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Coaxial electrospinning could lead to new medical innovations

When you visit Andrew Steckl's lab at the University of Cincinnati, you see a nondescript glass box that weaves together different fibers.

25 Oct 2019

Study compares safety and effectiveness of first-line antihypertensive drug classes

For those with extremely high blood pressure, or hypertension, there are many initial medication options -- so many that it can be hard to know which one to use.

25 Oct 2019

Phase 2 clinical trial of CAR T-cell therapy starts at Atlantic Health System

Atlantic Health System is treating patients in a new Phase 2 clinical trial of CAR T-cell therapy at Morristown Medical Center. A select number of sites across the U.S. are involved in this study, which is done on an outpatient basis.

25 Oct 2019

Researchers find antibody that may protect against wide range of lethal influenza viruses

A nationwide team of researchers has found an antibody that protects mice against a wide range of potentially lethal influenza viruses, advancing efforts to design of a universal vaccine that could either treat or protect people against all strains of the virus.

25 Oct 2019

Using wastewater to map global use of illicit drugs

Wastewater-based epidemiology is a rapidly developing scientific discipline with the potential for monitoring close to real-time, population-level trends in illicit drug use.

25 Oct 2019

First-line antihypertensives may not be most effective, study shows

Thiazide diuretics demonstrate better effectiveness and cause fewer side effects than ACE inhibitors as first-line antihypertensive drugs, according to a report published Oct. 24 in The Lancet.

25 Oct 2019

Study explores distribution of new diabetes cases and specialist density in the U.S.

In the last five years, the landscape of type 2 diabetes treatment has changed dramatically. Two new classes of drugs -- SGLT2 inhibitors and GLP-1 receptor agonists -- have been shown to prevent some of the most serious diabetes complications, including heart and kidney conditions, in patients.

25 Oct 2019

Pharma sells states on ‘Netflix model’ to wipe out hep C. But at what price?

When a long, black bus bearing the logo of drugmaker AbbVie rolls through Washington state next year, it will promote a new effort to eradicate hepatitis C infections.

25 Oct 2019

Most popular first-line treatment for hypertension may be less effective than alternative drugs

A new multinational study shows that the most popular first-line treatment for hypertension is less effective and has more side effects than an alternative that's prescribed much less often.

25 Oct 2019

Researchers discover how the body repairs damaged DNA

Researchers from the University of Copenhagen have made an extraordinary discovery in how the body repairs damaged DNA, which can lead to better understanding and management of diseases such as cancer.

25 Oct 2019

Genetically definable subgroups of cancers sensitive to treatment

Precision oncology aims to use genetic features of a patient's tumor to tailor anti-cancer therapy. DNA mutations in a drug target have provided a number of therapeutic opportunities; however, there are many cancer types that do not have obvious targetable mutations.

24 Oct 2019

Study opens up array of options for developing treatments for cancer or autoimmune disorder

Immunologists at St. Jude Children's Research Hospital have discovered key biological switches that control regulatory T cells--specialized white blood cells that keep the immune system in check.

24 Oct 2019

Study aims to learn more about silent infarction, cognitive decline linked to silent stroke

Can you have a stroke and not know it? Unfortunately, yes. It is a phenomenon called a silent stroke or, more formally, a silent cerebral infarction. Investigators at the University of Alabama at Birmingham and Stanford University want to learn more about silent strokes and their role in brain health, including dementia.

24 Oct 2019

Metabolite profiling during diagnosis helps identify poor treatment outcomes in ALL

The survival of patients with pediatric acute lymphoblastic leukemia (ALL) has significantly improved in the last several decades. However, novel strategies to identify cases that are likely to respond poorly to treatment are still needed.

24 Oct 2019

Gene linked to schizophrenia likely confers risk for illness

Researchers have discovered in mice how one of the few genes definitively linked to schizophrenia, called SETD1A, likely confers risk for the illness. Mice genetically engineered to lack a functioning version of the enzyme-coding gene showed abnormalities in working memory, mimicking those commonly seen in schizophrenia patients.

24 Oct 2019

Optimal implementation of existing, new interventions essential to end HIV pandemic

Optimal implementation of existing HIV prevention and treatment tools and continued development of new interventions are essential to ending the HIV pandemic, National Institutes of Health experts write in a commentary Clinical Infectious Diseases.

24 Oct 2019

Proactive administration of amiodarone to patients after common heart surgery improves outcomes

Proactive administration of amiodarone to patients recovering from a common heart surgery shows promise in preventing postoperative atrial fibrillation, a serious and expensive complication with potential long-term consequences.

24 Oct 2019

Study reveals novel druggable driver gene in human gastrointestinal stromal tumors

Sarcomas - cancers that arise from transformed mesenchymal cells (a type of connective tissue) - are quite deadly. Gastrointestinal stromal tumors are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase.

24 Oct 2019

Study: More than 300 million people affected worldwide by rare diseases

Rare diseases represent a global problem. Until now, the lack of data made it difficult to estimate their prevalence.

24 Oct 2019

Researchers discover unexpected role of mTORC2 protein in colorectal cancer

New results from researchers at MedUni Vienna's Center for Pathobiochemistry and Genetics show that a protein called mTORC2, which is the target of newly developed cancer drugs, is not even active in colorectal cancer. mTORC2 activity was only found in certain immune cells, which actually need this protein to fight cancer cells.

24 Oct 2019

Drugs News and Research

Coaxial electrospinning could lead to new medical innovations

Study compares safety and effectiveness of first-line antihypertensive drug classes

Phase 2 clinical trial of CAR T-cell therapy starts at Atlantic Health System

Researchers find antibody that may protect against wide range of lethal influenza viruses

Using wastewater to map global use of illicit drugs

First-line antihypertensives may not be most effective, study shows

Study explores distribution of new diabetes cases and specialist density in the U.S.

Pharma sells states on ‘Netflix model’ to wipe out hep C. But at what price?

Most popular first-line treatment for hypertension may be less effective than alternative drugs

Researchers discover how the body repairs damaged DNA

Genetically definable subgroups of cancers sensitive to treatment

Study opens up array of options for developing treatments for cancer or autoimmune disorder

Study aims to learn more about silent infarction, cognitive decline linked to silent stroke

Metabolite profiling during diagnosis helps identify poor treatment outcomes in ALL

Gene linked to schizophrenia likely confers risk for illness

Optimal implementation of existing, new interventions essential to end HIV pandemic

Proactive administration of amiodarone to patients after common heart surgery improves outcomes

Study reveals novel druggable driver gene in human gastrointestinal stromal tumors

Study: More than 300 million people affected worldwide by rare diseases

Researchers discover unexpected role of mTORC2 protein in colorectal cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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