Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

New research identifies critical function of PDK1 pathway that contributes to cancer metastasis

Cancer is most devastating when it metastasizes--when tumor cells break away, travel through the bloodstream, and then attach elsewhere, only to grow another tumor.

8 May 2018

Cancer scientists confirm oligometastasis hypothesis

In 1995, two University of Chicago-based cancer specialists suggested there was an intermediate state - somewhere between curable localized cancers and lethal widespread disease - for patients with metastatic cancer.

7 May 2018

New data supports clinical use of DecisionDx-Melanoma test to inform SLNB options

Castle Biosciences, Inc., the skin cancer diagnostics company providing molecular diagnostics to improve cancer treatment decisions, today announced the presentation of data supporting clinical use of the DecisionDx®-Melanoma test to inform sentinel lymph node biopsy (SLNB) recommendations.

7 May 2018

Researchers uncover protein linked to breast cancer metastasis

Jean-François Côté, a researcher at the Montreal Clinical Research Institute and professor at Université de Montréal's Faculty of Medicine, studies metastasis, the leading cause of cancer-related death. Recently, his team uncovered a protein that, once deactivated, could prevent the development of metastases in an aggressive type of cancer, HER2-positive breast cancer.

7 May 2018

Penn State professor receives NSF CAREER award to study mechanobiology of cell differentiation

Esther Gomez, assistant professor of chemical engineering and biomedical engineering, Penn State, has received the National Science Foundation's prestigious Early Career award to better understand the mechanobiology of mesenchymal-epithelial transition.

4 May 2018

Stiff tissue can present microenvironment susceptible to tumor growth, says study

Stiffer breast tissue creates an environment more prone to cancer by enabling the disease to interfere with the surrounding healthy cells, according to a recent study published in Biomaterials.

4 May 2018

Osteoporosis drug prevents spread of basal-like breast cancer in mice

Researchers in China have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, an aggressive form of the disease that is largely untreatable.

4 May 2018

Non-aspirin NSAID use linked to shorter survival in patients with metastatic renal cell carcinoma

Ibuprofen, aspirin, and other non-steroidal anti-inflammatory medications are among the most commonly utilized medications in the United States. Primarily for treating pain, inflammation, and preventing cardiovascular disease, NSAIDs' promising anti-cancer properties have been highlighted by a growing body of data in recent years.

2 May 2018

Direct contact with lymphatic endothelial cells promotes melanoma metastasis

Despite the declining death rates for many individual cancer types, mortality for a few cancers has stabilized or even increased. One of these is melanoma due to its ability, in later stages, to spread to other parts of the body.

2 May 2018

Study explains how colon cancer cells spread to the liver

Colorectal cancer is the third most common cancer worldwide and the third-leading cause of cancer-related deaths. The main cause of death in patients with colorectal cancer is liver metastasis, with nearly 70% of patients eventually developing a liver tumor.

25 Apr 2018

Studies provide advanced knowledge about renal cancer

Cell, the most prestigious international journal in the field of biology, is today publishing a set of three papers on renal cancer. Among the authors of these papers is Dr José Ignacio López, head of the Pathological Anatomy Service of University Hospital Cruces and tenured lecturer in Pathological Anatomy at the UPV/EHU's Faculty of Medicine and Nursing.

24 Apr 2018

Scientists develop tissue-engineered models to better understand cancer metastases

Cancer that has spread, or metastasized, from its original site to other tissues and organs in the body is a leading cause of cancer death.

24 Apr 2018

Studies show hemp's potential for treating ovarian cancer

Results from some of the first studies to examine hemp's ability to fight cancer show that it might one day be useful as plant-based treatment for ovarian cancer. Hemp is part of the same cannabis family as marijuana but doesn't have any psychoactive properties or cause addiction.

24 Apr 2018

Innovative research could lead to new ways to treat, prevent cancer

Research into cancer can provide new insight into how this disease works and how it can be stopped. The Experimental Biology 2018 meeting will showcase innovative research that could lead to new ways to treat and prevent cancer.

23 Apr 2018

Innovative device shows promise in capturing and releasing circulating tumor cells

For years, bioengineer Yaling Liu has been in pursuit of the deadly tumor cell. Liu has been perfecting a microfluidic device the size of two quarters that has the ability to catch and release circulating tumor cells (CTCs)--cancer cells that circulate in a cancer patient's blood.

19 Apr 2018

Roswell Park researchers identify driver of cancer-promoting metabolic changes

Roswell Park Comprehensive Cancer Center researchers have identified a potential key player promoting cancer progression through changes in the cell environment that are conducive to metastasis.

17 Apr 2018

Axillary ultrasound imaging found to be inferior for detecting lymph node metastases in breast cancer

For patients diagnosed with breast cancer, determining whether cancer cells have spread to the axillary lymph nodes of the armpit is important for guiding treatment decisions. It has been debated whether axillary ultrasound imaging is equally sensitive for detecting axillary metastatic lymph nodes in different subtypes of breast cancer.

17 Apr 2018

Research reveals immune suppressive role of soluble antibodies in tumor progression

Wistar researchers have found that soluble antibodies promote tumor progression by inducing accumulation of myeloid-derived suppressor cells (MDSCs) in pre-clinical cancer models. Results were published online in Cancer Immunology Research.

13 Apr 2018

Researchers discover key enzyme driving breast cancer

Looking to identify new strategies to prevent breast cancer recurrence, a research team led by Subhamoy Dasgupta, PhD, Assistant Professor of Oncology in the Department of Cell Stress Biology at Roswell Park Comprehensive Cancer Center, has identified two key proteins involved in glucose metabolism that could be targeted to prevent breast cancer metastasis and recurrence. The team's findings were published today in the journal Nature.

11 Apr 2018

Removal of single mitochondrial protein leads to severe inflammation

The link between mitochondria and inflammation is still unclear. But it is known is that, for example, the accumulation of defective mitochondria, which should have been removed, causes inflammation.

10 Apr 2018

Metastasis News and Research

Further Reading

New research identifies critical function of PDK1 pathway that contributes to cancer metastasis

Cancer scientists confirm oligometastasis hypothesis

New data supports clinical use of DecisionDx-Melanoma test to inform SLNB options

Researchers uncover protein linked to breast cancer metastasis

Penn State professor receives NSF CAREER award to study mechanobiology of cell differentiation

Stiff tissue can present microenvironment susceptible to tumor growth, says study

Osteoporosis drug prevents spread of basal-like breast cancer in mice

Non-aspirin NSAID use linked to shorter survival in patients with metastatic renal cell carcinoma

Direct contact with lymphatic endothelial cells promotes melanoma metastasis

Study explains how colon cancer cells spread to the liver

Studies provide advanced knowledge about renal cancer

Scientists develop tissue-engineered models to better understand cancer metastases

Studies show hemp's potential for treating ovarian cancer

Innovative research could lead to new ways to treat, prevent cancer

Innovative device shows promise in capturing and releasing circulating tumor cells

Roswell Park researchers identify driver of cancer-promoting metabolic changes

Axillary ultrasound imaging found to be inferior for detecting lymph node metastases in breast cancer

Research reveals immune suppressive role of soluble antibodies in tumor progression

Researchers discover key enzyme driving breast cancer

Removal of single mitochondrial protein leads to severe inflammation

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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