Genetic Engineering News and Research

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New drug treatment linked to higher bladder compliance after spinal cord injury

Researchers have shown that compared to placebo, a drug treatment intended to prevent remodeling of the bladder wall and given within 48 hours after spinal cord injury (SCI) in dogs was associated with significantly higher bladder compliance.

7 Sep 2017

Research shows new method for rapidly producing antimalarial drug at industrial scale

Compared to smallpox or typhoid, malaria is proving one of the most challenging human diseases to eradicate - and so remains a real and constant danger to nearly half the world's population.

7 Sep 2017

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Significant headway has been made in controlling malaria. However, two vexing problems remain: currently available treatments are unable to block transmission of the parasite that causes the disease, and the parasite often becomes resistant to drugs.

7 Sep 2017

New DNA sequencing technology measures effects of thousands of sequences on gene activity

When a gene is switched on, various stretches of DNA nearby act as 'control dials', influencing the level of activity and the amount of gene product that is made.

7 Sep 2017

Research provides new insights into secret life of bacteria

Bacterial infections are the number one cause of death in hospital patients in the United States, and antibiotic-resistant bacteria are on the rise, causing tens of thousands of deaths every year.

6 Sep 2017

Antibiotics may kill bacteria differently in vitro vs in vivo

Understanding exactly how antibiotics work (or don’t work) is crucial for developing alternative treatment strategies, not only to target new “superbugs,” but also to make existing drugs more effective against their targets.

5 Sep 2017

Aberrant neural activity in lab mice presents potential challenges to study healthy brain

Multiple laboratories have observed unusual neural activity resembling epilepsy in some lines of genetically modified mice widely used in neuroscience research.

4 Sep 2017

Mayo Clinic experts move closer to realizing clinical potential of senolytic drugs on aging

Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals.

4 Sep 2017

Researchers explore causal link between perirhinal neurons and mnemonic judgment of objects

Cognitive neuroscience research on non-human primates demonstrated that judgments of whether humans have previously seen or not seen an object are causally determined by neuronal signals generated in the temporal cortex of the brain. The findings are published in Science (August 2017).

1 Sep 2017

Pioneering cancer gene therapy gets green light — and $475,000 price tag

The country's first approved gene therapy — approved Wednesday to fight leukemia that resists standard therapies — will cost $475,000 for a one-time treatment, its manufacturer announced.

30 Aug 2017

FDA approves first cell-based gene therapy for use in the United States

The U.S. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases.

30 Aug 2017

Research findings potentially open door to new treatments for eye trauma and retinal disease

Cells within an injured mouse eye can be coaxed into regenerating neurons and those new neurons appear to integrate themselves into the eye's circuitry, new research shows. The findings potentially open the door to new treatments for eye trauma and retinal disease.

28 Aug 2017

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Whenever an organism is damaged, the cells surrounding the wound receive signals to proliferate more intensely so as to regenerate the injured tissue.

26 Aug 2017

Increased enzyme production by the liver causes fatty liver, obesity and insulin resistance

In mice that are given a high-fat diet, an increased production of the enzyme DPP4 by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance.

24 Aug 2017

Long non-coding RNAs could represent novel male infertility drug targets

Scientists have found distinctive portions of genetic material--known as lncRNAs--that help sperm develop. Male mice lacking a particular lncRNA have low sperm count, suggesting lncRNAs could represent novel infertility drug targets.

24 Aug 2017

Research reveals underlying reason for intense pain in patients with shingles

Chickenpox is a typical childhood illness. In most cases, it is benign, and the symptoms disappear within ten days. However, its causative agent, Varicella zoster virus (VZV), remains in the organism forever. In some cases, the virus can be reactivated years later, causing a different disease known as herpes zoster, or shingles.

24 Aug 2017

Bacterial infections may trigger dysregulation of blood formation

It has been thought that only immune cells would act as the line of defense during bacterial infection. However, recent research has revealed that hematopoietic stem cells, cells that create all other blood cells throughout an individual's lifetime, are also able to respond to the infection.

24 Aug 2017

Id genes found to play crucial role in heart development

Researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP), the Cardiovascular Institute at Stanford University and other institutions were surprised to discover that the four genes in the Id family play a crucial role in heart development, telling undifferentiated stem cells to form heart tubes and eventually muscle.

22 Aug 2017

Stable vaccines using microscopic crystals from cypovirus

Scientists at Cell Guidance Systems, Cambridge University and Imperial College are exploiting microscopic crystals, made by a cypovirus, to produce stable vaccines for diseases that mostly affect the world's poorest people.

From Cell Guidance Systems 21 Aug 2017

Study explores effects of occupational, lifestyle risk factors on nurses' health

A prospective study of more than 20,000 nurses aged 20-45 years, 88% of whom had worked night shifts, reported their most common health issues, disease history, reproductive experiences, occupational exposures, and other lifestyle- and work-related factors.

17 Aug 2017

Genetic Engineering News and Research

New drug treatment linked to higher bladder compliance after spinal cord injury

Research shows new method for rapidly producing antimalarial drug at industrial scale

Novel compounds found to be highly effective in preventing transmission of malaria parasites

New DNA sequencing technology measures effects of thousands of sequences on gene activity

Research provides new insights into secret life of bacteria

Antibiotics may kill bacteria differently in vitro vs in vivo

Aberrant neural activity in lab mice presents potential challenges to study healthy brain

Mayo Clinic experts move closer to realizing clinical potential of senolytic drugs on aging

Researchers explore causal link between perirhinal neurons and mnemonic judgment of objects

Pioneering cancer gene therapy gets green light — and $475,000 price tag

FDA approves first cell-based gene therapy for use in the United States

Research findings potentially open door to new treatments for eye trauma and retinal disease

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Increased enzyme production by the liver causes fatty liver, obesity and insulin resistance

Long non-coding RNAs could represent novel male infertility drug targets

Research reveals underlying reason for intense pain in patients with shingles

Bacterial infections may trigger dysregulation of blood formation

Id genes found to play crucial role in heart development

Stable vaccines using microscopic crystals from cypovirus

Study explores effects of occupational, lifestyle risk factors on nurses' health

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