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Experimental Therapeutics, Debiopharm join to develop oral small molecules targeting new class of epigenetic modulators

The Agency for Science, Technology and Research (A*STAR)'s Experimental Therapeutics Centre (ETC), a center of excellence to advance and accelerate drug discovery in Singapore, and Debiopharm Group™ (Debiopharm), the Swiss-based global biopharmaceutical company that focuses on the development of prescription drugs that target unmet medical needs including oncology as well as companion diagnostics, today announced the signature of an exclusive research collaboration to develop oral small molecules targeting new class of epigenetic modulators.

7 Oct 2013

Findings may result in better management of chronic depression

Virginia Commonwealth University has received a $3 million grant from the National Institute of Mental Health to study key molecular markers found in DNA that predict chronic depression.

2 Oct 2013

Laboratory testing kit that estimates risk of breast cancer relapse gets FDA approval

A laboratory testing kit that estimates the risk of breast cancer relapse in spite of anti-hormone treatment has received approval from the U.S. Food and Drug Administration.

2 Oct 2013

Genetic study helps identify obese diabetes patients who are at risk of developing NAFLD

A groundbreaking study of nearly 2,300 extremely obese diabetes patients, led by the Translational Genomics Research Institute, has identified genes associated with unhealthy liver function.

2 Oct 2013

Standoff between a mutated gene and normal counterpart keeps certain cancer cells alive

What keeps leukemia cells alive almost forever, able to continue dividing endlessly and aggressively? New research at the Weizmann Institute suggests that, in around a quarter of all leukemias, the cancer cells rely on an internal "balance of terror" to keep going.

1 Oct 2013

Four Geisinger Health System researchers receive $25M grant to initiate ClinGen Project

Four Geisinger Health System researchers have taken center stage in the national arena of genomics thanks to new funding from the National Human Genome Research Institute (NHGRI), an arm of the U.S. National Institutes of Health (NIH).

27 Sep 2013

Rhythm starts RM-493 clinical trials in obesity patients with genetic deficiency

Rhythm announced today the initiation of the first of a series of clinical trials with RM-493, the company's novel melanocortin 4 receptor (MC4R) agonist, for the treatment of obesity in individuals with a genetic deficiency in the MC4R pathway.

24 Sep 2013

Ventana, Boehringer Ingelheim to develop companion diagnostic tests for oncology programs

Ventana Medical Systems, Inc., a member of the Roche Group, and Boehringer Ingelheim announced today that they have entered into an agreement to collaborate on the development of companion diagnostic tests for Boehringer Ingelheim oncology programs.

19 Sep 2013

Gentris expands genomic biomarker offering with launch of Affymetrix GeneChip HTA services

Gentris Corporation, a global leader in pharmacogenomics and biorepository solutions, announced today that it is expanding its genomic biomarker offering with the launch of Affymetrix GeneChip Human Transcriptome Array services.

17 Sep 2013

Studying Tumor Mutations Via A Network Approach

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16 Sep 2013

New approach subtypes cancers by shared genetic effects; a step toward personalized medicine

Cancer tumors almost never share the exact same genetic mutations, a fact that has confounded scientific efforts to better categorize cancer types and develop more targeted, effective treatments.

16 Sep 2013

Data can help scientists, physicians match precision drugs to cancer's genetic traits

More than 5,000 genetic profiles of tumor DNA have been completed in a large research study by scientists at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Boston Children's Hospital designed to speed the development of personalized cancer care with precision treatments.

13 Sep 2013

NIH budget slashing may stall future pain research funding

Multi-faceted pain research discoveries within the last decade are bringing new hope for the estimated 100 million Americans with chronic pain. Unfortunately, translation of these scientific advances into clinical practice could be stalled without sufficient funding for both basic science and clinical pain research, according to the American Pain Society.

