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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

New tumor-penetrating therapy may improve outcomes in patients with pancreatic cancer

Every 12 minutes, someone in the United States dies of pancreatic cancer, which is often diagnosed late, spreads rapidly and has a five-year survival rate at approximately 10 percent.

9 Mar 2021

SARS-CoV-2 variants rapidly arise in non-human hosts, potential risk for human reinfection

The study, published on the preprint server bioRxiv*, highlights the need to study viral evolution and pathogenesis in human and animal hosts. This could help prevent future outbreaks that may mimic the magnitude of the current COVID-19 pandemic.

9 Mar 2021

Scientists study seven human coronavirus envelope proteins using topology prediction and molecular modeling

A new study by researchers at the University of the Western Cape aimed to determine why some coronaviruses are more virulent than others. The team speculates that the increased flexibility of the PDZ-binding motif (PBM) of SARS-CoV, MERS-CoV, and SARS22 CoV-2 to be more flexible than the PBM of hCoVs 229E, NL63, OC43, and HKU1.

9 Mar 2021

First complete atlas of how mutations affect the formation of amyloid plaques in Alzheimer’s disease

A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer's disease.

9 Mar 2021

Vaccine mRNA not found in breast milk after COVID mRNA vaccination

A study conducted by researchers in the United States has found no evidence to suggest that the messenger RNA (mRNA) present in the Pfizer-BioNTech and Moderna vaccines that protect against coronavirus disease 2019 (COVID-19) can be transferred to human breast milk.

9 Mar 2021

Phase 2 clinical trial is now open at Columbia to test gene therapy for dry macular degeneration

A phase 2 clinical trial is underway at Columbia University and NewYork-Presbyterian to test an investigational gene therapy for dry age-related macular degeneration, a progressive, chronic eye disease with no cure and a leading cause of blindness in the United States.

9 Mar 2021

Somatic gene mutations in brain cells could contribute to schizophrenia pathology

Schizophrenia is a neurodevelopmental disorder that disrupts brain activity producing hallucinations, delusions, and other cognitive disturbances. Researchers have long searched for genetic influences in the disease, but genetic mutations have been identified in only a small fraction--fewer than a quarter--of sequenced patients.

9 Mar 2021

Study describes the infection of human cells by intestinal pathogen during spaceflight

Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems.

9 Mar 2021

Buck scientists develop a predictive model to help identify people at risk for severe COVID-19

Researchers at the Buck Institute analyzed data from the COVID-19 Symptom Tracker app used by 3 million people in the United Kingdom, adding the use of immunosuppressant medication, use of a mobility aid, shortness of breath, fever, and fatigue to the list of symptoms and comorbidities that increase the risk for severe COVID-19.

9 Mar 2021

Human cerebral organoid model to screen drugs for treatment of Creutzfeldt-Jakob disease

Approximately two years after establishing a human cerebral organoid system to study Creutzfeldt-Jakob disease (CJD), National Institutes of Health researchers have further developed the model to screen drugs for potential CJD treatment.

9 Mar 2021

Study uncovers mechanism to help explain how maternal stress causes idiopathic preterm birth

Preterm birth is a leading cause of infant deaths and illness in the U.S. -- yet its underlying molecular causes remain largely unclear. About 40 to 50% of preterm births, defined as births before 37 weeks of pregnancy, are estimated to be "idiopathic," meaning they arise from unexplained or spontaneous labor.

9 Mar 2021

CBD ameliorates cognitive function in experimental model of familial Alzheimer's

A two-week course of high doses of CBD helps restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer's disease, and improves cognition in an experimental model of early onset familial Alzheimer's, investigators report.

9 Mar 2021

A genetic variant of TMPRSS2 may confer protection against severe COVID-19

Among a large sample of COVID-19 patients, researchers found that a genetic variant – caused by an amino acid substitution from valine to methionine – is associated with a reduced chance of severe disease.

9 Mar 2021

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans

In a recent report made available on bioRxiv* preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process.

9 Mar 2021

SARS-CoV-2's amyloid-driving nucleoprotein could inform future therapeutic research

New research led by researchers at the University of California Los Angeles and the University of Texas Southwestern Medical Center in the US suggests that functional amyloid fibrils could play an integral role in developing COVID-19 treatments.

9 Mar 2021

Greater cross-neutralization against UK SARS-CoV-2 variant in vaccinated individuals with prior infection

A team of researchers in Spain has observed that, of those who have been vaccinated against SARS-CoV-2, higher titers of neutralizing antibodies for the B.1.1.7 variant (originating in the UK) were present in those who had previously been infected with the virus.

9 Mar 2021

Scientists develop RNA-based therapeutic strategy for Charcot-Marie Tooth disease

Charcot-Marie Tooth disease is the most common hereditary neurological disease in the world. It affects the peripheral nerves and causes progressive paralysis of the legs and hands.

9 Mar 2021

Proteomics shows SARS-CoV-2 NSP7 and NSP8 forms stable dimeric unit

A new preprint, released on the bioRxiv* preprint server, describes the structure of part of the dynamic protein-RNA complex known as the replication-transcription complex (RTC), which is crucial in the replication of the large ribonucleic acid (RNA) genome of this virus.

9 Mar 2021

Ultraviolet light therapy reduces viral load in critically ill COVID-19 patients

Scientists from the United States has recently evaluated the safety and efficacy profiles of ultraviolet-A (UVA) light applied via an endotracheal tube to critically ill COVID-19 patients.

9 Mar 2021

Bruker announces new results in deep, unbiased plasma proteomics, PaSER 1.1 software and new cross-linking consumables at US HUPO 2021

At the virtual 17th US HUPO Conference (US HUPO 2021), Bruker Corporation (Nasdaq: BRKR) today announces progress with several collaborations in deep, unbiased plasma proteomics, leveraging the speed, sensitivity and dynamic range of 4D proteomics on timsTOF Pro systems.

From Bruker Daltonics 9 Mar 2021

Protein News and Research

Further Reading

New tumor-penetrating therapy may improve outcomes in patients with pancreatic cancer

SARS-CoV-2 variants rapidly arise in non-human hosts, potential risk for human reinfection

Scientists study seven human coronavirus envelope proteins using topology prediction and molecular modeling

First complete atlas of how mutations affect the formation of amyloid plaques in Alzheimer’s disease

Vaccine mRNA not found in breast milk after COVID mRNA vaccination

Phase 2 clinical trial is now open at Columbia to test gene therapy for dry macular degeneration

Somatic gene mutations in brain cells could contribute to schizophrenia pathology

Study describes the infection of human cells by intestinal pathogen during spaceflight

Buck scientists develop a predictive model to help identify people at risk for severe COVID-19

Human cerebral organoid model to screen drugs for treatment of Creutzfeldt-Jakob disease

Study uncovers mechanism to help explain how maternal stress causes idiopathic preterm birth

CBD ameliorates cognitive function in experimental model of familial Alzheimer's

A genetic variant of TMPRSS2 may confer protection against severe COVID-19

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans

SARS-CoV-2's amyloid-driving nucleoprotein could inform future therapeutic research

Greater cross-neutralization against UK SARS-CoV-2 variant in vaccinated individuals with prior infection

Scientists develop RNA-based therapeutic strategy for Charcot-Marie Tooth disease

Proteomics shows SARS-CoV-2 NSP7 and NSP8 forms stable dimeric unit

Ultraviolet light therapy reduces viral load in critically ill COVID-19 patients

Bruker announces new results in deep, unbiased plasma proteomics, PaSER 1.1 software and new cross-linking consumables at US HUPO 2021

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