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New model of p53 regulation has important implications for the development of anticancer drugs

Genetically engineered mice convinced scientists at the Salk Institute for Biological Studies that it was time to overhaul widely held beliefs about how a powerful tumor suppressor called p53 is controlled in cells. Their new model of p53 regulation has important implications for the development of anticancer drugs.

11 Apr 2006

If parents snore, chances are child will also

According to researchers in the U.S. if either parent is a snorer, a child is three times more likely to be a noisy sleeper.

11 Apr 2006

U.S. watchdog says Xenical should be withdrawn

A consumer watchdog group in the U.S., Public Citizen, has petitioned the U.S. Food and Drug Administration (FDA) to withdraw the prescription diet drug Xenical (orlistat) from the market; the group also want the FDA to refuse approval for the weight-loss pill to be made widely available over the counter.

11 Apr 2006

Research explains why recipients of growth hormone therapy may develop colon polyps

The use of growth hormone therapy has been linked in some people to the development of colon polyps, a possible precursor to colorectal cancer - but medical researchers have debated the extent of a cancer risk.

11 Apr 2006

Targeted mutations in mice uncover two key molecular events linked to learning

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells.

11 Apr 2006

Streptococcal toxic shock syndrome caused by Streptococcus suis Serotype 2

Last year, there was major press coverage of an alarmingly large and deadly outbreak of Streptococcus suis disease in Sichuan province in China.

11 Apr 2006

Gene variant doubles risk for obsessive-compulsive disorder

Scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive-compulsive disorder (OCD).

11 Apr 2006

Colorimetric screening detects DNA, small molecules and proteins

Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anti-cancer drugs.

11 Apr 2006

Study illustrates contribution of obesity to decreased mobility in high functioning older women with osteoarthritis

Osteoarthritis, common among older adults, is strongly linked to late-life disability, but the process by which this happens has not been well studied.

11 Apr 2006

Epstein-Barr virus infection linked to multiple sclerosis

Young adults with high levels of antibodies against the Epstein-Barr virus, the virus that most often causes mononucleosis, may be more likely to develop multiple sclerosis 15 to 20 years later, according to a study in the Archives of Neurology.

11 Apr 2006

A history of stroke is related to a progressive decline in memory

A history of stroke may be associated with progressive memory difficulties in patients without dementia or cognitive impairment, according to a study in the April issue of Archives of Neurology.

11 Apr 2006

Genetic variants in estrogen-related genes linked to Parkinson's disease in women

Mayo Clinic researchers have discovered a possible connection between increased risk for Parkinson's disease and variants in three genes that control estrogen production and activity in the body.

11 Apr 2006

Access to breast cancer wonder drug will depend on where you live

Access to a potentially life-saving breast cancer drug in the UK has nothing to do with need but rather where they happen to live.

10 Apr 2006

Protein loss linked to colon polyp risk from growth hormone

10 Apr 2006

Proteins could help predict whether moles will progress into melanoma

For the first time, researchers studying patients with abnormal moles have identified proteins that could help predict whether such moles will progress into melanoma, the deadliest form of skin cancer.

7 Apr 2006

Photodynamic therapy may become the first line of treatment for Barrett's esophagus

When you think of heartburn, you probably think of greasy food, not cancer. You may not know that chronic heartburn is linked to esophageal cancer.

7 Apr 2006

Scientists gauge pain in premature babies

Scientists at UCL (University College London) have measured responses to pain in the brains of premature babies and have shown that they are likely to experience ‘true’ pain rather than simply displaying reflex reactions.

6 Apr 2006

Researchers identify internal electron transfer mechanism of cell respiration

Researchers at the Institute of Biotechnology of the University of Helsinki have for the first time identified an internal electron transfer reaction that initiates the proton pump mechanism of the respiratory enzyme.

6 Apr 2006

MIT look at how cells make life-or-death decisions

The biological processes underlying diseases such as rheumatoid arthritis and cancer are fundamentally linked, and should be linked in how they are treated with drugs, a series of MIT studies indicates.

6 Apr 2006