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Farnesyl transferase inhibitors may help chidren with Hutchinson-Gilford progeria syndrome

Johns Hopkins scientists have discovered that a drug currently being tested against cancers might help children with a rare, fatal condition called Hutchinson-Gilford progeria syndrome, which causes rapid, premature aging.

27 Sep 2005

Plans to develop a "universal beta-cell line" - treatment for type 1 diabetes

Transplantation of insulin-producing pancreatic beta-cells shows great promise as a treatment for type 1 diabetes, but development of this therapy has been hampered by a severe shortage of donor beta-cells, which are obtained from decreased human donors.

26 Sep 2005

Human embryonic stem cell lines accumulate changes in their genetic material over time

The findings do not limit the utility of the cells for some types of research or for some future clinical applications, the researchers say, but draw attention to the need to closely monitor stem cell lines for genetic changes and to study how these alterations affect the cells' behavior.

6 Sep 2005

Human embryonic stem cell lines accumulate changes in their genetic material over time

5 Sep 2005

Prostate cancer manipulates an important group of signaling proteins called Wnts to establish itself in bone

Prostate cancer is a cruel disease. Left untreated, prostate cancer cells often metastasize, or spread, to bone where they form fracture-prone tumors that are extremely painful.

1 Sep 2005

New technique for creating human embryonic stem cells

Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells.

22 Aug 2005

Researchers have identified a pathway that is specific for cancer

When cancer spreads, people often die. That's why a lot of cancer research and drugs focus on the metabolic pathways that allow cancer to metastasize -- to spread from one part of the body to another.

1 Aug 2005

Experimental treatment shown to reverse the loss of nerve fibres in Parkinson's Disease

Analysis of the brain of a patient suffering from Parkinson's Disease has shown that the experimental treatment he received caused regrowth of the nerve fibres that are lost in this disease. The findings are reported in the July issue of Nature Medicine.

6 Jul 2005

Experimental treatment regrows nerve fibres in patient suffering Parkinson's disease

Analysis of the brain of a patient suffering from Parkinson’s Disease has shown that the experimental treatment he received caused regrowth of the nerve fibres that are lost in this disease. The findings are reported in the July issue of Nature Medicine.

30 Jun 2005

Omega-3 combined with propofol may lead to new drugs to treat breast cancer

Omega-3, the fatty acid found in oily fish, could be combined with a commonly used anesthetic to develop drugs to treat breast cancer, according to research published in the journal Breast Cancer Research.

8 Jun 2005

Researchers generate patient-specific stem cells

Researchers have isolated the first human embryonic stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various ages, suffering from disease or spinal cord injury.

20 May 2005

Premature use of stem cell therapy could put patients at risk

The premature use of stem cell therapy could put many patients at risk of viral or prion diseases unless appropriate safety systems are in place, warn experts in this week’s BMJ.

19 May 2005

Black cohosh may interfere with breast cancer drugs

Black cohosh, an herb widely used by breast cancer patients to alleviate hot flashes and other menopausal symptoms, may alter the way that cells respond to drugs commonly used to treat breast cancer, according to a Yale School of Medicine study in Breast Cancer Research and Treatment.

27 Apr 2005

Guidelines for research involving human embryonic stem cells

The National Academies today recommended guidelines for research involving human embryonic stem cells, and urged all institutions conducting such research to establish oversight committees to ensure that the new guidelines will be followed.

26 Apr 2005

New strategy to identify differences between non-metastatic and highly metastatic breast cancer cells

Researchers at the University of California, San Diego have used a new strategy to identify differences between non-metastatic and highly metastatic breast cancer cells. The article by Valerie Montel et al., "Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model," appears in the May 2005 issue of The American Journal of Pathology and is accompanied by a commentary.

22 Apr 2005

RNA interference permanently silences key breast cancer gene

In laboratory mouse experiments, researchers at The University of Texas M. D. Anderson Cancer Center have developed a way to use RNA interference (RNAi) so that it permanently hampers breast cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human breast tumors, thus reducing the cancer's ability to become invasive.

20 Apr 2005

Reducing expression of a gene called BRCC36 makes breast cancer cells more responsive to ionizing radiation

The research was presented today at the 96th Annual Meeting of the American Association for Cancer Research (AACR) in Anaheim, Calif. BRCC36 directly interacts with the BRCA1 protein. Almost all invasive breast cancer cells have elevated BRCC36 levels compared to normal breast milk-duct cells.

20 Apr 2005

Researchers insert engineered human stem cells into the spinal cords of ALS-afflicted rats

Unveiling a delivery method that may one day help surgeons treat the deadly neurodegenerative disease amyotrophic lateral sclerosis (ALS), researchers at the University of Wisconsin-Madison have inserted engineered human stem cells into the spinal cords of ALS-afflicted rats.

19 Apr 2005

Strawberries destroy cancer cells

Researchers specializing in the health benefits of plant compounds have shown that quercetin, a phytonutrient found in abundance in strawberries and other fruits, can induce programmed self-destruction of human cancer cells.

23 Mar 2005

UK grows stem cells free of animal products

Dr Paul de Souza and scientists at the Roslin Institute have successfully created human cells without using animal products.

17 Mar 2005

Cell Line News and Research

Farnesyl transferase inhibitors may help chidren with Hutchinson-Gilford progeria syndrome

Plans to develop a "universal beta-cell line" - treatment for type 1 diabetes

Human embryonic stem cell lines accumulate changes in their genetic material over time

Human embryonic stem cell lines accumulate changes in their genetic material over time

Prostate cancer manipulates an important group of signaling proteins called Wnts to establish itself in bone

New technique for creating human embryonic stem cells

Researchers have identified a pathway that is specific for cancer

Experimental treatment shown to reverse the loss of nerve fibres in Parkinson's Disease

Experimental treatment regrows nerve fibres in patient suffering Parkinson's disease

Omega-3 combined with propofol may lead to new drugs to treat breast cancer

Researchers generate patient-specific stem cells

Premature use of stem cell therapy could put patients at risk

Black cohosh may interfere with breast cancer drugs

Guidelines for research involving human embryonic stem cells

New strategy to identify differences between non-metastatic and highly metastatic breast cancer cells

RNA interference permanently silences key breast cancer gene

Reducing expression of a gene called BRCC36 makes breast cancer cells more responsive to ionizing radiation

Researchers insert engineered human stem cells into the spinal cords of ALS-afflicted rats

Strawberries destroy cancer cells

UK grows stem cells free of animal products

Optimizing cell line development for recombinant proteins and monoclonal antibodies eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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