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RNA nanoparticles offer dual action against prostate tumors

Yang Zhang, PhD, and Jinjun Shi, PhD, both of the Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital, are co-senior authors of a paper published in ACS Nanoscience Au, "Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer."

10 Jan 2025

Aircraft noise pollution harms arteries, but heart drugs show promise in animal model research

Alpha- and beta-blockers reduce oxidative stress and inflammation caused by aircraft noise but fail to prevent hypertension, highlighting their potential to protect vascular health in noise-exposed individuals.

9 Jan 2025

Statistical model analyzes the cost-effectiveness of semaglutide for non-diabetic obese individuals

For overweight or obese individuals without diabetes, but with pre-existing cardiovascular disease, semaglutide (Ozempic, Wegovy) is not cost-effective at current pricing, new research shows.

9 Jan 2025

How stress fuels allergic skin inflammation

Researchers investigate the cellular and molecular mechanisms through which stress exacerbates immunoglobulin E cutaneous allergic inflammation.

9 Jan 2025

Gut microbes and the body work together to regulate fat metabolism

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce Thompson Institute at Cornell University's Ithaca campus.

9 Jan 2025

Unraveling the push-pull mechanism of neuron migration

The journey of a thousand miles begins with a single step, but for developing neurons, this first step relies on collaboration from multiple signaling pathways.

9 Jan 2025

Could camembert cheese hold the key to better memory?

Myristamide enhances cognitive function and BDNF in mice, indicating Camembert cheese's potential in combating cognitive decline and supporting brain health.

9 Jan 2025

Scientists uncover key factors for starting autophagy in cells

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.

8 Jan 2025

Study reveals how neuropilin2 gene influences autism and epilepsy development

The gene neuropilin2 encodes a receptor involved in cell-cell interactions in the brain and plays a key role in regulating the development of neural circuits.

8 Jan 2025

Age-related decline in cardiac conduction system regeneration increases arrhythmia risk after heart attack

Study uncovers the impact of myocardial infarction on the cardiac conduction system, revealing insights into arrhythmogenesis and potential therapeutic targets.

8 Jan 2025

Scientists discover new target for treating aggressive brain cancer

A study co-led by UCLA scientists has found targeting a protein called endocan and its related signaling pathway could be a promising new approach for treating glioblastoma, an aggressive and lethal type of brain cancer.

8 Jan 2025

Study finds microRNA target to combat breast cancer treatment resistance

A new University of Cincinnati Cancer Center study has identified a particular strand of microRNA as a promising new target for overcoming breast cancer treatment resistance and improving outcomes.

7 Jan 2025

Stress-induced immune dysfunction linked to worsened skin allergies

Psychological stress is known to exacerbate skin allergies, but the underlying molecular mechanisms remain poorly understood.

7 Jan 2025

Are individuals with advanced breast cancer more likely to have cardiovascular disease?

Research shows that patients with advanced breast cancer have higher odds of cardiovascular disease, emphasizing the importance of personalized screening.

7 Jan 2025

How loneliness and social isolation impact your health at the molecular level

This research identifies proteins linking social relationships to cardiovascular disease and mortality, offering insights for disease prediction and prevention.

7 Jan 2025

GLP-1 drugs linked to fewer post-surgical complications in diabetic patients

People with diabetes who were taking GLP-1 receptor agonist drugs such as tirzepatide and semaglutide had significantly lower rates of hospital readmission, wound re-opening and hematoma after surgery, according to a large study led by investigators at Weill Cornell Medicine, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian.

6 Jan 2025