Signaling Pathway News and Research

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Biologists identify signaling pathway that switches on calorie-burning process in brown fat cells

Biologists at The Scripps Research Institute (TSRI) have identified a signaling pathway that switches on a powerful calorie-burning process in brown fat cells.

1 Aug 2014

Signaling pathway key player in formation of front-most portion of developing vertebrate embryos

A signaling pathway once thought to have little if any role during embryogenesis is a key player in the formation of the front-most portion of developing vertebrate embryos.

18 Jul 2014

TAZ represents a novel therapeutic target in NSCLC

Patients with non-small-cell lung cancer who express high levels of transcriptional coactivator with PDZ-binding motif may be a clinically distinct subgroup with an unfavourable prognosis, researchers report.

16 Jul 2014

New role for cholesterol in activation of cellular signaling pathway that linked to cancer

Everyone knows that cholesterol, at least the bad kind, can cause heart disease and hardening of the arteries. Now, researchers at the University of Illinois at Chicago describe a new role for cholesterol in the activation of a cellular signaling pathway that has been linked to cancer.

15 Jul 2014

Scientists develop RNA that binds cGMP

The transmission of signals within cells is dependent on cyclic guanosine monophosphate (cGMP) as an important secondary messenger. German scientists have now developed an RNA that binds cGMP. As reported in the journal Angewandte Chemie, it is possible to suppress the cGMP signal cascade in genetically modified cells that produce this RNA.

10 Jul 2014

New knowledge may expand treatments for patients with lung cancer

Studying the most common type of lung cancer, researchers have uncovered mutations in a cell-signaling pathway that plays a role in forming tumors.

10 Jul 2014

TCGA finds novel mutations in key cancer-causing pathway in lung adenocarcinoma

Researchers from The Cancer Genome Atlas Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer.

10 Jul 2014

Small antioxidant molecules suppress colon cancer associated with colitis

Researchers from Case Western Reserve and Dartmouth universities have shown that a class of small antioxidant molecules carries enormous promise for supressing colon cancer associated with colitis.

25 Jun 2014

Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.

18 Jun 2014

Signaling pathway may help explain why body clocks of people with bipolar disease

Alterations in a cellular signaling pathway called cAMP-CREB may help explain why the body clocks of people with bipolar disease are out of sync, according to a new European Journal of Neuroscience study.

17 Jun 2014

Researchers uncover several gene networks with potentially important roles in autism

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism.

9 Jun 2014

Gene networks may offer attractive targets for developing new autism drugs

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism.

6 Jun 2014

Regeneration of a chronically diseased liver may be possible, say Harvard researchers

Harvard Stem Cell Institute scientists at Boston Children's Hospital have new evidence in mice that it may be possible to repair a chronically diseased liver by forcing mature liver cells to revert back to a stem cell-like state.

6 Jun 2014

New study of how biodiversity arises

A new study of how biodiversity arises, by evolutionary biologists at the University of Massachusetts Amherst, shows how a mutation in a single gene during development can lead to different consequences not only in how animals' skull and jaw are shaped, but how this leads to different feeding strategies to exploit different ecological niches.

27 May 2014

Researchers discover signaling pathway in cancer cells that invades nearby tissues

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

26 May 2014

Eliminating scar tissue, inflammation may make tumors more deadly, find researchers

New research represents a significant change in the understanding of how pancreatic cancer grows - and how it might be defeated.

23 May 2014

Supermodel mouse reveals critical role played by unknown gene that regulates metabolism

A lean "Supermodel" mouse type has revealed the potentially critical role played by a largely unknown gene that regulates metabolism, findings that could provide new insight into diseases ranging from diabetes to obesity, a new study by UT-Southwestern Medical Center researchers suggests.

21 May 2014

Signaling Pathway News and Research

Biologists identify signaling pathway that switches on calorie-burning process in brown fat cells

Signaling pathway key player in formation of front-most portion of developing vertebrate embryos

TAZ represents a novel therapeutic target in NSCLC

New role for cholesterol in activation of cellular signaling pathway that linked to cancer

Scientists develop RNA that binds cGMP

New knowledge may expand treatments for patients with lung cancer

TCGA finds novel mutations in key cancer-causing pathway in lung adenocarcinoma

Small antioxidant molecules suppress colon cancer associated with colitis

Single dose restores normal cellular signaling in mouse model of autism

Signaling pathway may help explain why body clocks of people with bipolar disease

Researchers uncover several gene networks with potentially important roles in autism

Gene networks may offer attractive targets for developing new autism drugs

Regeneration of a chronically diseased liver may be possible, say Harvard researchers

New study of how biodiversity arises

Researchers discover signaling pathway in cancer cells that invades nearby tissues

Eliminating scar tissue, inflammation may make tumors more deadly, find researchers

Supermodel mouse reveals critical role played by unknown gene that regulates metabolism

Suppressing hyperactivity of calcium channels alleviates familial Alzheimer's disease

SGK1 enzyme, asthma and cancer therapies: an interview with Dr. Jonathan D. Powell, Johns Hopkins Kimmel Cancer Center

Neuron-to-neuron communication plays essential role in development of synapses

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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