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UCSF stem cell study suggests novel strategy for heart attack

A UCSF stem cell study conducted in mice suggests a novel strategy for treating damaged cardiac tissue in patients following a heart attack. The approach potentially could improve cardiac function, minimize scar size, lead to the development of new blood vessels - and avoid the risk of tissue rejection.

16 Feb 2012

Deep brain stimulation can also affect respiratory function

Deep brain stimulation (DBS) has become a common treatment for patients with chronic pain or movement disorders. Now a unique set of experiments shows that electrical stimulation in some of the same brain areas can also affect respiratory function, according to a study in the February issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

16 Feb 2012

Researchers discover a connection of peroxisomal protein import and receptor export

The group of Prof. Dr. Ralf Erdmann at the Ruhr-Universit-t Bochum discovered a connection of peroxisomal protein import and receptor export. In the Journal of Biological Chemistry, they disclosed that enzymes only get imported into certain cell organelles (peroxisomes) upon coupling of their import to the recycling of their transport protein.

13 Feb 2012

UC Riverside uncovers new insight into colon cancer

An international research team led by cell biologists at the University of California, Riverside has uncovered a new insight into colon cancer, the third leading cause of cancer-related deaths in the United States. The research provides potential new avenues for diagnosing and treating the disease.

10 Feb 2012

Scientists search gene alterations in three-parent kids

Researchers from Australia want to find out if using the DNA of three parents will prevent children inheriting life-threatening diseases. They add that if the technique proves successful in preventing the transfer of mitochondrial DNA mutations from mothers to babies, then laws on the use of embryos will need to be changed to allow the procedure.

6 Feb 2012

Scientists discover extremely long-lived proteins in aging rats

One of the big mysteries in biology is why cells age. Now scientists at the Salk Institute for Biological Studies report that they have discovered a weakness in a component of brain cells that may explain how the aging process occurs in the brain.

4 Feb 2012

Scientists identify molecular switch that controls ATF2's dual functions

The National Cancer Institute (NCI) estimates that as many as one in 51 men and women will be diagnosed with melanoma-the deadliest form of skin cancer-at some point during their lifetimes. A research team led by Ze'ev Ronai, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) is working to unravel the molecular mechanisms underlying the development and progression of this disease in hopes of improving prevention and treatment strategies

3 Feb 2012

Scientists discover new mechanisms by which RNA drugs can control gene activity

Small RNA-based nucleic acid drugs represent a promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes, and researchers have discovered new mechanisms by which RNA drugs can control gene activity.

3 Feb 2012

Over-exposure to noise can cause more lasting changes to auditory circuitry

We all know that it can take a little while for our hearing to bounce back after listening to our iPods too loud or attending a raucous concert. But new research at the University of Michigan Health System suggests over-exposure to noise can actually cause more lasting changes to our auditory circuitry - changes that may lead to tinnitus, commonly known as ringing in the ears.

2 Feb 2012

Cancer Genomics now available online

Genome Research publishes online and in print today a special issue entitled, "Cancer Genomics," highlighting insights gained form cutting-edge genomic and epigenomic analyses of cancer.

2 Feb 2012

Nanosize titanates may inhibit growth of oral cancer and bacterial cell lines

Sometimes bigger isn't better. Researchers at the U.S. Department of Energy's Savannah River National Laboratory have successfully shown that they can replace useful little particles of monosodium titanate (MST) with even tinier nano-sized particles, making them even more useful for a variety of applications.

1 Feb 2012

First evidence links cancer to mutations in genes involved in DNA organization

St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project provides first evidence linking cancer to mutations in genes involved in DNA organization

30 Jan 2012

SENP1 prevents STAT5 from becoming trapped in nucleus

When SUMO grips STAT5, a protein that activates genes, it blocks the healthy embryonic development of immune B cells and T cells unless its nemesis breaks the hold, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports today in Molecular Cell.

30 Jan 2012

Researchers study new strategies to treat patients with influenza

Influenza virus can rapidly evolve from one form to another, complicating the effectiveness of vaccines and anti-viral drugs used to treat it. By first understanding the complex host cell pathways that the flu uses for replication, University of Georgia researchers are finding new strategies for therapies and vaccines, according to a study published in the January issue of the Journal of the Federation of American Societies for Experimental Biology.

30 Jan 2012

Rotational motion plays a critical role in ability of breast cells to form acini

In a study that holds major implications for breast cancer research as well as basic cell biology, scientists with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory have discovered a rotational motion that plays a critical role in the ability of breast cells to form the spherical structures in the mammary gland known as acini.

27 Jan 2012

Scientists connect two signature characteristics of pancreatic cancer

Scientists have connected two signature characteristics of pancreatic cancer, identifying a self-perpetuating "vicious cycle" of molecular activity and a new potential target for drugs to treat one of the most lehal forms of cancer.

27 Jan 2012

Moral imagination helps dirty workers to overcome profession-related stigmas

There are some jobs ("dirty work", in Anglo-Saxon terminology) that, because of their characteristics, produce a certain amount of social rejection towards the people who perform them, due to the fact that they are subjected to moral conflicts and ethical decisions related to performing those duties.

24 Jan 2012

Methylation also plays a significant role outside the nucleus

The same mechanism that stabilises the DNA in the cell nucleus is also important for the structure and function of vertebrate muscle cells. This has been established by RUB-researchers led by Prof. Dr. Wolfgang Linke (Institute of Physiology) in cooperation with American and German colleagues.

24 Jan 2012

RPB awards $220,000 to SUNY Downstate for eye research

Capping SUNY Downstate Medical Center's growth into a major center for eye research, Research to Prevent Blindness (RPB) has awarded SUNY Downstate a four-year challenge grant of $220,000 to spur the development of advanced research into the causes, treatment, and prevention of blinding diseases. Douglas R. Lazzaro, MD, professor and chair of ophthalmology, is the principal investigator.

24 Jan 2012

Small-group dynamics can alter expression of IQ in some susceptible people

In the classic film "12 Angry Men," Henry Fonda's character sways a jury with his quiet, persistent intelligence. But would he have succeeded if he had allowed himself to fall sway to the social dynamics of that jury? Research led by scientists at the Virginia Tech Carilion Research Institute found that small-group dynamics -- such as jury deliberations, collective bargaining sessions, and cocktail parties -- can alter the expression of IQ in some susceptible people.

23 Jan 2012