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Open multiplexing with Cell DIVE offers cancer researchers more choices

Leica has introduced a new generation of its multiplexed imaging solution, Cell DIVE, including software and hardware improvements. The more scalable and efficient multiplexing platform addresses spatial cell biology and function within the tissue microenvironment

From Leica Microsystems GmbH 8 Jun 2022

Study identifies an epigenetic regulator that suppresses pathogenic events in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by chronic inflammation of synovium, eventually leading to joint destruction. Epigenetic alteration (the mechanism of gene expression regulation without DNA sequence changes), such as low levels of DNA methylation, is one of the factors which worsens the RA state.

8 Jun 2022

Axol Bioscience introduces CiPA-validated human stem cell-derived ventricular cardiomyocytes to help improve drug discovery

Axol Bioscience Ltd. (Axol), an established provider of iPSC-derived cells, media, and characterization services for life science discovery, today announced that its human induced pluripotent stem cell (iPSC)-derived ventricular cardiomyocytes have undergone comprehensive in vitro pro-arrhythmia assay (CiPA) validation.

From Axol Bioscience Ltd 8 Jun 2022

Molecular modeling techniques describe the process of interaction between nanotubes and the main structures of SARS-CoV-2

Researchers assessed the interactions between carbon nanotubes and SARS-CoV-2.

7 Jun 2022

Novel approach identifies potent drug-like molecules that bind to cancer protein of interest

Researchers at Baylor College of Medicine and Texas Children's Hospital have identified potent, highly specific compounds that interfere with bromodomain (BD)-containing proteins involved in cancer.

3 Jun 2022

New method to combat malaria turns the disease against itself

A new method to combat malaria which sees the disease turn against itself could offer an effective treatment for the hundreds of millions of people infected globally each year, as the efficacy of current antimalarial drugs weakens.

3 Jun 2022

Marine organism compounds may have potential to help human fertility

Zinc-filled oysters are often linked to improved libido and sexual activity, and now scientists at Flinders University are calling for more serious investigations into how marine organism compounds can help human fertility.

3 Jun 2022

Millions of COVID-19 patients may have undiagnosed acute kidney injury, finds study

A University of Queensland-led study has found millions of COVID-19 patients may have undiagnosed acute kidney injury (AKI).

2 Jun 2022

New compound shows promise to kill a range of hard-to-treat cancer types

A compound, developed by a team including scientists from The University of Texas Health Science Center at San Antonio, kills a range of hard-to-treat cancer types in petri dishes and animal models by targeting a previously unexploited vulnerability, a new study reports.

2 Jun 2022

Researchers identify chemical compound that may short-circuit brain cell death in Parkinson's disease

In studies in mice, Johns Hopkins Medicine researchers say they have identified a chemical compound that stops the final events in the pathway linked to the death of brain cells in Parkinson's disease.

1 Jun 2022

New compounds for cancer immunotherapy via STING-mediated immune activation

Innovations in cancer immunotherapy have achieved clinical success by considerably increasing the survival rate of patients undergoing cancer treatment.

31 May 2022

Innovative solutions to the challenges of narcotic analysis

In this interview, Dr. Joerg Koehler and Dr. Marcio-Fernando Cobo from Bruker introduce their forensic distributed lab topology featuring the Fourier 80 CrimeLab with NMR-based narcotics profiling module.

From Bruker BioSpin Division 30 May 2022

Researchers discover bifunctional lipopeptide antibiotic with a low resistance potential

Through bioinformatic prospecting, researchers discovered and synthesized a novel, naturally inspired bifunctional lipopeptide antibiotic with a low resistance potential.

27 May 2022

Scientists unlock a new approach to kill hard-to-treat cancers

In a paper appearing in Nature today, an international group of scientists have unlocked a new way to kill hard to treat cancers. These tumors resist current immunotherapies, including those using Nobel Prize winning check-point blocking antibodies.

26 May 2022

Case Western Reserve signs license agreement to bring groundbreaking AI for helping cancer patients

When Case Western Reserve University research showed that artificial intelligence (AI) could identify which lung cancer patients would benefit from chemotherapy, a national magazine called the finding one of the "10 Most Incredible Medical Breakthroughs of 2018."

25 May 2022

Insilico Medicine nominates novel preclinical candidate targeting 3CL protease for COVID-19 treatment

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced its nomination of a novel preclinical candidate (PCC) targeting 3C-like (3CL) protease for the treatment of COVID-19.

24 May 2022

Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study

A new paper presents the results of a mouse study using the repurposed antibacterial drug clofoctol against this virus.

23 May 2022

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5.

20 May 2022

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

A new study has revealed that ATV006, which is a 5′-hydroxyl-isobutyryl prodrug, possesses extraordinary oral pharmaco-kinetic (PK) profiles in rats and cynomolgus monkeys and exhibited significant antiviral activity against ancestral SARS-COV-2 strain as well as VOCs.

20 May 2022

Insight into sustained-release drug delivery systems

In this interview, News-Medical speaks to Thanh T. Nguyen, a project manager at Innocore Pharmaceuticals, about the mechanisms behind long-acting injectables.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 18 May 2022

Compound News and Research

Open multiplexing with Cell DIVE offers cancer researchers more choices

Study identifies an epigenetic regulator that suppresses pathogenic events in rheumatoid arthritis

Axol Bioscience introduces CiPA-validated human stem cell-derived ventricular cardiomyocytes to help improve drug discovery

Molecular modeling techniques describe the process of interaction between nanotubes and the main structures of SARS-CoV-2

Novel approach identifies potent drug-like molecules that bind to cancer protein of interest

New method to combat malaria turns the disease against itself

Marine organism compounds may have potential to help human fertility

Millions of COVID-19 patients may have undiagnosed acute kidney injury, finds study

New compound shows promise to kill a range of hard-to-treat cancer types

Researchers identify chemical compound that may short-circuit brain cell death in Parkinson's disease

New compounds for cancer immunotherapy via STING-mediated immune activation

Innovative solutions to the challenges of narcotic analysis

Researchers discover bifunctional lipopeptide antibiotic with a low resistance potential

Scientists unlock a new approach to kill hard-to-treat cancers

Case Western Reserve signs license agreement to bring groundbreaking AI for helping cancer patients

Insilico Medicine nominates novel preclinical candidate targeting 3CL protease for COVID-19 treatment

Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

Insight into sustained-release drug delivery systems

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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