levels do not guide clinical management of hepatic encephalopathy in cirrhotic patients

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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