12 Sep 2013

Current criteria for ALK positive lung cancer needs to be redefined

A University of Colorado Cancer Center study published today in the journal Cancer shows that the current criteria used to match lung cancers with the drug crizotinib may miss some patients who could benefit from the drug. The findings suggest that doctors should look closer at borderline or atypical ALK-negative cases, and could widen the population of lung cancer patients offered treatment with crizotinib or other ALK-inhibitor drugs.

12 Sep 2013

Mount Sinai physician-scientists join DILIN to help find causes, diagnostics for drug-induced liver injury

In an effort to better understand and develop prevention strategies for drug-induced liver injury, physician-scientists from the Icahn School of Medicine at Mount Sinai have joined the Drug-Induced Liver Injury Network, a National Institutes of Health-funded consortium of only six academic medical centers in the United States.

12 Sep 2013

Bayer, Broad On Five-Year Mission To Search For Novel Cancer Therapeutics

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10 Sep 2013

Banook Central Imaging, Oncodesign partner to expand use of new approaches in pharmaco-imaging

Oncodesign, a contract research laboratory dedicated to the discovery of new anticancer therapies, and Banook Central Imaging, a company specializing in the centralized reading of medical images, today announce the start of a partnership to expand the use of new approaches in pharmaco-imaging.

10 Sep 2013

Viewpoints: Administration is 'fighting back' on Obamacare; Democrats' 'nervous breakdown' about GOP inquiry on navigators

In Washington, Republican members of the House Committee on Energy and Commerce have sent intimidating letters to many of the groups hired as navigators, demanding all their paperwork and suggesting that the groups intend to exploit the work for fund-raising or political purposes.

7 Sep 2013

Bioinformatics researchers investigate functional diversity of proteins

No two human beings are the same. Although we all possess the same genes, our genetic code varies in many places. And since genes provide the blueprint for all proteins, these variants usually result in numerous differences in protein function. But what impact does this diversity have? Bioinformatics researchers at Rutgers University and the Technische Universitaet Muenchen have investigated how protein function is affected by changes at the DNA level.

6 Sep 2013

Scientists identify enzyme mutation that occurs in castration-resistant prostate cancer

The mutation occurs in the androgen-synthesizing enzyme 3βHSD1 in castration-resistant prostate cancer (CRPC), according to research published online today in Cell. This mutation enables the tumor to make its own supply of androgens, a hormone that fuels the growth of the prostate cancer.

30 Aug 2013

Personalized Medicine News and Research

Experimental Therapeutics, Debiopharm join to develop oral small molecules targeting new class of epigenetic modulators

Findings may result in better management of chronic depression

Laboratory testing kit that estimates risk of breast cancer relapse gets FDA approval

Genetic study helps identify obese diabetes patients who are at risk of developing NAFLD

Standoff between a mutated gene and normal counterpart keeps certain cancer cells alive

Four Geisinger Health System researchers receive $25M grant to initiate ClinGen Project

Rhythm starts RM-493 clinical trials in obesity patients with genetic deficiency

Ventana, Boehringer Ingelheim to develop companion diagnostic tests for oncology programs

Gentris expands genomic biomarker offering with launch of Affymetrix GeneChip HTA services

Studying Tumor Mutations Via A Network Approach

New approach subtypes cancers by shared genetic effects; a step toward personalized medicine

Data can help scientists, physicians match precision drugs to cancer's genetic traits

NIH budget slashing may stall future pain research funding

Current criteria for ALK positive lung cancer needs to be redefined

Mount Sinai physician-scientists join DILIN to help find causes, diagnostics for drug-induced liver injury

Bayer, Broad On Five-Year Mission To Search For Novel Cancer Therapeutics

Banook Central Imaging, Oncodesign partner to expand use of new approaches in pharmaco-imaging

Viewpoints: Administration is 'fighting back' on Obamacare; Democrats' 'nervous breakdown' about GOP inquiry on navigators

Bioinformatics researchers investigate functional diversity of proteins

Scientists identify enzyme mutation that occurs in castration-resistant prostate cancer

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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