Protein C News and Research

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ACE2 binding causes dissociation of trimeric SARS-CoV-2 spike, may be used to inhibit further infection

A recent study published on the preprint server bioRxiv in October 2020 shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binding to the human host receptor could cause the typical trimeric spike protein to come apart, forming a stable monomer instead with the receptor.

14 Oct 2020

Scientists produce biodegradable nanocoating with antimicrobial and anti-reflective properties

Scientists from Russia and Switzerland have probed into nanostructures covering the corneas of the eyes of small fruit flies. Investigating them the team learned how to produce the safe biodegradable nanocoating with antimicrobial, anti-reflective, and self-cleaning properties in a cost-effective and eco-friendly way.

14 Oct 2020

Study shows SARS-CoV-2 antibodies offer lasting immunity

One of the most significant questions about the novel coronavirus is whether people who are infected are immune from reinfection and, if so, for how long.

14 Oct 2020

Modification of DNA structure plays key role in the recovery phase after DNA damage

A research team from Cologne has discovered that a change in the DNA structure - more precisely in the chromatin - plays a decisive role in the recovery phase after DNA damage.

14 Oct 2020

3D structural model of BAF complex modifies DNA architecture, provides clues on cancer

Scientists have created an unprecedented 3-dimensional structural model of a key molecular "machine" known as the BAF complex, which modifies DNA architecture and is frequently mutated in cancer and some other diseases.

14 Oct 2020

SARS-CoV-2 spike protein triggers cell signaling pathways in lung vascular cells

A new study published on the preprint server bioRxiv in October 2020 shows that vascular cells in the lung tissue begin to secrete signaling growth factors when exposed to just the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), without the rest of the viral components.

14 Oct 2020

SARS-CoV-2 infection of carotid arteries may explain vascular involvement in COVID-19

A new study published on the preprint server bioRxiv in October 2020 shows that the virus causing COVID-19, namely, SARS-CoV-2, produces replicative infection in the carotid arteries and affects the vascular responses. This could have a profound bearing on the understanding of the disease and its clinical treatment.

14 Oct 2020

New clinical trial to test safety and efficacy of antibody cocktail against COVID-19

In a new clinical trial, UC Davis Health will test the effectiveness and safety of REGN-COV2, the monoclonal antibody cocktail, in preventing COVID-19 in adults living with infected patients.

14 Oct 2020

Researchers create multi-functional nano-vaccine to prevent toxoplasmosis

Fighting clever parasites requires smart vaccines that can trigger critical immune responses. A University of Chicago-based research team has found a novel way to do that.

14 Oct 2020

Researchers are developing a new class of compounds against various cancers

Researchers at The Wistar Institute and collaborators from the University of Notre Dame are developing anticancer compounds targeting a pathway of the endoplasmic reticulum (ER) stress response implicated in the development of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and lymphoma.

14 Oct 2020

D614G mutation in SARS-CoV-2 increases viral fitness and infectivity

Researchers from the Duke Human Vaccine Institute and Duke University, Durham NC, USA, recently analyzed the D614G mutation in SARS-CoV-2 in the context of a soluble S ectodomain construct. Their study has been published in the preprint server bioRxiv.

14 Oct 2020

Pre-existing immunity to other coronaviruses may be poor

Brenda M. Westerhuis et al., in a recent medRxiv* preprint paper, investigate the antibody cross-reactivity - to explain the severe disease. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

13 Oct 2020

Scientists combine a chemotherapeutic and photodynamic approach to fight cancer

In their quest to destroy cancer cells, researchers are turning to combinational therapies more and more. Scientists from Germany and China have now combined a chemotherapeutic and photodynamic approach.

13 Oct 2020

Drug derived from a natural human protein could stop lethal lung damage from the flu

The raging lung inflammation that can contribute to death from the flu can be stopped in its tracks by a drug derived from a naturally occurring human protein, a new animal study suggests.

13 Oct 2020

Are antibiotics being over prescribed in COVID-19?

A new study published on the preprint server medRxiv in October 2020 shows that the baseline levels of inflammatory markers and C-reactive protein (CRP) in relation to antibiotic administration can rule out bacterial co-infections and help reduce the unnecessary use of antibiotics.

13 Oct 2020

Novel findings on mole growth could pave way for skin cancer treatments

Moles stop growing when they reach a certain size due to normal interactions between cells, despite having cancer-associated gene mutations, says a new study published today in eLife.

13 Oct 2020

New computational approach improves characterization of cellular diversity

Researchers in the United States have developed a computational method called “weighted-nearest neighbor” (WNN) analysis that can significantly improve the ability to define cellular states across various biological contexts and data types.

13 Oct 2020

CAR NKT cells offer a promising approach to combat hard-to-treat solid tumors

Natural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have been developed into a novel form of immunotherapy to treat patients with cancer.

13 Oct 2020

How SARS-CoV-2's spike protein highjacks the host cell trafficking machinery

Researchers at The Medical Research Council Laboratory of Molecular Biology have conducted a study showing how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein interacts with host cell factors in ways that promote the formation of syncytia.

13 Oct 2020

New therapy may help treat or prevent multiple sclerosis

Multiple sclerosis, an autoimmune disease of the central nervous system that affects millions worldwide, can cause debilitating symptoms for those who suffer from it.

13 Oct 2020

Protein C News and Research

ACE2 binding causes dissociation of trimeric SARS-CoV-2 spike, may be used to inhibit further infection

Scientists produce biodegradable nanocoating with antimicrobial and anti-reflective properties

Study shows SARS-CoV-2 antibodies offer lasting immunity

Modification of DNA structure plays key role in the recovery phase after DNA damage

3D structural model of BAF complex modifies DNA architecture, provides clues on cancer

SARS-CoV-2 spike protein triggers cell signaling pathways in lung vascular cells

SARS-CoV-2 infection of carotid arteries may explain vascular involvement in COVID-19

New clinical trial to test safety and efficacy of antibody cocktail against COVID-19

Researchers create multi-functional nano-vaccine to prevent toxoplasmosis

Researchers are developing a new class of compounds against various cancers

D614G mutation in SARS-CoV-2 increases viral fitness and infectivity

Pre-existing immunity to other coronaviruses may be poor

Scientists combine a chemotherapeutic and photodynamic approach to fight cancer

Drug derived from a natural human protein could stop lethal lung damage from the flu

Are antibiotics being over prescribed in COVID-19?

Novel findings on mole growth could pave way for skin cancer treatments

New computational approach improves characterization of cellular diversity

CAR NKT cells offer a promising approach to combat hard-to-treat solid tumors

How SARS-CoV-2's spike protein highjacks the host cell trafficking machinery

New therapy may help treat or prevent multiple sclerosis

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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