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Thousands got Exactech knee or hip replacements. Then, patients say, the parts began to fail.

Ron Irby expected the artificial knee implanted in his right leg in September 2018 would last two decades — perhaps longer.

10 Oct 2023

1918 flu's true victims were not the fittest, but the most stressed

Analyzing remains of 1918 influenza pandemic victims, researchers from McMaster University and the University of Colorado Boulder found that the flu's most susceptible victims showed signs of prior environmental, nutritional, and social stress. Contrary to historical beliefs, the study, published in PNAS, revealed that those in poor health were more likely to succumb to the pandemic than healthy individuals.

9 Oct 2023

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

In a study published in the journal Genes & Diseases, researchers from Army Medical University and Shenzhen University investigated the pivotal role of miR-18a-5p, a microRNA, in the development and progression of osteoblastic lesions resulting from prostate cancer (PCa) bone metastasis.

9 Oct 2023

Diverse diets for stronger bones: Study reveals how alternative eating habits prevent osteoporosis

The study examines how various dietary patterns, beyond the Mediterranean diet, influence osteoporosis and fracture risk in older adults, emphasizing the importance of both diet and exercise in bone health. Regional diets, exercise, and consistent research methodologies are critical for comprehensive osteoporosis prevention guidelines.

8 Oct 2023

Genetic markers could help women with rheumatoid arthritis make informed decisions about pregnancy

When women with rheumatoid arthritis (RA) plan to become pregnant, many anguish over whether to stop their medications, risking a flareup in their disease, or continue with medication and risk possible harm to the baby.

6 Oct 2023

The metabolic effects of endocrine therapy on diabetes mellitus in breast cancer survivors

Researchers discuss the history of endocrine therapies, highlights their adverse metabolic effects, and emphasizes the need for better biomarkers of diabetes.

5 Oct 2023

How vitamin D and genetics shape early brain development

The study examined how vitamin D levels and vitamin D binding protein genotypes in both pregnant mothers and their children aged 3-5, impact early childhood neurodevelopment. Findings suggest that higher vitamin D concentrations in children were associated with better neurodevelopmental scores, with additional influences from sociodemographic factors and certain genetic variations.

4 Oct 2023

Oral lipid nanoparticle drug shows promise for preventing colitis-associated cancer in mice

An oral lipid nanoparticle drug prevents tumor development in mice, suggesting this is a promising drug formulation for preventing colitis-associated cancer, according to a study led by researchers in the Institute for Biomedical Sciences at Georgia State University.

4 Oct 2023

Weill Cornell Medicine researcher receives $610,000 grant to study metastasis in bladder cancer

A Weill Cornell Medicine researcher has received a $610,000 grant from the Department of Defense to investigate the mechanisms causing DNA instability that potentially drives metastasis in bladder cancer.

4 Oct 2023

Applied Cells opens CellQuest Research Grant to accelerate cutting-edge multiple myeloma research

Applied Cells is thrilled to announce the opening of the CellQuestGrant.

From Applied Cells 2 Oct 2023

Study reveals new insights into how the immune system prevents autoimmunity

Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body's own, healthy tissues.

29 Sep 2023

Racial disparities in survival rates among patients with multiple myeloma and diabetes

Patients with multiple myeloma, a blood cancer of plasma cells in the bone marrow, who also have diabetes have a reduced overall survival when compared to those without diabetes.

29 Sep 2023

Parasites that cause visceral leishmaniasis can infect non-immune cells, study finds

The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.

29 Sep 2023

Study uncovers previously unknown compensatory mechanism in liver disease

A team of researchers has uncovered a previously unknown compensatory mechanism found in liver disease.

28 Sep 2023

Evolution of new technologies to better diagnose bone fragility

Dual energy x-ray absorptiometry (DXA) is the gold standard for assessing bone mass and evaluating fracture risk.

27 Sep 2023

Blocking Notch signaling pathway could reverse age-related bone loss

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice.

27 Sep 2023

Prolonged mismatch between calories eaten and burned may be putting many athletes at risk of REDs

The estimated prevalence of REDs varies by sport, ranging from 15% to 80%. The syndrome often goes unrecognised by athletes themselves, their coaches, and team clinicians, and may unwittingly be exacerbated by the 'sports culture,' because of the perceived short term gains on performance from intentionally or unintentionally limiting calorie intake, warns the Statement.

26 Sep 2023

Stem cell transplant offers hope for patients with multiple sclerosis

Stem cells harvested from a person's own bone marrow or blood, can safely slow progression of the most common form of the autoimmune disease, multiple sclerosis, or MS as it's usually known, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

26 Sep 2023

Stem cell transplant offers hope for MS patients, study finds

Autologous hematopoietic stem cell transplantation, or aHSCT for short, is usually used to treat blood cancers, and involves harvesting stem cells from the person's own bone marrow or blood followed by chemotherapy and antibody treatment.

25 Sep 2023

Certain gut microbes may be linked to skeletal health

There is growing evidence that a relative abundance of certain gut microbes may be related to skeletal health, according to a new study published in Frontiers in Endocrinology.

22 Sep 2023

Bone News and Research

Thousands got Exactech knee or hip replacements. Then, patients say, the parts began to fail.

1918 flu's true victims were not the fittest, but the most stressed

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

Diverse diets for stronger bones: Study reveals how alternative eating habits prevent osteoporosis

Genetic markers could help women with rheumatoid arthritis make informed decisions about pregnancy

The metabolic effects of endocrine therapy on diabetes mellitus in breast cancer survivors

How vitamin D and genetics shape early brain development

Oral lipid nanoparticle drug shows promise for preventing colitis-associated cancer in mice

Weill Cornell Medicine researcher receives $610,000 grant to study metastasis in bladder cancer

Applied Cells opens CellQuest Research Grant to accelerate cutting-edge multiple myeloma research

Study reveals new insights into how the immune system prevents autoimmunity

Racial disparities in survival rates among patients with multiple myeloma and diabetes

Parasites that cause visceral leishmaniasis can infect non-immune cells, study finds

Study uncovers previously unknown compensatory mechanism in liver disease

Evolution of new technologies to better diagnose bone fragility

Blocking Notch signaling pathway could reverse age-related bone loss

Prolonged mismatch between calories eaten and burned may be putting many athletes at risk of REDs

Stem cell transplant offers hope for patients with multiple sclerosis

Stem cell transplant offers hope for MS patients, study finds

Certain gut microbes may be linked to skeletal health

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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