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Online atlas created to identify, classify protein signatures present at AML diagnosis

Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis.

17 Apr 2019

Research sheds light on how leukemia cells become resistant to drugs

Three children Alejandro Gutierrez, MD, treated for leukemia during his fellowship at Boston Children's Hospital still haunt him more than a decade later.

17 Apr 2019

Microbiome science may help doctors to improve treatment for children with IBS

To improve the treatment of children with irritable bowel syndrome, investigators have developed a sophisticated way to analyze the microbial and metabolic contents of the gut.

17 Apr 2019

New study delves deeper into individual genomic differences than ever before

Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or "spelling mistakes" in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions and rearrangements of large segments of DNA.

17 Apr 2019

Study identifies novel loci contributing to asthma susceptibility in adults

A large, multi-ethnic genome-wide association study (GWAS) of asthma identified novel associations with potential relevance for asthma susceptibility in older adults of diverse racial backgrounds.

17 Apr 2019

Cancer cells grown in tumor-mimicking environment can help predict the effect of experimental drugs

Before being tested in animals or humans, most cancer drugs are evaluated in tumor cells grown in a lab dish.

17 Apr 2019

Study suggests new approach to treat renal fibrosis

Renal fibrosis, the abnormal accumulation of fibrotic material within the kidney, hinders kidney function and may lead to eventual renal failure.

16 Apr 2019

Framingham Heart Study receives $38 million for the next six years

The Framingham Heart Study, the nation's longest running cohort study with longitudinal analysis of cardiovascular disease, has been renewed for an additional six years and $38 million dollars from the National Heart, Lung, and Blood Institute.

16 Apr 2019

Novel serum biomarkers to detect NAFLD-related fibrosis

With an estimated 25% of people worldwide affected by nonalcoholic fatty liver disease (NAFLD), there is a large unmet need for accurate, noninvasive measures to enhance early diagnosis and screening of hepatic fibrosis.

16 Apr 2019

Yeast strain provides manufacturing boost to low-calorie sweetener derived from lactose

The quest to satisfy the sweet tooth without adding to the waistline has a new weapon in its arsenal: a strain of yeast that can metabolize lactose, the sugar in dairy products, into tagatose, a natural sweetener with less than half the calories of table sugar.

16 Apr 2019

Initial gene analysis could result in more effective antipsychotic treatment

An initial gene analysis may yield better outcomes when patients are treated with the antipsychotic drugs risperidone and aripiprazole.

16 Apr 2019

Researchers identify cause of inherited metabolic disorder

A new study from BC Children's Hospital, the University of British Columbia (UBC) and an international team of researchers published in the New England Journal of Medicine is the first to identify a rarely-seen type of DNA mutation as the cause of an inherited metabolic disorder.

16 Apr 2019

Study explores factors that impact fertility preservation decisions in transgender youth

The last thing on most teens' minds is whether or not they want to have kids someday. But transitioning transgender adolescents are forced to consider whether to preserve their sperm or eggs at a young age.

16 Apr 2019

Phenols in purple corn may fight obesity, inflammation and diabetes, mice study shows

Scientists at the University of Illinois have developed new hybrids of purple corn containing different combinations of phytochemicals that may fight obesity, inflammation and diabetes, a new study in mice indicates.

16 Apr 2019

CRISPR-scanning could lead to more effective treatments for cancer

11,000 people are predicted to die from acute myeloid leukemia in 2019, according to the American Cancer Society. The cancer starts in the bone marrow. There, mutated genes fail to prevent blood cells from replicating again and again and again, growing tumors.

16 Apr 2019

Scientists investigate processes that lead to neuronal death in ALS patients

Amyotrophic lateral sclerosis is an incurable disease of the central nervous system. In most cases, ALS is fatal within a short period following diagnosis.

15 Apr 2019

Researchers uncover cellular resistance mechanisms to BRAF inhibitors in melanoma

Melanoma is one of the most aggressive types of skin cancer, but recent advances in targeted therapies have improved the prognosis for many patients. Unfortunately, for some patients these positive outcomes are not long lasting, due to the development of drug resistance and tumor recurrence.

15 Apr 2019

Why have autism rates 'exploded' in New Jersey?

Researchers at Rutgers University have revealed that pre-schoolers in New Jersey have the highest rates of autism ever recorded in the US.

15 Apr 2019

Petting zoos can create a diverse reservoir of multidrug resistant bacteria

New research presented at this year's European Congress of Clinical Microbiology & Infectious Diseases in Amsterdam, Netherlands shows that petting zoos can create a diverse reservoir of multidrug resistant bacteria, which could lead to highly virulent drug-resistant pathogens being passed on to visitors.

15 Apr 2019

Cancer cells use tactics to avoid being recognised by immunotherapy agents

Researchers have found that bowel cancer cells have a mechanism by which they can switch off some key molecules on their surfaces and thus escape being recognised and killed by the immunotherapy agents.

15 Apr 2019