Protein C News and Research

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Scientists identify new therapeutic targets for SARS-CoV-2

To identify new potential therapeutic targets for SARS-CoV-2, a team of scientists at the New York Genome Center, New York University, and the Icahn School of Medicine at Mount Sinai, performed a genome-scale, loss-of-function CRISPR screen to systematically knockout all genes in the human genome.

27 Oct 2020

Study: SARS-CoV-2 virus adopts new strategy to ensure its replication, spread

Since COVID-19 began its menacing march across Wuhan, China, in December 2019, and then across the world, the SARS-CoV-2 virus has taken a "whatever works" strategy to ensure its replication and spread.

27 Oct 2020

Study reveals human protein that helps the immune system fight viral infections

University of North Carolina School of Medicine scientists has made a curious discovery about a well-known human protein that helps the immune system fight viral infections.

27 Oct 2020

Study: Ketogenic diets can prevent or reverse heart failure caused by metabolic process

Research from Saint Louis University finds that high fat or "ketogenic" diets could completely prevent, or even reverse heart failure caused by a metabolic process.

27 Oct 2020

COVID-19 vaccine tracker provides real-time updates on effective vaccine

McGill University professor Nicole Basta and her team have created an interactive online COVID-19 vaccine tracker, that provides real-time updates on progress in developing a safe and effective vaccine.

27 Oct 2020

New technique can detect TDP-43 protein in patients with ALS and frontotemporal dementia

A test to diagnose two very serious diseases such as ALS and FTD when the pathologies have not yet appeared, thereby providing doctors and patients with essential information tools to tackle them early and develop new treatments.

27 Oct 2020

Cellular senescence variations may control health and onset of age-related diseases

Researchers from Kumamoto University, Japan have proposed that cellular senescence variations during the aging process could lead to control of health and onset of age-related diseases.

27 Oct 2020

Anti-inflammatory mediator may play key role in wound healing

"Wound healing is one of the most complex biological processes," writes Professor Kazumitsu Sugiura and Dr. Kenta Saito from Fujita Health University, Japan, in their article recently published in Nature's Scientific Reports.

27 Oct 2020

Expression of a specific gene could regulate feelings of fear and its extinction

Fear and fear extinction learning are adaptive processes caused by molecular changes in specific brain circuits, and they're perturbed in conditions such as anxiety and post-traumatic stress disorder.

27 Oct 2020

Researchers identify a new way to prevent skin reactions in cancer patients

Using the body's immune system to fight cancer has great potential, but can also bring serious side effects, including itchy and painful skin reactions.

27 Oct 2020

Researchers identify effective way to protect vulnerable people from COVID-19

T-cells taken from the blood of people who recovered from a COVID-19 infection can be successfully multiplied in the lab and maintain the ability to effectively target proteins that are key to the virus's function, according to a new study published Oct. 26 in Blood.

27 Oct 2020

Novel insights open up new avenues for treating autoimmune conditions

Immune response is a balancing act: Too much can lead to inflammatory or autoimmune disease; too little could lead to a serious infection. Regulatory T cells, or Tregs, are important players in striking this balance, acting as "brakes" on the immune response so it doesn't go overboard.

27 Oct 2020

Genome-wide screens reveal new helpful and harmful COVID-19 related genes

Researchers at Yale University and the Broad Institute of MIT and Harvard screened hundreds of millions of cells exposed to the COVID-19 and MERS viruses and identified dozens of genes that both enable the viruses to replicate in cells and also those that seem to slam the door on the virus.

27 Oct 2020

Scientists identify new target for developing novel drugs against several types of cancer

The Bcl-2 protein family comprises anti- and proapoptotic members, i.e. they protect the cell from death or favour it.

27 Oct 2020

Study analyzes link between clonal hematopoiesis and treatment-related blood cancer risk

In recent years, improvements in cancer therapy have led to a significant increase in cancer survivorship. Experts estimate that by 2022, the United States will have 18 million cancer survivors, but a subset of those survivors will have long-term health problems to be addressed.

27 Oct 2020

New research on small non-coding RNAs and SARS-CoV-2

A recently published mini-review in the Frontiers in Microbiology on the altered expression of small non-coding RNAs during coronavirus-mediated infections.

26 Oct 2020

Phase 1 trial results of gorilla adenovirus vaccine for COVID-19

A recent study published on the preprint server bioRxiv* in October 2020 reports the development of a novel vaccine based on a simian adenoviral vector obtained from a group C gorilla isolate called GRAd32. This could help speed up vaccine development.

26 Oct 2020

New peptide derivatives that target the SARS-CoV-2 spike protein

In a new study published in the journal Cellular and Molecular Bioengineering, researchers report peptide derivatives, or peptidomimetics, based on the circle residues involved in the interaction of the spike protein and ACE2.

26 Oct 2020

Study suggests 5’UTR of SARS-CoV-2 might be of pangolin coronavirus origin

Findings from a new genomic sequencing study support the hypothesis that the pangolin was the intermediate host for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that enabled transmission of the virus to humans.

26 Oct 2020

Research uncovers SARS-CoV-2 viral traits critical for the virus in human airways

A new study published on the preprint server bioRxiv* in October 2020 reports the discovery of important viral genomic features that are crucial to its replication in the human airway cells, and its enhancing mutations which increase the rate of replication and determine its target cells.

26 Oct 2020