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Researchers discover key details of how rheumatoid arthritis destroys bone

Researchers have discovered key details of how rheumatoid arthritis (RA) destroys bone, according to a study published in the Aug. 22 edition of the Journal of Biological Chemistry. The findings are already guiding attempts to design new drugs to reverse RA-related bone loss and may also address more common forms of osteoporosis with a few adjustments.

24 Aug 2008

New discovery on how rheumatoid arthritis destroys bone

20 Aug 2008

Testosterone and body fat are controlled by the same genes

Genes that control percentage of body fat are also responsible for circulating levels of testosterone in men, research published in the latest edition of Clinical Endocrinology shows. The research shows a 23% overlap between the genes that control testosterone and those that regulate body fat composition, suggesting that these two variables are partly controlled by the same set of genes.

4 Aug 2008

Researchers link the extreme fatigue in pulmonary fibrosis to loss in body-rejuvenating R.E.M. sleep

Family, friends and neighbors remember Lisa Sandler Spaeth as an active mother of two in Potomac, Md., with a lot on the go, juggling her son's baseball games and her daughter's horseback-riding lessons with numerous committee obligations, organizing women's activities at her local synagogue. Add to this Spaeth's thriving home business turned wholesale supplier - making custom hair accessories for children - which she founded with her mother.

29 Jul 2008

Estrogen treatments may sharpen mental performance in some women

Estrogen treatments may sharpen mental performance in women with certain medical conditions, but University of Florida researchers suggest that recharging a naturally occurring estrogen receptor in the brain may also clear cognitive cobwebs.

29 Jul 2008

Laboratory and mouse studies show targeted drug blocks the growth of breast cancer cells that spread to the brain

Using laboratory and mouse models of human breast cancer, researchers have found that a small molecule capable of targeting specific proteins on the surface of breast cancer cells can inhibit the growth of breast cancer cells that migrate to the brain.

29 Jul 2008

Ovulation blocking gene found

A group of Canadian and European researchers have unlocked the mystery of a gene with the potential to both regulate and block ovulation.

17 Jul 2008

GILZ protein may have big role in making more bone and less fat

A small protein may have a big role in helping you make more bone and less fat, researchers say. "The pathways are parallel, and the idea is if you can somehow disrupt the fat production pathway, you will get more bone," says Dr. Xingming Shi, bone biologist at the Medical College of Georgia Institute of Molecular Medicine and Genetics.

1 Jul 2008

Oxygen-rich lifesaving efforts pose risk for respiratory infections

Each year, thousands of premature infants battle to breathe. Thanks to life-saving interventions developed in the past couple decades - steroids given to their mothers to stall pre-term labor, mechanical ventilation, air enriched with extra oxygen, and surfactant, a crucial wetting agent that makes breathing less work - most of these newborns survive with enough lung function to grow and go home.

11 Jun 2008

How the cholesterol-lowering drug ezetimibe (Zetia) works

A new study in the June issue of Cell Metabolism, a Cell Press publication, sheds light on the action of the drug ezetimibe (trade name Zetia), which is used to treat high cholesterol. Ezetimibe is unique among cholesterol-lowering drugs in that it works by cutting the amount of cholesterol taken in from the diet rather than by blocking cholesterol's manufacture in the body.

3 Jun 2008

HIV patients suffer more from osteoporosis

Following the introduction of HAART (Highly Active Antiretroviral Therapy), the survival and quality of life for people infected with the human immunodeficiency virus (HIV-1) have increased in the resource-rich countries. However, with this improved prognosis an increase in long term negative disorders has been observed, namely osteoporosis (the gradual loss of bone mass).

25 May 2008

Evidence mounts against DHEA use in treating cognitive decline

DHEA supplements are widely-available and touted as a preventive agent for many chronic diseases. A new study published in Journal of the American Geriatrics Society finds no evidence of a beneficial effect of DHEA supplements on cognitive function in healthy older adults. The researchers believe that based on their study, DHEA supplements should not be recommended for enhancement of cognitive function or well-being in the general population.

21 May 2008

New treatment option for idiopathic pulmonary fibrosis

Patients with idiopathic pulmonary fibrosis (IPF) may have a new treatment option, according to researchers in Japan.

20 May 2008

New hay fever jab promises year long relief for sufferers

Relief is in sight for millions of hay fever sufferers with the promise of a jab, which lasts for a year, that significantly reduces symptoms.

15 May 2008

New clues into how preeclampsia may surface in some pregnancies

The COMT gene - known already for its role in schizophrenia - has been found to play a role in preeclampsia, according to a report in the advance on-line issue of Nature.

11 May 2008

Corticosteroids provide no survival benefit for children with bacterial meningitis

Corticosteroids given to children who are hospitalized for bacterial meningitis do not provide a benefit in survival or in reduced hospital stays, according to a large multicenter study by pediatric researchers. This finding stands in contrast to previous studies in hospitalized adults, for which corticosteroids dramatically reduced mortality.

6 May 2008

Corticosteroids not linked with reduced risk of death for children with bacterial meningitis

Use of corticosteroids in addition to other treatment for children with bacterial meningitis is not associated with a decreased risk of death or shorter hospital stay, according to a study in the May 7 issue of JAMA, the Journal of the American Medical Association.

6 May 2008

Risk of Bisphenol A in plastic products, Q & A's

Bisphenol A, an estrogenlike compound in polycarbonate plastics and epoxy resin, has been popping up in the news a lot lately.

30 Apr 2008

Factors affecting survival, disability of extremely premature infants identified

Gestational age has long been the factor most commonly used to predict whether an extremely low-birth-weight infant survives and thrives, but four additional factors that can help predict a preemie's outcome have been identified by the National Institutes of Health Neonatal Research Network, of which Yale is a member.

29 Apr 2008

Study explains why steroid therapy for sinusitis and asthma loses its punch over time

Scientists at Johns Hopkins have outlined a new path for potential therapies to combat inflammation associated with sinusitis and asthma based on a new understanding of the body's earliest immune response in the nose and sinus cavities.

29 Apr 2008