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Genome arrangement of tree ferns offers insights into its evolution

Land plants evolved 470 million years ago from algae and have since reshaped our world. Throughout their evolution, ferns have undergone a series of changes that have helped them survive on land.

25 Jul 2022

IU researchers evaluate the efficacy of a failed clinical trial drug for Alzheimer's using rigorous pipeline

Most drugs developed to treat Alzheimer's disease have for years been ineffective in clinical trials. Researchers from Indiana University School of Medicine recently evaluated the efficacy of a failed clinical trial drug using their rigorous pipeline.

25 Jul 2022

UTHSC investigators secure $2.16 million to test a new way to combat neurodegenerative disorders

The National Institute on Aging recently awarded $2.16 million to a team of investigators from the University of Tennessee Health Science Center (UTHSC) testing a new way to combat the root cause of neurodegenerative disorders such as Alzheimer's Disease.

22 Jul 2022

Oligomeric molecular structure of the MOR-Gal1R complex revealed

A study published in the journal Pharmacological Research reveals the oligomeric molecular structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic and addictive effects of certain opioids.

22 Jul 2022

Phase 2a clinical trial describes safety and efficacy of dendrimer nanotherapy in severe COVID-19 patients

A multicenter, randomized, placebo-controlled phase 2a clinical trial has recently been conducted to evaluate the efficacy of a nanotherapeutic compound OP-101 in treating severe COVID-19 patients.

21 Jul 2022

Nanotherapeutic compound may help treat inflammation, brain injury in patients with severe COVID-19

An anti-inflammatory compound may have the potential to treat systemic inflammation and brain injury in patients with severe COVID-19 and significantly reduce their chances of death, according to a new study from UTHealth Houston and other institutions.

20 Jul 2022

Could Vitamin B6 Reduce Anxiety and Depression?

In this interview, we speak to Dr. David Field about his latest research into anxiety and depression and whether vitamin B6 supplements could help to reduce it.

19 Jul 2022

Research describes one of the ways the SARS-CoV-2 virus recruits cells to replicate

An article published in the journal Frontiers in Cellular and Infection Microbiology reports a study by researchers at the State University of Campinas (UNICAMP) and the University of São Paulo (USP) in Brazil showing how a human protein interacts with a SARS-CoV-2 protein, and describing one of the ways the virus that causes COVID-19 recruits cells to replicate.

18 Jul 2022

As Big Pharma loses interest in new antibiotics, infections are only growing stronger

Forget covid-19, monkeypox, and other viruses for the moment and consider another threat troubling infectious disease specialists: common urinary tract infections, or UTIs, that lead to emergency room visits and even hospitalizations because of the failure of oral antibiotics.

15 Jul 2022

Discovery of multiple new SARS-CoV-2 MPro inhibitors

In a recent study posted to the bioRxiv* preprint server, researchers performed an extensive library docking for new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) covalent and non-covalent inhibitors.

8 Jul 2022

A need for more research on toxicity of cannabis vaping products

Scientists assess the challenges presented by cannabinoid vaping products during the analysis of their effect on consumers’ respiratory health.

7 Jul 2022

New biosensor system derived from E. coli bacteria could accelerate drug development

For more affordable, sustainable drug options than we have today, the medication we take to treat high blood pressure, pain or memory loss may one day come from engineered bacteria, cultured in a vat like yogurt.

7 Jul 2022

Researchers find a way to kill recurring prostate cancer with a lot of iron

Prostate cancer can come back from common hormone deprivation therapy with a vengeance and no clear treatment option, but scientists have early evidence that one way to kill these recurring cancer cells may be with a lot of iron.

7 Jul 2022

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

A new study investigated the role of complement component 5a (C5a) and its receptor (C5a receptor type 1, C5aR1) in the pathophysiology of COVID-19.

6 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

'Phantom' networks undermine access to mental health care for patients most in need, study says

Amid a surge in demand for mental health care, a new report from researchers at Oregon Health & Science University finds almost six out of 10 in-network providers listed under Oregon Medicaid provider directories are not actually available to see patients.

5 Jul 2022

Novel oral nano-in-micro system provides efficient curcumin delivery to alleviate ulcerative colitis

A new study showed that the newly designed oral nano-in-micro hydrogel delivery platform could be efficiently used to deliver curcumin for the treatment of Ulcerative Colitis.

5 Jul 2022

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases.

4 Jul 2022

UTSA chemistry professor awarded NSF grant to advance research on the body's metabolic processes

Chemistry professor Aimin Liu has been awarded a three-year, $495,000 Accomplishment-Based Renewal (ABR) grant from the National Science Foundation (NSF) to advance his research on the body's metabolic processes using an innovative method that will improve the understanding of amino acids.

1 Jul 2022

Identification of potent SARS-CoV-2 macrodomain inhibitors

A recent study posted to the bioRxiv* preprint server illustrated the optimization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 3 (NSP3) macrodomain (Mac) inhibitor based on structure.

30 Jun 2022

Compound News and Research

Genome arrangement of tree ferns offers insights into its evolution

IU researchers evaluate the efficacy of a failed clinical trial drug for Alzheimer's using rigorous pipeline

UTHSC investigators secure $2.16 million to test a new way to combat neurodegenerative disorders

Oligomeric molecular structure of the MOR-Gal1R complex revealed

Phase 2a clinical trial describes safety and efficacy of dendrimer nanotherapy in severe COVID-19 patients

Nanotherapeutic compound may help treat inflammation, brain injury in patients with severe COVID-19

Could Vitamin B6 Reduce Anxiety and Depression?

Research describes one of the ways the SARS-CoV-2 virus recruits cells to replicate

As Big Pharma loses interest in new antibiotics, infections are only growing stronger

Discovery of multiple new SARS-CoV-2 MPro inhibitors

A need for more research on toxicity of cannabis vaping products

New biosensor system derived from E. coli bacteria could accelerate drug development

Researchers find a way to kill recurring prostate cancer with a lot of iron

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

'Phantom' networks undermine access to mental health care for patients most in need, study says

Novel oral nano-in-micro system provides efficient curcumin delivery to alleviate ulcerative colitis

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

UTSA chemistry professor awarded NSF grant to advance research on the body's metabolic processes

Identification of potent SARS-CoV-2 macrodomain inhibitors

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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