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Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Clinical trial underway for novel human milk-based microbiome therapy

In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient in a Phase 2a clinical trial evaluating a novel therapy for blood cancer patients undergoing allogeneic hematopoietic stem cell transplantation.

10 Nov 2023

How do sex hormones and birth control affect brain fear circuits?

Researchers explores how oral contraceptive pill use interacts with the current hormonal status to affect the fear circuit structure within the brain.

9 Nov 2023

Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Fluoride and sealants win against youth dental caries, a robust review informs US health policy

In a comprehensive review for the JAMA Network, researchers find that preventive oral health interventions like fluoride treatments and sealants are effective in combating dental caries in youth, offering actionable insights for the US Preventive Services Task Force and healthcare providers.

8 Nov 2023

Human tissue model reveals diversity of bacterial strategies for urinary tract infections

The research, published today in Science Advances, is the first to use a sophisticated human tissue model to explore the interaction between host and pathogen for six common species that cause urinary tract infections.

8 Nov 2023

Which pharmacotherapies are associated with improved outcomes for people with alcohol use disorder?

Researchers assessed the efficacy and compared the relative effectiveness of various pharmacological treatments for alcohol use disorder.

8 Nov 2023

US to cover HIV prevention drugs for older Americans to stem spread of the virus

A proposed federal policy aims to protect older Americans from contracting HIV by offering free preventive medication, the latest effort to catch up to much of Europe and Africa in stemming the spread of the virus.

8 Nov 2023

Salivary gland abnormalities in primary Sjögren's become more severe over time, study shows

New research at ACR Convergence 2023, the American College of Rheumatology's (ACR) annual meeting, shows that ultrasound-detected salivary gland abnormalities in primary Sjögren's become more severe over time and that the slow-to-progress disease likely starts long before it is first detected.

7 Nov 2023

New method could enhance the ability to detect and predict anaphylaxis during oral food challenges

Food allergies can quickly turn a casual meal into a life-threatening situation.

7 Nov 2023

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) that affect the gastrointestinal tract.

7 Nov 2023

Probiotics paired with metformin could be a game-changer in type 2 diabetes control

Probiotic supplementation shows promise in managing type 2 diabetes by improving glycemic control, particularly when combined with metformin, although results vary based on probiotic composition and regimen.

6 Nov 2023

Practical tips for making healthcare systems more sustainable

Cutting nitrous oxide waste in hospitals, switching to reusable vaginal speculums for cervical screening, and prescribing tablets over intravenous drugs are just some of the tangible actions doctors can take to reduce the carbon footprint of healthcare.

6 Nov 2023

Study shows the effects of oral contraceptive use on women’s brains

More than 150 million women worldwide use oral contraceptives. Combined OCs (COCs), made up of synthetic hormones, are the most common type. Sex hormones are known to modulate the brain network involved in fear processes.

6 Nov 2023

Study probes the hidden impact of low-cal sweeteners on gut health

The research scrutinizes the impact of low- and non-calorie sweeteners on gut microbiota, suggesting potential links to glucose tolerance and insulin resistance, with varying results across studies indicating a need for more comprehensive research.

5 Nov 2023

Kicking the habit: Oral microbiota bounces back five years after quitting smoking

Study finds that smoking reshapes the oral microbiome by favoring anaerobic bacteria, potentially contributing to health risks, yet the effects may reverse if smoking is ceased for over five years, restoring a microbiota similar to that of non-smokers.

5 Nov 2023

Dental opioid prescribing declines in the U.S., but pandemic slows progressNovember 3, 2023

Americans who have a tooth pulled or another painful dental procedure in the United States today are far less likely to get opioid painkillers than they were just a few years ago, a University of Michigan study shows.

3 Nov 2023

New prediction model estimates risk of opioid relapse early in treatment

A newly developed prediction model may be able to calculate the risk of opioid relapse among individuals in the early stages of medication treatment - as early as three weeks into therapy.

3 Nov 2023

Modifying the gut microbiota can ameliorate hypertensive kidney damage and inflammation

New research in rodents indicates that altering gut microbes may affect the development of organ damage associated with hypertension.

2 Nov 2023

Balancing act: Navigating elimination diets in allergic kids without compromising nutrition

Recent research underscores the importance of careful management of elimination diets in children with food allergies, ensuring nutritional balance and support for growth. The study advocates for a multidisciplinary approach to help children avoid allergens without compromising their overall health and development.

2 Nov 2023

Oral News and Research

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Clinical trial underway for novel human milk-based microbiome therapy

How do sex hormones and birth control affect brain fear circuits?

Charting the future of IBD treatment: From immune modulators to microRNA therapies

Fluoride and sealants win against youth dental caries, a robust review informs US health policy

Human tissue model reveals diversity of bacterial strategies for urinary tract infections

Which pharmacotherapies are associated with improved outcomes for people with alcohol use disorder?

US to cover HIV prevention drugs for older Americans to stem spread of the virus

Salivary gland abnormalities in primary Sjögren's become more severe over time, study shows

New method could enhance the ability to detect and predict anaphylaxis during oral food challenges

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Probiotics paired with metformin could be a game-changer in type 2 diabetes control

Practical tips for making healthcare systems more sustainable

Study shows the effects of oral contraceptive use on women’s brains

Study probes the hidden impact of low-cal sweeteners on gut health

Kicking the habit: Oral microbiota bounces back five years after quitting smoking

Dental opioid prescribing declines in the U.S., but pandemic slows progressNovember 3, 2023

New prediction model estimates risk of opioid relapse early in treatment

Modifying the gut microbiota can ameliorate hypertensive kidney damage and inflammation

Balancing act: Navigating elimination diets in allergic kids without compromising nutrition

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