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30-year-old cancer drug could get another shot, study says

A study by Virginia Commonwealth University Massey Cancer Center researchers published in today's print edition of Molecular Cancer Therapeutics shows that triplatin is effective against triple negative breast cancer, which is the most aggressive form of breast cancer and has few targeted therapies.

9 Feb 2022

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory.

8 Feb 2022

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

8 Feb 2022

Efficacy of MVA-CoV2-S vaccination to prevent SARS-CoV-2 cerebral infection and associated damage

Researchers demonstrated that an MVA vector expressing the SARS-CoV-2 spike protein was 100% effective in preventing neuroinvasion and brain damage by SARS-CoV-2 in transgenic mice.

8 Feb 2022

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

New research from North Carolina State University has found that an imprinted gene associated with development of non-alcoholic fatty liver disease (NAFLD) is switched on in mice who nurse from mothers with metabolic syndrome, even when those mice are not biologically related.

7 Feb 2022

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington's disease that recapitulates more Huntington's disease-like characteristics than earlier models.

2 Feb 2022

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

A University of South Florida Health preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

31 Jan 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Study reveals link between muscular dystrophy and sphingolipids

In a new study, the group of Johan Auwerx at EPFL's School of Life Sciences has made the first connection between muscular dystrophy and sphingolipids, a group of bioactive lipids. The study is published in Science Advances.

29 Jan 2022

Study reveals role of a protein in healthy functioning of blood stem cells

A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study from researchers at Weill Cornell Medicine.

28 Jan 2022

Novel molecular signaling pathway plays a key role in producing osteoarthritis pain

Researchers from North Carolina State University have discovered that a particular molecular signaling pathway plays an important role in producing osteoarthritis (OA) pain.

27 Jan 2022

Unhealthy vaginal microbiome in mothers may contribute to infant deaths and altered development

A new study in mice from University of Maryland School of Medicine researchers showed that an unhealthy vaginal microbiome in pregnant mothers in combination with an unhealthy diet contributed to increased pup deaths and altered development in the surviving babies.

27 Jan 2022

Mouse Model News and Research

30-year-old cancer drug could get another shot, study says

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Efficacy of MVA-CoV2-S vaccination to prevent SARS-CoV-2 cerebral infection and associated damage

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Study reveals link between muscular dystrophy and sphingolipids

Study reveals role of a protein in healthy functioning of blood stem cells

Novel molecular signaling pathway plays a key role in producing osteoarthritis pain

Unhealthy vaginal microbiome in mothers may contribute to infant deaths and altered development

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

Broad and potent neutralizing activity of human IgG1 LALA antibody against SARS-CoV-2 variants

Novel experimental drug designed to silence FUS gene may help treat ALS

Novel gene therapy for diseased muscle fiber repair

Characterization of unique pathogenesis of SARS-CoV-2 Delta variant in mouse model

Study sheds light on how melanoma primes nearby lymph nodes for tumor metastases

Newly developed gene therapy can treat a severe form of epilepsy and prolong survival

Partial bone marrow transplant can dramatically improve survival of mice with cystic fibrosis

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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