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Scientists explore brainstem circuits to find nausea intervention strategies

In a new study, researchers uncovered the organization of nausea-associated brainstem circuits to show that selectively blocking the excitatory neurons responsive to nausea-promoting growth/differentiation factor 15 suppresses nausea-related behaviors.

20 Jun 2022

Genetic discovery may pave the way to new diagnostic approaches, treatments for motor neurone diseases

A new genetic discovery adds weight to a theory that motor neurone degenerative diseases are caused by abnormal lipid (fat) processing pathways inside brain cells.

20 Jun 2022

Overt and occult hypoxemia in patients hospitalized with COVID-19

In a recent study posted to the medRxiv* preprint server, researchers assessed whether non-invasive estimation of the ratio of arterial oxygen partial pressure (PaO2) to the fractional inspired oxygen (Fi O2), i.e., the P/F ratio could measure overt and occult hypoxemia in coronavirus disease 2019 (COVID-19) patients.

20 Jun 2022

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

Gut microbiome acts on the brain to control appetite

Hypothalamic GABAergic neurons recognize microbial muropeptides through the cytosolic receptor NOD2, which regulates food intake and body temperature.

19 Jun 2022

Multifunctional nanoparticle system may be a promising therapeutic way for breast cancer therapy

In this new article publication from Acta Pharmaceutica Sinica B, authors Yun Yang, Danrong Hu, Yi Lu, Bingyang Chu, Xinlong He, Yu Chen, Yao Xiao, Chengli Yang, Kai Zhou, Liping Yuan and Zhiyong Qian from Sichuan University, Chengdu discuss tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy.

18 Jun 2022

Study points to a new direction for the development of NAMPT-targeted cancer therapies

In this new article publication from Acta Pharmaceutica Sinica B, authors Ying Wu, Congying Pu, Yixian Fu, Guoqiang Dong, Min Huang and Chunquan Sheng from Second Military Medical University, Shanghai, China and University of Chinese Academy of Sciences, Shanghai, China discuss how NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion.

18 Jun 2022

New method can safely free patients from lifelong immunosuppression after kidney transplant

Physicians at Stanford Medicine have developed a way to provide pediatric kidney transplants without immune-suppressing drugs.

17 Jun 2022

Co-development of three systems linked with baby's respiratory health

A new multidisciplinary study conducted by researchers at the University of Rochester Medical Center has found that the co-development of three systems, the gut microbiome, respiratory system and immune system, is correlated with a baby's respiratory health, and an infant can have negative respiratory outcomes if the development of one of these systems is disrupted.

17 Jun 2022

Research may open door to the design of a better structured rabies vaccine

Rabies virus kills a shocking 59,000 people each year, many of them children. Some victims, especially kids, don't realize they've been exposed until it is too late.

17 Jun 2022

Traumatic brain injury changes the connections between nerve cells across the entire brain

Scientists from the University of California, Irvine have discovered that an injury to one part of the brain changes the connections between nerve cells across the entire brain.

17 Jun 2022

New discovery could lead to the development of therapeutic approaches for retinitis pigmentosa

Retinitis pigmentosa, a degenerative genetic disease of the eye, is characterized by progressive vision loss, usually leading to blindness.

17 Jun 2022

Study explains the structural basis of higher ACE2 binding affinity of Omicron sub-variants

A team of scientists from China has recently deciphered the structural basis of comparatively higher binding affinity of two Omicron sub-variants, namely B.1.1 and B.2, for human angiotensin-converting enzyme 2 (ACE2).

17 Jun 2022

Researchers investigate COVID fog and chemokine C–C motif ligand 11

Researchers assessed the characteristics of the brain fog reported by some COVID-19 patients.

17 Jun 2022

Scientists explore effectiveness of neutralizing antibodies against SARS-CoV-2 Omicron variant

Researchers assessed the impact of SARS-CoV-2-neutralizing antibodies on the SARS-CoV-2 Omicron variant.

17 Jun 2022

Conceptual framework to examine the patterns of copy number alterations in human cancer

A new study published in Nature presented a conceptual framework to examine the patterns of copy number alterations in human cancer.

17 Jun 2022

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

In a recent study posted to the bioRxiv* pre-print server, researchers at Cornell University College of Veterinary Medicine and the University of Illinois Urbana-Champaign compared the infection dynamics, pathogenicity, and tissue tropism of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in adult cats.

17 Jun 2022

GPR183 gene a novel drug target for severe COVID-19

In a recent study posted to the bioRxiv* pre-print server, researchers provide the first preclinical evidence of the usefulness of antagonists of G-protein coupled receptor 183 (GPR183), also known as Epstein-Barr virus-induced gene 2 (EBI2), in reducing coronavirus disease 2019 (COVID-19) severity.

17 Jun 2022

HIV coinfection significantly impacts B cell response to SARS-CoV-2

In recent research posted to the bioRxiv* preprint server, investigators confirmed that human immunodeficiency virus (HIV) co-infection alters B cell reaction in coronavirus disease 2019 (COVID-19).

17 Jun 2022

Ancient DNA unravels the mystery of the Black Death

In a recent study published in the Nature journal, researchers illustrated that the Black Death pandemic caused by Yersinia pestis originated in central Eurasia during the 14th century.

17 Jun 2022

Cell News and Research

Scientists explore brainstem circuits to find nausea intervention strategies

Genetic discovery may pave the way to new diagnostic approaches, treatments for motor neurone diseases

Overt and occult hypoxemia in patients hospitalized with COVID-19

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

Gut microbiome acts on the brain to control appetite

Multifunctional nanoparticle system may be a promising therapeutic way for breast cancer therapy

Study points to a new direction for the development of NAMPT-targeted cancer therapies

New method can safely free patients from lifelong immunosuppression after kidney transplant

Co-development of three systems linked with baby's respiratory health

Research may open door to the design of a better structured rabies vaccine

Traumatic brain injury changes the connections between nerve cells across the entire brain

New discovery could lead to the development of therapeutic approaches for retinitis pigmentosa

Study explains the structural basis of higher ACE2 binding affinity of Omicron sub-variants

Researchers investigate COVID fog and chemokine C–C motif ligand 11

Scientists explore effectiveness of neutralizing antibodies against SARS-CoV-2 Omicron variant

Conceptual framework to examine the patterns of copy number alterations in human cancer

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

GPR183 gene a novel drug target for severe COVID-19

HIV coinfection significantly impacts B cell response to SARS-CoV-2

Ancient DNA unravels the mystery of the Black Death

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